SIL1 and CCND3

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		SIL1	CCND3
Gene Name		SIL1 nucleotide exchange factor	cyclin D3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Cytoplasm Membrane
	Molecular Function	Unfolded Protein Binding	Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding Protein Kinase Binding
	Biological Process	Protein Folding Intracellular Protein Transport	Positive Regulation Of Protein Phosphorylation Cell Cycle Signal Transduction T Cell Proliferation Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Cell Division
Pathways			Cyclin D associated events in G1 Transcriptional regulation of white adipocyte differentiation G1 Phase Mitotic G1-G1/S phases Cell Cycle, Mitotic
Drugs
Diseases
GWAS			Hematological parameters ( 19820697) Mean corpuscular hemoglobin ( 20139978 19862010) Mean corpuscular volume ( 23263863 20139978 19862010) Metabolite levels (5-HIAA/ MHPG Ratio) ( 23319000) Neutrophil count ( 21507922) Red blood cell count ( 20139978) Red blood cell traits ( 23222517)
Protein-Protein Interactions		4 interactors: CCND3 HSPA5 SMAD9 UBQLN1	38 interactors: AKAP8 APP AREG ATF5 ATP5C1 CASP2 CDK11B CDK14 CDK4 CDK6 CDKN1A CDKN1B CRABP2 DMTF1 DTNBP1 EFEMP2 EIF3K ETV1 FAS GC MAF1 MAPK4 MAPK6 MCM10 MYB NCOA2 NME1 NPDC1 PCNA POLD1 POLR3GL RARA RB1 RBL2 RUNX1 SIL1 TFIP11 VDR
Entrez ID		64374	896
HPRD ID		12150	00452
Ensembl ID		ENSG00000120725	ENSG00000112576
Uniprot IDs		Q9H173	P30281 Q5T8J1
PDB IDs			3G33
Enriched GO Terms of Interacting Partners?		Midbrain Development Regulation Of Protein Folding In Endoplasmic Reticulum Response To Endoplasmic Reticulum Stress Hindbrain Development Cerebellum Structural Organization Regulation Of Protein Ubiquitination Response To Hypoxia Mullerian Duct Regression ER Overload Response Maintenance Of Protein Localization In Endoplasmic Reticulum Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Regulation Of Protein Metabolic Process Anatomical Structure Regression Positive Regulation Of Transferase Activity Cellular Response To Antibiotic Anatomical Structure Arrangement Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Cellular Response To Toxic Substance Cellular Response To Glucose Starvation Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Cell Activation Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Cerebellar Purkinje Cell Layer Development Brain Development Cellular Response To Stimulus Substantia Nigra Development Regulation Of Kinase Activity ER-associated Ubiquitin-dependent Protein Catabolic Process Head Development Toxin Transport Cellular Response To Interleukin-4 Positive Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process Regulation Of Cellular Response To Oxidative Stress Response To Interleukin-4 Cerebellum Morphogenesis Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Neural Nucleus Development Hindbrain Morphogenesis Positive Regulation Of Nuclease Activity Central Nervous System Development Regulation Of Metabolic Process Response To Antibiotic Positive Regulation Of Metabolic Process Response To Stress Cerebellar Cortex Development	Mitotic Cell Cycle Cell Cycle G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Mitotic Cell Cycle Process Cell Cycle Process Cellular Metabolic Process Organ Development Regulation Of Cell Cycle Regulation Of Gene Expression Positive Regulation Of Cell Cycle Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process System Development Response To Steroid Hormone Positive Regulation Of Metabolic Process Multicellular Organismal Development Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Metabolic Process Positive Regulation Of Cell Cycle Process Anatomical Structure Development Regulation Of Cell Cycle Phase Transition Positive Regulation Of Gene Expression Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Cellular Process Response To Lipid Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Metabolic Process Regulation Of Myeloid Cell Differentiation Response To Stimulus Developmental Process Response To Hormone Positive Regulation Of Macromolecule Biosynthetic Process Response To Hyperoxia Cellular Response To Stimulus Intracellular Receptor Signaling Pathway Regulation Of Cell Cycle Arrest Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Process Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Kinase Activity Response To Abiotic Stimulus Regulation Of Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of Mitotic Cell Cycle
Tagcloud ?		3beta ad alteration bip brains chaperon chaperons egfp elevation endoplasmic er glycogen gsk hek293 hyperphosphorylation immunoglobulin longest meanwhile n2a overexpressed plasmid reticulum roles stably synthase tau tg2576 thapsigargin transfected	abi1 atlas bitbucket ctnnd1 doi driver drivers dx fbln2 figshare hindered http https identifies implies isoform ktsp m9 mitf myh11 org pparg prdm1 ralgds regulatorygenomicsupf signatures splicing switches transcript
Tagcloud (Difference) ?		3beta ad alteration bip brains chaperon chaperons egfp elevation endoplasmic er glycogen gsk hek293 hyperphosphorylation immunoglobulin longest meanwhile n2a overexpressed plasmid reticulum roles stably synthase tau tg2576 thapsigargin transfected	abi1 atlas bitbucket ctnnd1 doi driver drivers dx fbln2 figshare hindered http https identifies implies isoform ktsp m9 mitf myh11 org pparg prdm1 ralgds regulatorygenomicsupf signatures splicing switches transcript
Tagcloud (Intersection) ?