ACTC1 and ABRA

Number of citations of the paper that reports this interaction (PMID 11983702)
28

Data Source:
HPRD (in vivo)

		ACTC1	ABRA
Gene Name		actin, alpha, cardiac muscle 1	actin-binding Rho activating protein
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Cytoplasm Cytosol Actin Filament Focal Adhesion Membrane Sarcomere I Band Actomyosin, Actin Portion Extracellular Vesicular Exosome Blood Microparticle	Plasma Membrane Actin Cytoskeleton Sarcomere
	Molecular Function	ATP Binding ATPase Activity Myosin Binding	Transcription Coactivator Activity Actin Binding
	Biological Process	Apoptotic Process Metabolic Process Actin Filament-based Movement Muscle Filament Sliding Skeletal Muscle Thin Filament Assembly Actomyosin Structure Organization Actin-myosin Filament Sliding Response To Drug Negative Regulation Of Apoptotic Process Response To Ethanol Cardiac Myofibril Assembly Cardiac Muscle Tissue Morphogenesis Heart Contraction Cardiac Muscle Contraction	Protein Import Into Nucleus, Translocation Transcription, DNA-templated Positive Regulation Of Rho Protein Signal Transduction Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Pathways		Striated Muscle Contraction
Drugs
Diseases
GWAS		Prostate cancer (gene x gene interaction) ( 22219177) Refractive error ( 20835239)	Dental caries ( 23259602)
Protein-Protein Interactions		35 interactors: ABLIM3 ABRA ACTB ACTN4 ACTR2 AFAP1 ANG BCL11A CAPN1 CFL1 DMD DMTN DYNLL1 EZR FSCN1 GAPDH GC HSPB1 KLHL17 KLHL2 KPTN LASP1 MIB2 MPC1 MYLK PLEC PRKCE SCIN SLC4A1 SYNE1 SYNE2 TNNI3K TWF1 WAS WIPF1	4 interactors: ABLIM2 ACTA1 ACTB ACTC1
Entrez ID		70	137735
HPRD ID		00015	11608
Ensembl ID		ENSG00000159251	ENSG00000174429
Uniprot IDs		B3KPP5 P68032	Q8N0Z2
PDB IDs
Enriched GO Terms of Interacting Partners?		Actin Filament-based Process Actin Cytoskeleton Organization Cytoskeleton Organization Actin Filament Organization Organelle Organization Movement Of Cell Or Subcellular Component Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Cellular Component Size Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Cellular Component Assembly Regulation Of Actin Filament-based Process Regulation Of Cellular Component Organization Actin Filament-based Movement Phagocytosis Blood Coagulation Fc Receptor Signaling Pathway Hemostasis Cellular Localization Actin Filament Bundle Assembly Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Organelle Organization Regulation Of Actin Filament Polymerization Actin Polymerization Or Depolymerization Regulation Of Protein Complex Assembly Platelet Activation Regulation Of Sodium Ion Transmembrane Transporter Activity Positive Regulation Of Cellular Component Movement Positive Regulation Of Cytoskeleton Organization Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Body Fluid Levels Regulation Of Sodium Ion Transmembrane Transport Wound Healing Positive Regulation Of Organelle Organization Vesicle-mediated Transport Endocytosis Nucleus Localization Negative Regulation Of Protein Complex Assembly Maintenance Of Protein Location In Cell Cell Activation Positive Regulation Of Wound Healing Maintenance Of Protein Location Immune Response-regulating Signaling Pathway Maintenance Of Location In Cell Response To Wounding Cell Projection Assembly	Skeletal Muscle Thin Filament Assembly Skeletal Myofibril Assembly Muscle Filament Sliding Actin-myosin Filament Sliding Movement Of Cell Or Subcellular Component Actin-mediated Cell Contraction Cell Development Actin Filament-based Movement Myofibril Assembly Actin Cytoskeleton Organization Actin Filament-based Process Anatomical Structure Morphogenesis Actomyosin Structure Organization Striated Muscle Cell Development Muscle Cell Development Skeletal Muscle Fiber Adaptation Organelle Organization Cytoskeleton Organization Cell Differentiation Muscle Contraction Striated Muscle Cell Differentiation Muscle System Process Muscle Organ Development Actin Filament Organization System Development Striated Muscle Tissue Development Muscle Cell Differentiation Muscle Tissue Development Skeletal Muscle Adaptation Axon Guidance Multicellular Organismal Development Response To External Stimulus Anatomical Structure Development Cellular Component Assembly Organelle Assembly Muscle Structure Development Axonogenesis Developmental Process Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Cardiac Myofibril Assembly Skeletal Muscle Fiber Development Neuron Projection Morphogenesis Myotube Cell Development Response To Lithium Ion Cell Morphogenesis Involved In Differentiation Substantia Nigra Development Platelet Aggregation Neuron Projection Development
Tagcloud ?		accompany ach3 ach4 cardiac cardiomyocytes cardiomyogenic cd29 commitment cscs elusive fate hdac hdac1 hdac2 hypothesize indicative loci mark modifications mscs myh6 myl2 noticed possess sca stronger tnni3 tnnt2 trichostatin	angiitis angiopathy caa characteristically complicating cortico e4 flair gadolinium granulomatous headaches hyperintensities immunosuppressant immunosuppressants microbleeds obviating pcnsv recur responds scant steroids subcortical superimposed swi t2w transmural treatable vasculitis walls
Tagcloud (Difference) ?		accompany ach3 ach4 cardiac cardiomyocytes cardiomyogenic cd29 commitment cscs elusive fate hdac hdac1 hdac2 hypothesize indicative loci mark modifications mscs myh6 myl2 noticed possess sca stronger tnni3 tnnt2 trichostatin	angiitis angiopathy caa characteristically complicating cortico e4 flair gadolinium granulomatous headaches hyperintensities immunosuppressant immunosuppressants microbleeds obviating pcnsv recur responds scant steroids subcortical superimposed swi t2w transmural treatable vasculitis walls
Tagcloud (Intersection) ?