ACTC1 and SYNE2

Number of citations of the paper that reports this interaction (PubMedID 12408964)
0

Data Source:
HPRD (in vivo)

		ACTC1	SYNE2
Description		actin alpha cardiac muscle 1	spectrin repeat containing nuclear envelope protein 2
Image
GO Annotations	Cellular Component	Extracellular Space Cytoplasm Cytosol Cytoskeleton Actin Filament Focal Adhesion Actin Cytoskeleton Membrane Sarcomere Lamellipodium Filopodium I Band Cell Body Synapse Extracellular Exosome Blood Microparticle Glutamatergic Synapse	Fibrillar Center Nucleus Nuclear Envelope Nuclear Outer Membrane Nucleoplasm Nucleolus Cytoplasm Mitochondrion Cytoskeleton Plasma Membrane Focal Adhesion Cilium Membrane Sarcoplasmic Reticulum Myofibril Z Disc Lamellipodium Membrane Filopodium Membrane Nuclear Membrane Nuclear Lumen Sarcoplasmic Reticulum Membrane Meiotic Nuclear Membrane Microtubule Tethering Complex Intermediate Filament Cytoskeleton Extracellular Exosome Anchoring Junction
	Molecular Function	Microfilament Motor Activity Nucleotide Binding Protein Binding ATP Binding Hydrolase Activity Myosin Binding	Actin Binding Protein Binding Cytoskeleton-nuclear Membrane Anchor Activity
	Biological Process	Actin Filament Organization Response To Xenobiotic Stimulus Positive Regulation Of Gene Expression Actin Filament-based Movement Skeletal Muscle Thin Filament Assembly Actomyosin Structure Organization Actin-myosin Filament Sliding Negative Regulation Of Apoptotic Process Response To Ethanol Cardiac Myofibril Assembly Cardiac Muscle Tissue Morphogenesis Heart Contraction Cardiac Muscle Contraction Cytoplasmic Actin-based Contraction Involved In Cell Motility Mesenchyme Migration	Nuclear Migration Nucleokinesis Involved In Cell Motility In Cerebral Cortex Radial Glia Guided Migration Positive Regulation Of Cell Migration Nuclear Migration Along Microfilament Centrosome Localization Regulation Of Cilium Assembly
Pathways		Striated Muscle Contraction RHOA GTPase cycle RHOB GTPase cycle Regulation of CDH1 Function Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)	Meiotic synapsis
Drugs
Diseases		Dilated cardiomyopathy (DCM) Hypertrophic cardiomyopathy (HCM) Atrial septal defect	Emery-Dreifuss muscular dystrophy
GWAS		Axial length ( 24144296) Refractive error ( 20835239 32231278)	Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Atrial fibrillation ( 22544366 28416818 29892015 30061737) Blond vs. brown/black hair color ( 30531825) Cutaneous malignant melanoma ( 32341527) Cutaneous melanoma or hair colour ( 32341527) Depression ( 29700475) HDL cholesterol levels ( 32109663) Metabolite levels ( 23823483) Nevus count or cutaneous melanoma ( 30429480 32341527) PR interval ( 32439900) Psoriasis ( 25854761) Pulmonary function decline ( 22424883) Serum metabolite concentrations in chronic kidney disease ( 29545352) Serum metabolite levels ( 33031748) Serum metabolite ratios in chronic kidney disease ( 29545352) Sphingomyelin levels ( 31551469) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		43 interacting genes: ABLIM3 ABRA ACTB ACTN4 ACTR2 AFAP1 ANG ASH2L BCL11A C1QTNF9 CAPN1 CFL1 DMD DMTN DYNLL1 EZR FBXO7 FSCN1 GAPDH GC HSPB1 HSPB2 KAT14 KLHL17 KLHL2 KPTN LASP1 LINC00624 MIB2 MPC1 MYLK OGT PLEC PRKCE SCIN SLC4A1 SYNE1 SYNE2 TNNI3K TWF1 UBC WAS WIPF1	12 interacting genes: ABI1 ACTC1 BRAP CALM1 CTNNB1 MAPK3 MAPK8IP2 MEOX2 MTNR1B PML RNF10 SASH1
Entrez ID		70	23224
HPRD ID		00015	09763
Ensembl ID		ENSG00000159251	ENSG00000054654
