SIL1 and HSPA5

Number of citations of the paper that reports this interaction (PMID 12356756)
28

Data Source:
HPRD (in vitro, two hybrid)

		SIL1	HSPA5
Gene Name		SIL1 nucleotide exchange factor	heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen	Nucleus Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Smooth Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Plasma Membrane Focal Adhesion COP9 Signalosome Cell Surface Membrane Integral Component Of Endoplasmic Reticulum Membrane Midbody Endoplasmic Reticulum Chaperone Complex Melanosome Extracellular Vesicular Exosome
	Molecular Function	Unfolded Protein Binding	Glycoprotein Binding Calcium Ion Binding Protein Binding ATP Binding ATPase Activity Enzyme Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Binding Ribosome Binding Unfolded Protein Binding Chaperone Binding Misfolded Protein Binding
	Biological Process	Protein Folding Intracellular Protein Transport	Platelet Degranulation ER Overload Response Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Blood Coagulation Cerebellum Structural Organization Cerebellar Purkinje Cell Layer Development Substantia Nigra Development Platelet Activation Positive Regulation Of Cell Migration ER-associated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Protein Ubiquitination Maintenance Of Protein Localization In Endoplasmic Reticulum Cellular Response To Glucose Starvation Negative Regulation Of Apoptotic Process Cellular Protein Metabolic Process Regulation Of Protein Folding In Endoplasmic Reticulum Cellular Response To Antibiotic Cellular Response To Interleukin-4 Toxin Transport
Pathways			Platelet degranulation Antigen Presentation: Folding, assembly and peptide loading of class I MHC ATF6-alpha activates chaperone genes IRE1alpha activates chaperones Response to elevated platelet cytosolic Ca2+ Class I MHC mediated antigen processing & presentation Platelet activation, signaling and aggregation ATF6-alpha activates chaperones PERK regulates gene expression Unfolded Protein Response (UPR) Adaptive Immune System
Drugs			Antihemophilic Factor
Diseases
GWAS
Protein-Protein Interactions		4 interactors: CCND3 HSPA5 SMAD9 UBQLN1	53 interactors: A2M APC APOB BCAR1 CASP7 CPT1A DDX24 DNAJC1 DNAJC10 DPH1 DPYSL5 EIF2AK3 ERN1 ERP29 F8 FCHSD2 GRB2 GRIA1 HLA-C HSPBP1 HTR3A ID2 IGHM KRT14 KRT18 KRT8 LCT LDLR METTL21A MTNR1A MTNR1B NDRG1 PAWR PCSK7 PRNP PSME3 RPN1 SEC61A1 SH3BP4 SIL1 SREBF2 STMN1 SUMO4 TCERG1 TG TMEM132A TMEM62 TRA TSHR UBQLN4 VHL VWF YWHAB
Entrez ID		64374	3309
HPRD ID		12150	00682
Ensembl ID		ENSG00000120725	ENSG00000044574
Uniprot IDs		Q9H173	P11021
PDB IDs			3IUC 3LDL 3LDN 3LDO 3LDP
Enriched GO Terms of Interacting Partners?		Midbrain Development Regulation Of Protein Folding In Endoplasmic Reticulum Response To Endoplasmic Reticulum Stress Hindbrain Development Cerebellum Structural Organization Regulation Of Protein Ubiquitination Response To Hypoxia Mullerian Duct Regression ER Overload Response Maintenance Of Protein Localization In Endoplasmic Reticulum Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Regulation Of Protein Metabolic Process Anatomical Structure Regression Positive Regulation Of Transferase Activity Cellular Response To Antibiotic Anatomical Structure Arrangement Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Cellular Response To Toxic Substance Cellular Response To Glucose Starvation Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Cell Activation Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Cerebellar Purkinje Cell Layer Development Brain Development Cellular Response To Stimulus Substantia Nigra Development Regulation Of Kinase Activity ER-associated Ubiquitin-dependent Protein Catabolic Process Head Development Toxin Transport Cellular Response To Interleukin-4 Positive Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process Regulation Of Cellular Response To Oxidative Stress Response To Interleukin-4 Cerebellum Morphogenesis Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Neural Nucleus Development Hindbrain Morphogenesis Positive Regulation Of Nuclease Activity Central Nervous System Development Regulation Of Metabolic Process Response To Antibiotic Positive Regulation Of Metabolic Process Response To Stress Cerebellar Cortex Development	Response To Stimulus Cellular Response To Stimulus Apoptotic Signaling Pathway Response To Stress Blood Coagulation, Intrinsic Pathway Cell Activation Signal Transduction Apoptotic Process Positive Regulation Of Metabolic Process Programmed Cell Death Signaling Positive Regulation Of Cellular Metabolic Process Intrinsic Apoptotic Signaling Pathway Cell Death Death Cell Communication Platelet Activation Regulation Of Proteolysis Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Body Fluid Levels Negative Regulation Of Cellular Protein Metabolic Process Blood Coagulation Negative Regulation Of Cellular Metabolic Process Protein Oligomerization Hemostasis Response To External Stimulus Cellular Response To Organic Substance Protein Folding Regulation Of Lipid Metabolic Process Response To Organic Substance Response To Inorganic Substance Negative Regulation Of Protein Metabolic Process Platelet Degranulation Lipoprotein Catabolic Process Regulation Of Apoptotic Process Regulation Of Cholesterol Homeostasis Hepatocyte Apoptotic Process Protein Metabolic Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cholesterol Storage Negative Regulation Of T Cell Receptor Signaling Pathway Axonogenesis Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Viral Process Cellular Response To Stress Cell Development Anatomical Structure Morphogenesis
Tagcloud ?		3beta ad alteration bip brains chaperon chaperons egfp elevation endoplasmic er glycogen gsk hek293 hyperphosphorylation immunoglobulin longest meanwhile n2a overexpressed plasmid reticulum roles stably synthase tau tg2576 thapsigargin transfected	17q 22cm canine centromeric cfa9 correspond cosmid cryba1 distal dog grp78 hsa17 hsa17q hsa9q hsa9q34 lies linkage loci map mmu2 nf1 occupy painting places probable rxra syntenic telomeric thirds
Tagcloud (Difference) ?		3beta ad alteration bip brains chaperon chaperons egfp elevation endoplasmic er glycogen gsk hek293 hyperphosphorylation immunoglobulin longest meanwhile n2a overexpressed plasmid reticulum roles stably synthase tau tg2576 thapsigargin transfected	17q 22cm canine centromeric cfa9 correspond cosmid cryba1 distal dog grp78 hsa17 hsa17q hsa9q hsa9q34 lies linkage loci map mmu2 nf1 occupy painting places probable rxra syntenic telomeric thirds
Tagcloud (Intersection) ?