CTPS2 and SPG21

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
HPRD (two hybrid)

		CTPS2	SPG21
Gene Name		CTP synthase 2	spastic paraplegia 21 (autosomal recessive, Mast syndrome)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrion Cytosol	Nucleus Nucleoplasm Cytoplasm Cytosol Endosome Membrane Trans-Golgi Network Transport Vesicle
	Molecular Function	CTP Synthase Activity ATP Binding	Protein Binding CD4 Receptor Binding
	Biological Process	Pyrimidine Nucleotide Metabolic Process Glutamine Metabolic Process Nucleobase-containing Small Molecule Interconversion 'de Novo' CTP Biosynthetic Process Small Molecule Metabolic Process Nucleobase-containing Small Molecule Metabolic Process	Antigen Receptor-mediated Signaling Pathway
Pathways		Metabolism of nucleotides Synthesis and interconversion of nucleotide di- and triphosphates
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: CTBP2 FGFR1 RPL23A RPL37A SPG21	37 interactors: AGTRAP AKIRIN2 ARL6IP1 ATPAF2 CCDC102B CCDC33 CD4 CMTM5 CRYAA CTPS2 CUTC DTX2 DTX3L EFHC2 FAM114A1 GGA2 GSK3A IKZF3 INCA1 KRT15 MID2 MTMR9 PRPS1 RABAC1 REEP6 RTN4 S100B SPRED2 TCF12 TCF4 TFG TRAF1 TRAF2 TRIM23 TRIM54 TRIM9 ZNF263
Entrez ID		56474	51324
HPRD ID		02305	10492
Ensembl ID		ENSG00000047230	ENSG00000090487
Uniprot IDs		Q9NRF8	Q9NZD8
PDB IDs		2V4U 2VKT 3IHL
Enriched GO Terms of Interacting Partners?		Viral Life Cycle Viral Process Viral Transcription Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay SRP-dependent Cotranslational Protein Targeting To Membrane Cotranslational Protein Targeting To Membrane Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum Protein Localization To Endoplasmic Reticulum Translational Termination Nuclear-transcribed MRNA Catabolic Process Regulation Of Lateral Mesodermal Cell Fate Specification Fibroblast Growth Factor Receptor Signaling Pathway Involved In Orbitofrontal Cortex Development MRNA Catabolic Process Protein Targeting To Membrane RNA Biosynthetic Process Translational Elongation RNA Catabolic Process Ventricular Zone Neuroblast Division Cellular Protein Complex Disassembly Protein Complex Disassembly Orbitofrontal Cortex Development Establishment Of Protein Localization To Membrane Translational Initiation Positive Regulation Of Retinoic Acid Receptor Signaling Pathway Forebrain Ventricular Zone Progenitor Cell Division Positive Regulation Of MAPKKK Cascade By Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Chromatin Binding RNA Metabolic Process Outer Ear Morphogenesis Regulation Of Branching Involved In Salivary Gland Morphogenesis By Mesenchymal-epithelial Signaling Gene Expression Establishment Of Protein Localization To Organelle Protein Localization To Membrane Cellular Macromolecule Biosynthetic Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Macromolecule Biosynthetic Process Mesenchymal-epithelial Cell Signaling Forebrain Neuroblast Division Protein Targeting Regulation Of Branching Involved In Salivary Gland Morphogenesis Auditory Receptor Cell Development Lung-associated Mesenchyme Development Aromatic Compound Catabolic Process Regulation Of Cell Fate Specification White Fat Cell Differentiation Immune Response-regulating Signaling Pathway Protein Localization To Organelle MRNA Metabolic Process Paraxial Mesoderm Development	Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Apoptotic Process Protein Ubiquitination Regulation Of Cell Death Protein Modification By Small Protein Conjugation Negative Regulation Of Developmental Growth Innate Immune Response Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Striated Muscle Tissue Development Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Interleukin-2 Production Positive Regulation Of Cell Death Immune Response Negative Regulation Of Organ Growth Negative Regulation Of UDP-glucose Catabolic Process Induction By Virus Of Host Cell-cell Fusion Protein Palmitoleylation Regulation Of Intracellular Signal Transduction Negative Regulation Of Muscle Cell Differentiation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Striated Muscle Tissue Development Regulation Of Cellular Localization Negative Regulation Of Muscle Organ Development Regulation Of Signal Transduction Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Pyrimidine Nucleotide Biosynthetic Process Regulation Of Intracellular Transport Negative Regulation Of Cell Differentiation Regulation Of Protein Kinase Activity Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of SNARE Complex Assembly Catenin Import Into Nucleus Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Urate Biosynthetic Process 'de Novo' CTP Biosynthetic Process Glycogen Metabolic Process Regulation Of Kinase Activity Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Cell Differentiation Positive Regulation Of Protein Binding Regulation Of Skeletal Muscle Tissue Development Regulation Of Cellular Ketone Metabolic Process Gliogenesis Negative Regulation Of Growth Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process
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