CAPN1 and KNG1

Number of citations of the paper that reports this interaction (PMID 8253784)
3

Data Source:
HPRD (in vitro)

		CAPN1	KNG1
Gene Name		calpain 1, (mu/I) large subunit	kininogen 1
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Focal Adhesion Membrane Extracellular Vesicular Exosome	Extracellular Region Extracellular Space Plasma Membrane Platelet Alpha Granule Lumen Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Calcium-dependent Cysteine-type Endopeptidase Activity Calcium Ion Binding Protein Binding	Cysteine-type Endopeptidase Inhibitor Activity Receptor Binding Protein Binding Heparin Binding Zinc Ion Binding
	Biological Process	Proteolysis Positive Regulation Of Cell Proliferation Extracellular Matrix Disassembly Extracellular Matrix Organization Receptor Catabolic Process	Platelet Degranulation Smooth Muscle Contraction Inflammatory Response Negative Regulation Of Cell Adhesion Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Coagulation Blood Coagulation, Intrinsic Pathway Negative Regulation Of Endopeptidase Activity Platelet Activation Negative Regulation Of Blood Coagulation Positive Regulation Of Urine Volume Positive Regulation Of Renal Sodium Excretion Vasodilation Positive Regulation Of Apoptotic Process Negative Regulation Of Proteolysis
Pathways		Degradation of the extracellular matrix	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events Signaling by GPCR Class A/1 (Rhodopsin-like receptors) Platelet degranulation Metabolic disorders of biological oxidation enzymes GPCR ligand binding Formation of Fibrin Clot (Clotting Cascade) G alpha (q) signalling events GPCR downstream signaling Intrinsic Pathway Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK Response to elevated platelet cytosolic Ca2+ G alpha (i) signalling events Platelet activation, signaling and aggregation
Drugs
Diseases
GWAS			Activated partial thromboplastin time ( 22703881 20303064) Adiponectin levels ( 20876611)
Protein-Protein Interactions		50 interactors: ACTC1 ACTN2 AES ARF6 BCL2L1 BID CAPNS1 CASP14 CAST CBL CDK5R1 CLEC4G COL1A1 COL3A1 CREG1 CTSC DES ECHS1 F2R F2RL1 FANCA FANCG FHL2 GNG12 GPT GRIN2B HNRNPD IL1A INPP4A ITGB3 KNG1 LAMTOR1 MYBPC3 NDUFB7 NFE2L1 NFKBIA PRMT5 PSEN2 PTGDS RAD21 SH3BGR SLIT3 SPTAN1 SPTBN1 STAT3 SYNE1 TINAGL1 TP53 UFSP2 VIM	28 interactors: AGT APP CAPN1 CAPN2 CD93 CPN1 CTSG CTSK CTSL CTSS ECE1 ELANE F11 F2 FTL GP1BA HABP2 ITGB2 KLK1 KLKB1 KRT1 MEP1A PLAUR PLG PREP RXFP4 THBS1 VTN
Entrez ID		823	3827
HPRD ID		00253	01970
Ensembl ID		ENSG00000014216
Uniprot IDs		B2RDI5 B4DWH5 P07384	P01042
PDB IDs		1ZCM 2ARY	2WOK 4ASQ 4ASR 4ECB 4ECC
Enriched GO Terms of Interacting Partners?		Apoptotic Process Regulation Of Signal Transduction Programmed Cell Death Cell Death Death Movement Of Cell Or Subcellular Component Response To Stimulus Regulation Of Cell Death Regulation Of Signaling Muscle Filament Sliding Actin-myosin Filament Sliding Developmental Process Regulation Of Apoptotic Process Positive Regulation Of Signal Transduction Anatomical Structure Development Organ Development Response To Organic Substance Actin-mediated Cell Contraction Cell Differentiation Cell Development Protein Localization To Nucleus Protein Localization To Organelle System Development Enzyme Linked Receptor Protein Signaling Pathway Actin Filament-based Movement Multicellular Organismal Development Cell Surface Receptor Signaling Pathway Muscle Contraction Response To External Stimulus Anatomical Structure Morphogenesis Cellular Response To Stimulus Cell Activation Regulation Of Cellular Process Muscle System Process Axon Guidance Positive Regulation Of Transport Blood Coagulation Hemostasis Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Cellular Localization Rhythmic Process Platelet Activation Wound Healing Negative Regulation Of Cell Death Positive Regulation Of Cell Death Regulation Of Protein Localization Regulation Of Cellular Component Organization Protein Import Into Nucleus Response To Stress	Extracellular Matrix Organization Extracellular Structure Organization Negative Regulation Of Blood Coagulation Regulation Of Blood Coagulation Negative Regulation Of Coagulation Negative Regulation Of Wound Healing Regulation Of Wound Healing Proteolysis Extracellular Matrix Disassembly Fibrinolysis Regulation Of Fibrinolysis Protein Metabolic Process Regulation Of Body Fluid Levels Blood Coagulation Hemostasis Response To Stress Blood Coagulation, Intrinsic Pathway Positive Regulation Of Fibrinolysis Defense Response Wound Healing Response To Wounding Negative Regulation Of Fibrinolysis Immune System Process Protein Processing Positive Regulation Of Wound Healing Regulation Of Angiotensin Metabolic Process Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-angiotensin Cell Activation Regulation Of Inflammatory Response Collagen Catabolic Process Immune Response Protein Activation Cascade Collagen Metabolic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Platelet Activation Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Regulation Of Immune Response Positive Regulation Of Immune System Process Regulation Of Protein Processing Positive Regulation Of Immune Response Positive Regulation Of Blood Coagulation Toll-like Receptor Signaling Pathway Peptide Hormone Processing Regulation Of Immune System Process Bradykinin Catabolic Process Positive Regulation Of Coagulation Pattern Recognition Receptor Signaling Pathway Regulation Of Protein Metabolic Process
Tagcloud ?		5k3 alpl armitage beadchip bovinesnp50 bull catsper1 cohran dehygrogenase ethanolamine etnk1 friesian goldenhelix hibadh hydroxyisobutyrate kelch klhl1 loc785875 mc4r pdzrn4 prkcb rs110596818 rs110827324 rs110876480 rs29011704 sire srd5a2 svs7 trim36	ace ace2 agt agtr1 agtr2 allele arrhythmias bdkrb2 converting correction county descent european gender genotyped haplotype haplotypes king ren replicated rs1492099 rs710448 sca snp snps sudden variation variations washington
Tagcloud (Difference) ?		5k3 alpl armitage beadchip bovinesnp50 bull catsper1 cohran dehygrogenase ethanolamine etnk1 friesian goldenhelix hibadh hydroxyisobutyrate kelch klhl1 loc785875 mc4r pdzrn4 prkcb rs110596818 rs110827324 rs110876480 rs29011704 sire srd5a2 svs7 trim36	ace ace2 agt agtr1 agtr2 allele arrhythmias bdkrb2 converting correction county descent european gender genotyped haplotype haplotypes king ren replicated rs1492099 rs710448 sca snp snps sudden variation variations washington
Tagcloud (Intersection) ?