SIL1 and SMAD9

Number of citations of the paper that reports this interaction (PMID 15231748)
65

Data Source:
HPRD (two hybrid)

		SIL1	SMAD9
Gene Name		SIL1 nucleotide exchange factor	SMAD family member 9
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen	Intracellular Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Cytosol
	Molecular Function	Unfolded Protein Binding	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transforming Growth Factor Beta Receptor, Pathway-specific Cytoplasmic Mediator Activity Metal Ion Binding
	Biological Process	Protein Folding Intracellular Protein Transport	Ureteric Bud Development Response To Hypoxia Mullerian Duct Regression Transcription, DNA-templated Protein Phosphorylation Transforming Growth Factor Beta Receptor Signaling Pathway BMP Signaling Pathway Midbrain Development Hindbrain Development Intracellular Signal Transduction Positive Regulation Of Cell Differentiation Positive Regulation Of Transcription, DNA-templated Cartilage Development Bone Development Cellular Response To Organic Cyclic Compound
Pathways			Signaling by BMP
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: CCND3 HSPA5 SMAD9 UBQLN1	117 interactors: ABTB1 ACTB ACVR1 AFF1 AP2A1 ARHGAP9 ARID1B ARNT ASB2 ASH2L BAZ1A BTG2 C10orf2 CAMSAP1 CEP135 CHPF CLPB CPXM2 CSH1 CSH2 CTR9 CXXC5 CYP11A1 DIAPH3 DKK1 DNAJA3 DNAJC7 DST DSTN E4F1 EIF3C EIF3E EIF3F ERVV-1 EVC2 EXPH5 FLI1 FN1 FTL GRN HEY1 HEYL HUWE1 KDM1A KDM6A KIAA0226 KMT2D LEMD3 LMO4 LNPEP LRP5 MAN1A2 MAN1C1 MAN2B1 MBD1 MCM3AP METAP1 MGAT1 MTMR10 MTMR11 NAGK OTUB1 PABPC4 PAPPA PELP1 PHKA2 PIR PKP2 PLEC PNPLA2 PPARD PPP2R5E PRMT6 PSAP PSMD8 QARS RANBP9 RFX1 RMND5A RNF123 RRBP1 SECISBP2 SF3B1 SIL1 SMAD2 SMAD3 SMAD4 SMG1 SNRNP70 SPTBN1 STAG1 SVEP1 TBCD TERF1 TINAGL1 TMEM57 TOB1 TRIM29 TRIP12 TTC37 UBA6 UBE3A UBQLN1 UBQLN4 UNC45A VCPIP1 VPS8 XAB2 YWHAQ ZEB2 ZNF484 ZNF557 ZNF587 ZNF587B ZNF592 ZNF83 ZSCAN4
Entrez ID		64374	4093
HPRD ID		12150	04484
Ensembl ID		ENSG00000120725	ENSG00000120693
Uniprot IDs		Q9H173	O15198
PDB IDs
Enriched GO Terms of Interacting Partners?		Midbrain Development Regulation Of Protein Folding In Endoplasmic Reticulum Response To Endoplasmic Reticulum Stress Hindbrain Development Cerebellum Structural Organization Regulation Of Protein Ubiquitination Response To Hypoxia Mullerian Duct Regression ER Overload Response Maintenance Of Protein Localization In Endoplasmic Reticulum Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Regulation Of Protein Metabolic Process Anatomical Structure Regression Positive Regulation Of Transferase Activity Cellular Response To Antibiotic Anatomical Structure Arrangement Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Cellular Response To Toxic Substance Cellular Response To Glucose Starvation Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Cell Activation Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Cerebellar Purkinje Cell Layer Development Brain Development Cellular Response To Stimulus Substantia Nigra Development Regulation Of Kinase Activity ER-associated Ubiquitin-dependent Protein Catabolic Process Head Development Toxin Transport Cellular Response To Interleukin-4 Positive Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process Regulation Of Cellular Response To Oxidative Stress Response To Interleukin-4 Cerebellum Morphogenesis Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Neural Nucleus Development Hindbrain Morphogenesis Positive Regulation Of Nuclease Activity Central Nervous System Development Regulation Of Metabolic Process Response To Antibiotic Positive Regulation Of Metabolic Process Response To Stress Cerebellar Cortex Development	Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Gene Expression Cellular Metabolic Process Transcription, DNA-templated Biosynthetic Process RNA Metabolic Process RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Cellular Process Cellular Protein Metabolic Process Protein Metabolic Process Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Gastrulation Anterior/posterior Pattern Specification Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Developmental Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Multicellular Organismal Development Atrioventricular Valve Morphogenesis Endoderm Development Nitrogen Compound Metabolic Process Formation Of Primary Germ Layer Cell Differentiation Atrioventricular Valve Development Regulation Of Transcription From RNA Polymerase II Promoter Anatomical Structure Development Transcription From RNA Polymerase II Promoter Organ Development Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Metabolic Process Embryo Development Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process SMAD Protein Complex Assembly Posttranscriptional Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Pattern Specification Process
Tagcloud ?		3beta ad alteration bip brains chaperon chaperons egfp elevation endoplasmic er glycogen gsk hek293 hyperphosphorylation immunoglobulin longest meanwhile n2a overexpressed plasmid reticulum roles stably synthase tau tg2576 thapsigargin transfected
Tagcloud (Difference) ?		3beta ad alteration bip brains chaperon chaperons egfp elevation endoplasmic er glycogen gsk hek293 hyperphosphorylation immunoglobulin longest meanwhile n2a overexpressed plasmid reticulum roles stably synthase tau tg2576 thapsigargin transfected
Tagcloud (Intersection) ?