CAPN1 and GNG12

Number of citations of the paper that reports this interaction (PMID 7493986)
8

Data Source:
HPRD (in vitro)

		CAPN1	GNG12
Gene Name		calpain 1, (mu/I) large subunit	guanine nucleotide binding protein (G protein), gamma 12
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Focal Adhesion Membrane Extracellular Vesicular Exosome	Heterotrimeric G-protein Complex Actin Filament Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Calcium-dependent Cysteine-type Endopeptidase Activity Calcium Ion Binding Protein Binding	Signal Transducer Activity PDZ Domain Binding Phosphate Ion Binding
	Biological Process	Proteolysis Positive Regulation Of Cell Proliferation Extracellular Matrix Disassembly Extracellular Matrix Organization Receptor Catabolic Process	Energy Reserve Metabolic Process Signal Transduction G-protein Coupled Receptor Signaling Pathway Synaptic Transmission Cerebral Cortex Development Response To Lipopolysaccharide Small Molecule Metabolic Process Cellular Response To Glucagon Stimulus
Pathways		Degradation of the extracellular matrix	Signaling by GPCR Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 1 Integration of energy metabolism G alpha (s) signalling events Activation of GABAB receptors Glucagon-type ligand receptors G beta:gamma signalling through PLC beta Signaling by Wnt Metabolic disorders of biological oxidation enzymes G protein gated Potassium channels Gastrin-CREB signalling pathway via PKC and MAPK Thromboxane signalling through TP receptor G alpha (z) signalling events G alpha (i) signalling events Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell ADP signalling through P2Y purinoceptor 12 Glucagon signaling in metabolic regulation Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits Inwardly rectifying K+ channels G-protein beta:gamma signalling Opioid Signalling Activation of Kainate Receptors upon glutamate binding Aquaporin-mediated transport Adrenaline,noradrenaline inhibits insulin secretion G alpha (q) signalling events GPCR downstream signaling Platelet homeostasis Platelet activation, signaling and aggregation Transmission across Chemical Synapses G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signal amplification Potassium Channels G beta:gamma signalling through PI3Kgamma G alpha (12/13) signalling events Class B/2 (Secretin family receptors) Prostacyclin signalling through prostacyclin receptor GABA B receptor activation GABA receptor activation Activation of G protein gated Potassium channels Vasopressin regulates renal water homeostasis via Aquaporins Regulation of insulin secretion GPCR ligand binding beta-catenin independent WNT signaling Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Ca2+ pathway G-protein activation
Drugs
Diseases
GWAS
Protein-Protein Interactions		50 interactors: ACTC1 ACTN2 AES ARF6 BCL2L1 BID CAPNS1 CASP14 CAST CBL CDK5R1 CLEC4G COL1A1 COL3A1 CREG1 CTSC DES ECHS1 F2R F2RL1 FANCA FANCG FHL2 GNG12 GPT GRIN2B HNRNPD IL1A INPP4A ITGB3 KNG1 LAMTOR1 MYBPC3 NDUFB7 NFE2L1 NFKBIA PRMT5 PSEN2 PTGDS RAD21 SH3BGR SLIT3 SPTAN1 SPTBN1 STAT3 SYNE1 TINAGL1 TP53 UFSP2 VIM	6 interactors: CAPN1 FHL2 GNB1 GNB2 GNB3 GNB4
Entrez ID		823	55970
HPRD ID		00253	13592
Ensembl ID		ENSG00000014216	ENSG00000172380
Uniprot IDs		B2RDI5 B4DWH5 P07384	Q9UBI6
PDB IDs		1ZCM 2ARY
