ACTC1 and SYNE2

Number of citations of the paper that reports this interaction (PMID 12118075)
75

Data Source:
HPRD (in vivo)

		ACTC1	SYNE2
Gene Name		actin, alpha, cardiac muscle 1	spectrin repeat containing, nuclear envelope 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Cytoplasm Cytosol Actin Filament Focal Adhesion Membrane Sarcomere I Band Actomyosin, Actin Portion Extracellular Vesicular Exosome Blood Microparticle	Nucleus Nuclear Envelope Nuclear Outer Membrane Nucleoplasm Cytoplasm Mitochondrion Focal Adhesion Integral Component Of Membrane Aggresome Sarcoplasmic Reticulum Z Disc Lamellipodium Membrane Filopodium Membrane Nuclear Membrane Nuclear Lumen Sarcoplasmic Reticulum Membrane LINC Complex Intermediate Filament Cytoskeleton Extracellular Vesicular Exosome
	Molecular Function	ATP Binding ATPase Activity Myosin Binding	Actin Binding Protein Binding Actin Filament Binding
	Biological Process	Apoptotic Process Metabolic Process Actin Filament-based Movement Muscle Filament Sliding Skeletal Muscle Thin Filament Assembly Actomyosin Structure Organization Actin-myosin Filament Sliding Response To Drug Negative Regulation Of Apoptotic Process Response To Ethanol Cardiac Myofibril Assembly Cardiac Muscle Tissue Morphogenesis Heart Contraction Cardiac Muscle Contraction	Nuclear Envelope Organization Nuclear Migration Establishment Or Maintenance Of Cell Polarity Fibroblast Migration Positive Regulation Of Cell Migration Nuclear Migration Along Microfilament Protein Localization To Nucleus Centrosome Localization Cytoskeletal Anchoring At Nuclear Membrane
Pathways		Striated Muscle Contraction	Meiotic synapsis
Drugs
Diseases
GWAS		Prostate cancer (gene x gene interaction) ( 22219177) Refractive error ( 20835239)	Atrial fibrillation ( 22544366) Pulmonary function decline ( 22424883)
Protein-Protein Interactions		35 interactors: ABLIM3 ABRA ACTB ACTN4 ACTR2 AFAP1 ANG BCL11A CAPN1 CFL1 DMD DMTN DYNLL1 EZR FSCN1 GAPDH GC HSPB1 KLHL17 KLHL2 KPTN LASP1 MIB2 MPC1 MYLK PLEC PRKCE SCIN SLC4A1 SYNE1 SYNE2 TNNI3K TWF1 WAS WIPF1	7 interactors: ACTC1 BRAP CALM1 MAPK3 MAPK8IP2 PML UBC
Entrez ID		70	23224
HPRD ID		00015	09763
Ensembl ID		ENSG00000159251	ENSG00000054654
Uniprot IDs		B3KPP5 P68032	Q6MZP0 Q8WXH0
PDB IDs			4DXS 4FI9
Enriched GO Terms of Interacting Partners?		Actin Filament-based Process Actin Cytoskeleton Organization Cytoskeleton Organization Actin Filament Organization Organelle Organization Movement Of Cell Or Subcellular Component Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Cellular Component Size Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Cellular Component Assembly Regulation Of Actin Filament-based Process Regulation Of Cellular Component Organization Actin Filament-based Movement Phagocytosis Blood Coagulation Fc Receptor Signaling Pathway Hemostasis Cellular Localization Actin Filament Bundle Assembly Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Organelle Organization Regulation Of Actin Filament Polymerization Actin Polymerization Or Depolymerization Regulation Of Protein Complex Assembly Platelet Activation Regulation Of Sodium Ion Transmembrane Transporter Activity Positive Regulation Of Cellular Component Movement Positive Regulation Of Cytoskeleton Organization Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Body Fluid Levels Regulation Of Sodium Ion Transmembrane Transport Wound Healing Positive Regulation Of Organelle Organization Vesicle-mediated Transport Endocytosis Nucleus Localization Negative Regulation Of Protein Complex Assembly Maintenance Of Protein Location In Cell Cell Activation Positive Regulation Of Wound Healing Maintenance Of Protein Location Immune Response-regulating Signaling Pathway Maintenance Of Location In Cell Response To Wounding Cell Projection Assembly	MAPK Cascade Signal Transduction By Phosphorylation Intracellular Signal Transduction Phosphorylation Positive Regulation Of Protein Modification Process Regulation Of Protein Phosphorylation Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Positive Regulation Of Protein Metabolic Process Regulation Of Phosphorylation Positive Regulation Of Transferase Activity Epidermal Growth Factor Receptor Signaling Pathway Defense Response Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Signal Transduction Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Phosphorus Metabolic Process Response To Fibroblast Growth Factor Phosphate-containing Compound Metabolic Process Positive Regulation Of Catalytic Activity Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Protein Phosphorylation Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Regulation Of Protein Kinase Activity Regulation Of Signaling Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Kinase Activity Innate Immune Response Fc Receptor Signaling Pathway Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Phosphorylation Positive Regulation Of Cell Cycle Response To Stress Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Cycle Apoptotic Process Toll-like Receptor 5 Signaling Pathway Programmed Cell Death Toll-like Receptor 10 Signaling Pathway DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Cell Death
Tagcloud ?		accompany ach3 ach4 cardiac cardiomyocytes cardiomyogenic cd29 commitment cscs elusive fate hdac hdac1 hdac2 hypothesize indicative loci mark modifications mscs myh6 myl2 noticed possess sca stronger tnni3 tnnt2 trichostatin	ago1 argonaute cassette chip clusters constitutive crossing deep elongation enhancer enhancers exon explaining implication inclusion intergenic intragenic intronic microrna overlapping paradoxically prominent rather rnai rnas seq sirnas splicing unexpectedly
Tagcloud (Difference) ?		accompany ach3 ach4 cardiac cardiomyocytes cardiomyogenic cd29 commitment cscs elusive fate hdac hdac1 hdac2 hypothesize indicative loci mark modifications mscs myh6 myl2 noticed possess sca stronger tnni3 tnnt2 trichostatin	ago1 argonaute cassette chip clusters constitutive crossing deep elongation enhancer enhancers exon explaining implication inclusion intergenic intragenic intronic microrna overlapping paradoxically prominent rather rnai rnas seq sirnas splicing unexpectedly
Tagcloud (Intersection) ?