SIL1 and FEM1C

Number of citations of the paper that reports this interaction (PubMedID 33398170)
0

Data Source:
BioGRID (unspecified method, unspecified method, pull down, x-ray crystallography)

		SIL1	FEM1C
Description		SIL1 nucleotide exchange factor	fem-1 homolog C
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GO Annotations	Cellular Component	Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen	Ubiquitin Ligase Complex Nucleoplasm Cytoplasm Cytosol Cul2-RING Ubiquitin Ligase Complex
	Molecular Function	Adenyl-nucleotide Exchange Factor Activity Protein Binding Identical Protein Binding Unfolded Protein Binding	Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Protein Folding Cotranslational Protein Targeting To Membrane Intracellular Protein Transport Protein Transport	Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Via The C-end Degron Rule Pathway
Pathways			Neddylation
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Malaria ( 31844061)	Conotruncal heart defects (inherited effects) ( 28468790) Response to antidepressants (symptom improvement) ( 29160301)
Interacting Genes		6 interacting genes: CCND3 FEM1C HSPA5 SGTB SMAD9 UBQLN1	10 interacting genes: BCL2L11 CDK5R1 CEP63 LZTS2 MALT1 MCM8 OR51B2 PNMA1 RPGRIP1 SIL1
Entrez ID		64374	56929
HPRD ID		12150	16384
Ensembl ID		ENSG00000120725	ENSG00000145780
Uniprot IDs		A0A0S2Z6B4 Q9H173	Q96JP0
PDB IDs		6LBN 6LEY 8PQL 8Q7R	6LBG 6LBN 6LDP 6LE6 6LEN 6LEY 6LF0 6XKC 7JYA 8PQL 8Q7R
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Post-translational Protein Modification Positive Regulation Of Protein Ubiquitination Regulation Of Cellular Response To Stress Regulation Of Protein Ubiquitination Regulation Of Post-translational Protein Modification Regulation Of Protein Folding In Endoplasmic Reticulum Regulation Of MRNA Stability Involved In Cellular Response To UV Regulation Of EIF2 Alpha Phosphorylation By DsRNA Negative Regulation Of Store-operated Calcium Channel Activity Ghrelin Receptor Binding Cortisol Secretion Positive Regulation Of Gastric Mucosal Blood Circulation FMN Biosynthetic Process Positive Regulation Of NAD(P)H Oxidase Activity Riboflavin Kinase Activity Riboflavin Biosynthetic Process Cyclin D3-CDK6 Complex Cyclin D3-CDK4 Complex Cerebellum Structural Organization Regulation Of Endoribonuclease Activity Growth Hormone-releasing Hormone Activity Negative Regulation Of Circadian Sleep/wake Cycle, REM Sleep Positive Regulation Of Small Intestinal Transit Positive Regulation Of Growth Rate TRC Complex Flavin Adenine Dinucleotide Biosynthetic Process Protein-folding Chaperone Binding Positive Regulation Of Protein Modification Process Regulation Of Response To Endoplasmic Reticulum Stress ERAD Pathway Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Synapse Assembly Positive Regulation Of Small Intestine Smooth Muscle Contraction Positive Regulation Of Bone Development Positive Regulation Of Growth Hormone Receptor Signaling Pathway Positive Regulation Of Cell Cycle Phase Transition Unfolded Protein Binding Regulation Of ATF6-mediated Unfolded Protein Response Positive Regulation Of Eating Behavior Positive Regulation Of Cortisol Secretion Positive Regulation Of Response To Food Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Regulation Of Circadian Sleep/wake Cycle, REM Sleep Positive Regulation Of Appetite Regulation Of Gastric Motility Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Riboflavin Metabolic Process Proteasomal Protein Catabolic Process Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Regulation Of Ribonuclease Activity
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