CAPN1 and RAD21

Number of citations of the paper that reports this interaction (PMID 22145905)
3

Data Source:
BioGRID (affinity chromatography technology, enzymatic study)

		CAPN1	RAD21
Gene Name		calpain 1, (mu/I) large subunit	RAD21 homolog (S. pombe)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Focal Adhesion Membrane Extracellular Vesicular Exosome	Chromosome, Centromeric Region Chromatin Nucleoplasm Chromosome Cytosol Cohesin Complex Membrane Nuclear Meiotic Cohesin Complex
	Molecular Function	Calcium-dependent Cysteine-type Endopeptidase Activity Calcium Ion Binding Protein Binding	Protein Binding
	Biological Process	Proteolysis Positive Regulation Of Cell Proliferation Extracellular Matrix Disassembly Extracellular Matrix Organization Receptor Catabolic Process	Mitotic Cell Cycle Double-strand Break Repair DNA Recombination Regulation Of Transcription From RNA Polymerase II Promoter Apoptotic Process Chromosome Segregation Mitotic Nuclear Division Reciprocal Meiotic Recombination Cell Division Protein Localization To Chromatin
Pathways		Degradation of the extracellular matrix	Establishment of Sister Chromatid Cohesion Mitotic Prometaphase Mitotic Telophase/Cytokinesis Separation of Sister Chromatids Meiotic synapsis Cohesin Loading onto Chromatin Mitotic Anaphase S Phase M Phase Cell Cycle, Mitotic Resolution of Sister Chromatid Cohesion Mitotic Metaphase and Anaphase
Drugs
Diseases
GWAS
Protein-Protein Interactions		50 interactors: ACTC1 ACTN2 AES ARF6 BCL2L1 BID CAPNS1 CASP14 CAST CBL CDK5R1 CLEC4G COL1A1 COL3A1 CREG1 CTSC DES ECHS1 F2R F2RL1 FANCA FANCG FHL2 GNG12 GPT GRIN2B HNRNPD IL1A INPP4A ITGB3 KNG1 LAMTOR1 MYBPC3 NDUFB7 NFE2L1 NFKBIA PRMT5 PSEN2 PTGDS RAD21 SH3BGR SLIT3 SPTAN1 SPTBN1 STAT3 SYNE1 TINAGL1 TP53 UFSP2 VIM	28 interactors: CAPN1 CASP7 CFL1 COX2 CSTB DISC1 DYNLT1 FHL3 FLNB HNRNPH2 IL7R MSRB2 NUMA1 PPP1R15A PPP1R15B RPL10 RPL13 RPL35A SMARCA5 SMC1A SSU72 STAG1 STAG2 TMSB4X TNFRSF14 WAPAL WNT2B ZNF80
Entrez ID		823	5885
HPRD ID		00253	05924
Ensembl ID		ENSG00000014216	ENSG00000164754
Uniprot IDs		B2RDI5 B4DWH5 P07384	O60216
PDB IDs		1ZCM 2ARY
Enriched GO Terms of Interacting Partners?		Apoptotic Process Regulation Of Signal Transduction Programmed Cell Death Cell Death Death Movement Of Cell Or Subcellular Component Response To Stimulus Regulation Of Cell Death Regulation Of Signaling Muscle Filament Sliding Actin-myosin Filament Sliding Developmental Process Regulation Of Apoptotic Process Positive Regulation Of Signal Transduction Anatomical Structure Development Organ Development Response To Organic Substance Actin-mediated Cell Contraction Cell Differentiation Cell Development Protein Localization To Nucleus Protein Localization To Organelle System Development Enzyme Linked Receptor Protein Signaling Pathway Actin Filament-based Movement Multicellular Organismal Development Cell Surface Receptor Signaling Pathway Muscle Contraction Response To External Stimulus Anatomical Structure Morphogenesis Cellular Response To Stimulus Cell Activation Regulation Of Cellular Process Muscle System Process Axon Guidance Positive Regulation Of Transport Blood Coagulation Hemostasis Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Cellular Localization Rhythmic Process Platelet Activation Wound Healing Negative Regulation Of Cell Death Positive Regulation Of Cell Death Regulation Of Protein Localization Regulation Of Cellular Component Organization Protein Import Into Nucleus Response To Stress	Cell Division Mitotic Nuclear Division Cellular Protein Localization Viral Life Cycle Cytoskeleton Organization Mitotic Cell Cycle Process Negative Regulation Of DNA Endoreduplication Protein Localization To Endoplasmic Reticulum Cell Cycle Process Mitotic Cell Cycle Organelle Organization Protein Localization To Organelle Negative Regulation Of DNA Replication MRNA Metabolic Process Viral Process Protein Localization Cellular Localization Cellular Protein Complex Disassembly Regulation Of DNA Endoreduplication Protein Complex Disassembly Cell Cycle Negative Regulation Of Cell Cycle Viral Transcription Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay SRP-dependent Cotranslational Protein Targeting To Membrane Establishment Of Cell Polarity Negative Regulation Of DNA Metabolic Process Cotranslational Protein Targeting To Membrane Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum Regulation Of DNA Replication Sister Chromatid Cohesion Establishment Of Mitotic Spindle Orientation Actin Cytoskeleton Organization Translational Termination Establishment Of Mitotic Spindle Localization Establishment Of Spindle Orientation Establishment Of Protein Localization To Organelle Nuclear-transcribed MRNA Catabolic Process Actin Filament-based Process MRNA Catabolic Process Protein Targeting To Membrane Establishment Or Maintenance Of Cell Polarity Viral Entry Into Host Cell Translational Elongation Spindle Localization Regulation Of Metabolic Process Entry Into Host Cell RNA Catabolic Process Positive Regulation Of Translational Initiation In Response To Stress
Tagcloud ?		5k3 alpl armitage beadchip bovinesnp50 bull catsper1 cohran dehygrogenase ethanolamine etnk1 friesian goldenhelix hibadh hydroxyisobutyrate kelch klhl1 loc785875 mc4r pdzrn4 prkcb rs110596818 rs110827324 rs110876480 rs29011704 sire srd5a2 svs7 trim36	aberrations apart aspect ccnd1 clinicopathological copy covered encompassed endometrial erbb1 erbb2 erbb3 erbb4 esr1 frequent infiltration insufficient myometrial pakt1 pgr pik3ca prom1 rad27 runx1 scgb2a2 snai1 snai2 top2a younger
Tagcloud (Difference) ?		5k3 alpl armitage beadchip bovinesnp50 bull catsper1 cohran dehygrogenase ethanolamine etnk1 friesian goldenhelix hibadh hydroxyisobutyrate kelch klhl1 loc785875 mc4r pdzrn4 prkcb rs110596818 rs110827324 rs110876480 rs29011704 sire srd5a2 svs7 trim36	aberrations apart aspect ccnd1 clinicopathological copy covered encompassed endometrial erbb1 erbb2 erbb3 erbb4 esr1 frequent infiltration insufficient myometrial pakt1 pgr pik3ca prom1 rad27 runx1 scgb2a2 snai1 snai2 top2a younger
Tagcloud (Intersection) ?