ACTC1 and ANG

Number of citations of the paper that reports this interaction (PubMedID 8127865)
49

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		ACTC1	ANG
Description		actin alpha cardiac muscle 1	angiogenin
Image
GO Annotations	Cellular Component	Extracellular Space Cytoplasm Cytosol Cytoskeleton Actin Filament Focal Adhesion Actin Cytoskeleton Membrane Sarcomere Lamellipodium Filopodium I Band Cell Body Synapse Extracellular Exosome Blood Microparticle Glutamatergic Synapse	Extracellular Region Basement Membrane Extracellular Space Nucleus Chromosome Nucleolus Cytoplasm Cytosol Cytoplasmic Stress Granule Actin Cytoskeleton Endocytic Vesicle Growth Cone Angiogenin-PRI Complex Neuronal Cell Body
	Molecular Function	Microfilament Motor Activity Nucleotide Binding Protein Binding ATP Binding Hydrolase Activity Myosin Binding	Nucleic Acid Binding DNA Binding Actin Binding Nuclease Activity Endonuclease Activity RNA Endonuclease Activity RNA Nuclease Activity TRNA-specific Ribonuclease Activity Signaling Receptor Binding Copper Ion Binding Protein Binding Heparin Binding Hydrolase Activity RRNA Binding Peptide Binding Protein Homodimerization Activity Ribosome Binding Receptor Ligand Activity
	Biological Process	Actin Filament Organization Response To Xenobiotic Stimulus Positive Regulation Of Gene Expression Actin Filament-based Movement Skeletal Muscle Thin Filament Assembly Actomyosin Structure Organization Actin-myosin Filament Sliding Negative Regulation Of Apoptotic Process Response To Ethanol Cardiac Myofibril Assembly Cardiac Muscle Tissue Morphogenesis Heart Contraction Cardiac Muscle Contraction Cytoplasmic Actin-based Contraction Involved In Cell Motility Mesenchyme Migration	Angiogenesis Ovarian Follicle Development Oocyte Maturation Response To Hypoxia Response To Yeast Placenta Development Positive Regulation Of Endothelial Cell Proliferation Cytoplasmic Translation Receptor-mediated Endocytosis Cell Communication Signal Transduction RRNA Transcription Response To Hormone TRNA Decay Cell Migration Negative Regulation Of Translation Antibacterial Humoral Response Antifungal Humoral Response Signaling Actin Filament Polymerization Cell Differentiation Negative Regulation Of Translation In Response To Stress Cellular Response To Stress Stress Granule Assembly TRNA Stabilization Positive Regulation Of Phosphorylation Homeostatic Process Negative Regulation Of Apoptotic Process Innate Immune Response Negative Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Protein Secretion Defense Response To Gram-positive Bacterium Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Hematopoietic Stem Cell Proliferation
Pathways		Striated Muscle Contraction RHOA GTPase cycle RHOB GTPase cycle Regulation of CDH1 Function Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)	Adherens junctions interactions tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis
Drugs
Diseases		Dilated cardiomyopathy (DCM) Hypertrophic cardiomyopathy (HCM) Atrial septal defect	Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease
GWAS		Axial length ( 24144296) Refractive error ( 20835239 32231278)	Blood protein levels ( 30072576)
Interacting Genes		43 interacting genes: ABLIM3 ABRA ACTB ACTN4 ACTR2 AFAP1 ANG ASH2L BCL11A C1QTNF9 CAPN1 CFL1 DMD DMTN DYNLL1 EZR FBXO7 FSCN1 GAPDH GC HSPB1 HSPB2 KAT14 KLHL17 KLHL2 KPTN LASP1 LINC00624 MIB2 MPC1 MYLK OGT PLEC PRKCE SCIN SLC4A1 SYNE1 SYNE2 TNNI3K TWF1 UBC WAS WIPF1	8 interacting genes: ABCG8 ACTC1 ACTN2 ATP6AP1 CRIPTO PTEN RNH1 TNFSF8
Entrez ID		70	283
HPRD ID		00015	00105
Ensembl ID		ENSG00000159251	ENSG00000214274
Uniprot IDs		B3KPP5 P68032	P03950 W0UV28
PDB IDs		8GSU 8GSW 8GT1 8GT2 8GT3 8GT4 8GT5 8ZB7 8ZI9 8ZJ1 9B3Q 9B3R	1A4Y 1ANG 1AWZ 1B1E 1B1I 1B1J 1GV7 1H0D 1H52 1H53 1HBY 1K58 1K59 1K5A 1K5B 1UN3 1UN4 1UN5 2ANG 4AHD 4AHE 4AHF 4AHG 4AHH 4AHI 4AHJ 4AHK 4AHL 4AHM 4AHN 4AOH 4B36 5EOP 5EPZ 5EQO 5M9A 5M9C 5M9G 5M9J 5M9M 5M9P 5M9Q 5M9R 5M9S 5M9T 5M9V 7NPM 7PNJ 7PNP 7PNR 8AF0 9BDL 9BDN 9BDP
Enriched GO Terms of Interacting Partners?		Actin Binding Actin Cytoskeleton Actin Filament Binding Cytoskeleton Actin Filament-based Process Actin Filament Organization Cytoplasm Focal Adhesion Regulation Of Lamellipodium Assembly Actin Filament Supramolecular Fiber Organization Regulation Of Lamellipodium Organization Actin Polymerization Or Depolymerization Actin Cytoskeleton Organization Myofibril Cell Projection Assembly Lamellipodium Regulation Of Plasma Membrane Bounded Cell Projection Organization Cytoskeleton Organization Regulation Of Cell Projection Organization Cortical Cytoskeleton Z Disc Postsynaptic Actin Cytoskeleton Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Cell Projection Assembly Filopodium Regulation Of Actin Cytoskeleton Organization Stress Fiber Plasma Membrane Bounded Cell Projection Assembly Negative Regulation Of Actin Filament Depolymerization Regulation Of Cellular Component Size Regulation Of Actin Filament-based Process Cell Projection Regulation Of Actin Filament Depolymerization Regulation Of Protein-containing Complex Assembly Brush Border Regulation Of Actin Filament Polymerization Actin Filament-based Movement Extracellular Exosome Cytosol Negative Regulation Of Protein-containing Complex Assembly Positive Regulation Of Lamellipodium Assembly Negative Regulation Of Protein-containing Complex Disassembly Negative Regulation Of Cytoskeleton Organization Negative Regulation Of Supramolecular Fiber Organization Regulation Of Cytoskeleton Organization Establishment Or Maintenance Of Cell Polarity Regulation Of Actin Filament Organization Cell Projection Organization	Filopodium Sarcomere Synapse Actin Filament Titin Z Domain Binding Actin Filament Uncapping Plasma Membrane Apical Plasma Membrane Negative Regulation Of Synaptic Vesicle Clustering Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Angiogenin-PRI Complex Negative Regulation Of Intestinal Cholesterol Absorption Negative Regulation Of Intestinal Phytosterol Absorption Actomyosin Structure Organization Phospholipase C-activating Angiotensin-activated Signaling Pathway Central Nervous System Myelin Maintenance Rhythmic Synaptic Transmission Ribonuclease Inhibitor Activity Nodal Binding Negative Regulation Of Intestinal Absorption
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