CAPN1 and UFSP2

Number of citations of the paper that reports this interaction (PubMedID 12358155)
0

Data Source:
HPRD (two hybrid)

		CAPN1	UFSP2
Description		calpain 1	UFM1 specific peptidase 2
Image			No pdb structure
GO Annotations	Cellular Component	Cornified Envelope Extracellular Region Cytoplasm Mitochondrion Lysosome Cytosol Plasma Membrane Focal Adhesion Membrane Extracellular Exosome Calpain Complex Ficolin-1-rich Granule Lumen	Nucleus Cytoplasm Endoplasmic Reticulum
	Molecular Function	Calcium-dependent Cysteine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Metal Ion Binding	Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity DeUFMylase Activity
	Biological Process	Proteolysis Positive Regulation Of Cell Population Proliferation Regulation Of Macroautophagy Receptor Catabolic Process Regulation Of Catalytic Activity Mammary Gland Involution Self Proteolysis NMDA Selective Glutamate Receptor Signaling Pathway	Proteolysis Blood Circulation Regulation Of Type II Interferon Production Ribosome Disassembly Regulation Of Intracellular Estrogen Receptor Signaling Pathway Rescue Of Stalled Ribosome Negative Regulation Of Proteolysis Involved In Protein Catabolic Process
Pathways		Degradation of the extracellular matrix Degradation of the extracellular matrix Neutrophil degranulation Formation of the cornified envelope Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Drugs		4-[[(2S)-2-[[(2S)-3-Carboxy-2-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]butyl-(diaminomethylidene)azanium N-[(benzyloxy)carbonyl]-L-leucyl-N-[(1S)-3-fluoro-1-(4-hydroxybenzyl)-2-oxopropyl]-L-leucinamide (2S)-4-METHYL-2-(3-PHENYLTHIOUREIDO)-N-((3S)-TETRAHYDRO-2-HYDROXY-3-FURANYL)PENTANAMIDE
Diseases
GWAS		Urate levels ( 31578528)
Interacting Genes		55 interacting genes: ACTC1 ACTN2 ARF6 ATG5 ATXN3 BCL2L1 BID CAPNS1 CASP14 CAST CBL CDK5R1 CLEC4G COL1A1 COL3A1 CREG1 CTSC DES ECHS1 F2R F2RL1 FANCA FANCG FHL2 GNG12 GPT GRIN2B HNRNPD IL1A INPP4A ITGB3 KCTD7 KNG1 LAMTOR1 MAPT MYBPC3 NDUFB7 NFE2L1 NFKBIA PRMT5 PSEN2 PTGDS RAD21 SH3BGR SLC22A1 SLIT3 SPTAN1 SPTBN1 STAT3 SYNE1 TINAGL1 TLE5 TP53 UFSP2 VIM	4 interacting genes: APOBEC1 CAPN1 LIG4 LMO1
Entrez ID		823	55325
HPRD ID		00253	07741
Ensembl ID		ENSG00000014216	ENSG00000109775
Uniprot IDs		B2RDI5 B4DWH5 P07384	B3KRI4 Q9NUQ7
PDB IDs		1ZCM 2ARY 7W7O 7X79 8GX3
Enriched GO Terms of Interacting Partners?		Organelle Organization Regulation Of Programmed Cell Death Response To Alcohol Regulation Of Organelle Organization Regulation Of Apoptotic Process Identical Protein Binding Positive Regulation Of Organelle Organization Regulation Of Multicellular Organismal Process Protease Binding Cytoplasm Regulation Of Signal Transduction Regulation Of Cellular Component Organization Developmental Process Regulation Of Cell Communication Regulation Of Signaling Cellular Response To Amino Acid Stimulus Positive Regulation Of Gene Expression Response To Lipid Positive Regulation Of Programmed Cell Death Negative Regulation Of MiRNA-mediated Gene Silencing Negative Regulation Of Post-transcriptional Gene Silencing By Regulatory NcRNA Negative Regulation Of Gene Expression Regulation Of Intracellular Signal Transduction Hepatocyte Apoptotic Process Cytosol Regulation Of Actin Filament Depolymerization Negative Regulation Of Apoptotic Process Cell Junction Maintenance Regulation Of Renin Secretion Into Blood Stream Regulation Of Autophagy Sarcomere Negative Regulation Of Programmed Cell Death Regulation Of Actin Filament-based Process Regulation Of Mitochondrial Membrane Permeability G-protein Beta-subunit Binding Regulation Of Protein Localization Response To Amino Acid Release Of Cytochrome C From Mitochondria Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Positive Regulation Of Signal Transduction Response To Fluoride Regulation Of Protein-containing Complex Disassembly Positive Regulation Of Apoptotic Process Cellular Component Maintenance Regulation Of Membrane Permeability Cysteine-type Peptidase Activity Positive Regulation Of Cellular Component Organization Regulation Of MiRNA-mediated Gene Silencing Negative Regulation Of Protein Localization	Response To Gamma Radiation Regulation Of Cell Population Proliferation MRNA Editing Complex Response To Ionizing Radiation Calpain Complex Establishment Of Integrated Proviral Latency DNA Ligase (ATP) Activity DNA Ligase IV Complex Pro-B Cell Differentiation T Cell Receptor V(D)J Recombination Establishment Of Viral Latency DNA Ligase Activity DN2 Thymocyte Differentiation Regulation Of T Cell Homeostatic Proliferation Chromosomal 5-methylcytosine DNA Demethylation Pathway Lipoprotein Biosynthetic Process Apolipoprotein B MRNA Editing Enzyme Complex NMDA Selective Glutamate Receptor Signaling Pathway Mammary Gland Involution Nucleotide-excision Repair, DNA Gap Filling DNA-dependent Protein Kinase-DNA Ligase 4 Complex Immunoglobulin V(D)J Recombination Nonhomologous End Joining Complex Metal Ion Binding Cytidine To Uridine Editing Cytidine Deaminase Activity Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Calcium-dependent Cysteine-type Endopeptidase Activity Self Proteolysis Double-strand Break Repair Via Classical Nonhomologous End Joining Single Strand Break Repair Lymphoid Progenitor Cell Differentiation AMP Binding Positive Regulation Of Gene Expression Via Chromosomal CpG Island Demethylation Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Negative Regulation Of Triglyceride Metabolic Process Low-density Lipoprotein Particle Clearance Cellular Response To Lithium Ion Lipoprotein Transport Base Conversion Or Substitution Editing Response To Radiation Response To Lithium Ion MRNA Modification Receptor Catabolic Process V(D)J Recombination Isotype Switching Somatic Recombination Of Immunoglobulin Genes Involved In Immune Response MRNA 3'-UTR AU-rich Region Binding Plasma Lipoprotein Particle Clearance Somatic Diversification Of Immunoglobulins Involved In Immune Response
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