Enriched GO Terms of Interacting Partners?		Apoptotic Process Regulation Of Signal Transduction Programmed Cell Death Cell Death Death Movement Of Cell Or Subcellular Component Response To Stimulus Regulation Of Cell Death Regulation Of Signaling Muscle Filament Sliding Actin-myosin Filament Sliding Developmental Process Regulation Of Apoptotic Process Positive Regulation Of Signal Transduction Anatomical Structure Development Organ Development Response To Organic Substance Actin-mediated Cell Contraction Cell Differentiation Cell Development Protein Localization To Nucleus Protein Localization To Organelle System Development Enzyme Linked Receptor Protein Signaling Pathway Actin Filament-based Movement Multicellular Organismal Development Cell Surface Receptor Signaling Pathway Muscle Contraction Response To External Stimulus Anatomical Structure Morphogenesis Cellular Response To Stimulus Cell Activation Regulation Of Cellular Process Muscle System Process Axon Guidance Positive Regulation Of Transport Blood Coagulation Hemostasis Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Cellular Localization Rhythmic Process Platelet Activation Wound Healing Negative Regulation Of Cell Death Positive Regulation Of Cell Death Regulation Of Protein Localization Regulation Of Cellular Component Organization Protein Import Into Nucleus Response To Stress	Cellular Response To Glucagon Stimulus Response To Glucagon Energy Reserve Metabolic Process Energy Derivation By Oxidation Of Organic Compounds Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Response To Hormone Generation Of Precursor Metabolites And Energy Response To Peptide Hormone Cellular Response To Organonitrogen Compound Response To Peptide Cellular Response To Hormone Stimulus Response To Organonitrogen Compound Small Molecule Metabolic Process Response To Organic Substance Oxidation-reduction Process Synaptic Transmission Cellular Response To Organic Substance Atrial Cardiac Muscle Cell Development Cell-cell Signaling Cardiac Muscle Cell Apoptotic Process Muscle Cell Apoptotic Process G-protein Coupled Receptor Signaling Pathway Signal Transduction Receptor Catabolic Process Cellular Response To Prostaglandin E Stimulus G-protein Coupled Acetylcholine Receptor Signaling Pathway Signaling Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Cell Communication Heart Trabecula Formation Ventricular Cardiac Muscle Cell Development Response To Prostaglandin E Cellular Response To Prostaglandin Stimulus Cellular Metabolic Process Regulation Of Rhodopsin Mediated Signaling Pathway Cellular Response To Catecholamine Stimulus Heart Trabecula Morphogenesis Ventricular Cardiac Muscle Cell Differentiation Cellular Response To Stimulus Rhodopsin Mediated Signaling Pathway Dopamine Receptor Signaling Pathway Substantia Nigra Development Androgen Receptor Signaling Pathway Cellular Response To Fatty Acid Trabecula Morphogenesis Neural Nucleus Development Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway
Tagcloud ?		5k3 alpl armitage beadchip bovinesnp50 bull catsper1 cohran dehygrogenase ethanolamine etnk1 friesian goldenhelix hibadh hydroxyisobutyrate kelch klhl1 loc785875 mc4r pdzrn4 prkcb rs110596818 rs110827324 rs110876480 rs29011704 sire srd5a2 svs7 trim36	adcy8 adcy9 br1 br2 consisted disturbance endometrial endometrium eventually fos g2 g3 gnb1 gng11 gng5 kinin kinins kras map2k2 mapk1 microarrays mitogenic oligonucleotide plcb4 prkacb prkar1a prkca reaching u133a
Tagcloud (Difference) ?		5k3 alpl armitage beadchip bovinesnp50 bull catsper1 cohran dehygrogenase ethanolamine etnk1 friesian goldenhelix hibadh hydroxyisobutyrate kelch klhl1 loc785875 mc4r pdzrn4 prkcb rs110596818 rs110827324 rs110876480 rs29011704 sire srd5a2 svs7 trim36	adcy8 adcy9 br1 br2 consisted disturbance endometrial endometrium eventually fos g2 g3 gnb1 gng11 gng5 kinin kinins kras map2k2 mapk1 microarrays mitogenic oligonucleotide plcb4 prkacb prkar1a prkca reaching u133a
Tagcloud (Intersection) ?