Uniprot IDs		B3KPP5 P68032	Q8WXH0
PDB IDs		8GSU 8GSW 8GT1 8GT2 8GT3 8GT4 8GT5 8ZB7 8ZI9 8ZJ1 9B3Q 9B3R	4DXS 4FI9 6XF1
Enriched GO Terms of Interacting Partners?		Actin Binding Actin Cytoskeleton Actin Filament Binding Cytoskeleton Actin Filament-based Process Actin Filament Organization Cytoplasm Focal Adhesion Regulation Of Lamellipodium Assembly Actin Filament Supramolecular Fiber Organization Regulation Of Lamellipodium Organization Actin Polymerization Or Depolymerization Actin Cytoskeleton Organization Myofibril Cell Projection Assembly Lamellipodium Regulation Of Plasma Membrane Bounded Cell Projection Organization Cytoskeleton Organization Regulation Of Cell Projection Organization Cortical Cytoskeleton Z Disc Postsynaptic Actin Cytoskeleton Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Cell Projection Assembly Filopodium Regulation Of Actin Cytoskeleton Organization Stress Fiber Plasma Membrane Bounded Cell Projection Assembly Negative Regulation Of Actin Filament Depolymerization Regulation Of Cellular Component Size Regulation Of Actin Filament-based Process Cell Projection Regulation Of Actin Filament Depolymerization Regulation Of Protein-containing Complex Assembly Brush Border Regulation Of Actin Filament Polymerization Actin Filament-based Movement Extracellular Exosome Cytosol Negative Regulation Of Protein-containing Complex Assembly Positive Regulation Of Lamellipodium Assembly Negative Regulation Of Protein-containing Complex Disassembly Negative Regulation Of Cytoskeleton Organization Negative Regulation Of Supramolecular Fiber Organization Regulation Of Cytoskeleton Organization Establishment Or Maintenance Of Cell Polarity Regulation Of Actin Filament Organization Cell Projection Organization	Trachea Formation Positive Regulation Of Cell Communication Intracellular Signaling Cassette Intracellular Signal Transduction MAPK Cascade Positive Regulation Of Telomere Maintenance Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Nuclear Receptor-mediated Signaling Pathway Animal Organ Formation Regulation Of Nervous System Process Nuclear Steroid Receptor Activity Positive Regulation Of Signal Transduction Protein Modification By Small Protein Conjugation Positive Regulation Of Intracellular Signal Transduction Hormone-mediated Signaling Pathway Regulation Of Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Signaling Regulation Of Stress-activated MAPK Cascade Anatomical Structure Formation Involved In Morphogenesis Lamellipodium Protein Kinase Binding Post-translational Protein Modification Positive Regulation Of MAPK Cascade Regulation Of Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Metabolic Process Anatomical Structure Morphogenesis Regulation Of Cell Communication Regulation Of Calcium Ion Transport Regulation Of Signaling Regulation Of Telomere Maintenance Via Telomerase Thymus Development Glial Cell Fate Determination SMAD Binding Negative Regulation Of Gliogenesis Phosphatase Binding Regulation Of Myelination Canonical Wnt Signaling Pathway Involved In Mesenchymal Stem Cell Differentiation Regulation Of Telomere Maintenance Via Telomere Lengthening Limb Development Nuclear Receptor Activity Intracellular Receptor Signaling Pathway Negative Regulation Of Translation In Response To Oxidative Stress Dendrite Morphogenesis Sarcomere Glutamatergic Synapse Regulation Of System Process
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