CTPS2 and CTBP2

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		CTPS2	CTBP2
Gene Name		CTP synthase 2	C-terminal binding protein 2
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Gene Ontology Annotations	Cellular Component	Mitochondrion Cytosol	Nucleus Transcriptional Repressor Complex Cell Junction Synapse
	Molecular Function	CTP Synthase Activity ATP Binding	Chromatin Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Retinoic Acid Receptor Binding NAD Binding
	Biological Process	Pyrimidine Nucleotide Metabolic Process Glutamine Metabolic Process Nucleobase-containing Small Molecule Interconversion 'de Novo' CTP Biosynthetic Process Small Molecule Metabolic Process Nucleobase-containing Small Molecule Metabolic Process	Transcription, DNA-templated Negative Regulation Of Cell Proliferation Viral Genome Replication Positive Regulation Of Chromatin Binding Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Retinoic Acid Receptor Signaling Pathway White Fat Cell Differentiation Oxidation-reduction Process
Pathways		Metabolism of nucleotides Synthesis and interconversion of nucleotide di- and triphosphates	APC truncation mutants have impaired AXIN binding misspliced GSK3beta mutants stabilize beta-catenin T41 mutants of beta-catenin aren't phosphorylated phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex AXIN missense mutants destabilize the destruction complex TCF7L2 mutants don't bind CTBP truncated APC mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated Signaling by Wnt APC truncation mutants are not K63 polyubiquitinated repression of WNT target genes S37 mutants of beta-catenin aren't phosphorylated Degradation of beta-catenin by the destruction complex deletions in the AMER1 gene destabilize the destruction complex AMER1 mutants destabilize the destruction complex S33 mutants of beta-catenin aren't phosphorylated AXIN mutants destabilize the destruction complex, activating WNT signaling deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Signaling by WNT in cancer truncations of AMER1 destabilize the destruction complex
Drugs
Diseases
GWAS			Prostate cancer ( 18264096)
Protein-Protein Interactions		5 interactors: CTBP2 FGFR1 RPL23A RPL37A SPG21	67 interactors: ACTG1 AKTIP APP BAZ2B BCAS3 BCL3 C15orf39 CASP8AP2 CBX4 CCNH CCR5 CDKN2A CTBP1 CTPS2 DMRTB1 DVL2 EEF1D ELAC2 EP300 FHL3 FLI1 FOXP2 FUNDC1 HIC1 HIST3H3 HOXB5 IKZF1 IKZF2 KLF3 KLF8 LCOR MDM2 MECOM NOL4 NOL4L NRIP1 PLCB1 PNN PPP1R15A PROX1 PSMF1 RAI2 RBBP8 RIMBP3 RPL17 RPL7A RPS28 RPS29 RPS4X RUNX1 SOX13 SOX6 STUB1 STX11 TEAD3 TGIF1 TSHZ3 UBE2I XRCC6 ZBP1 ZBTB18 ZEB1 ZEB2 ZFPM1 ZFPM2 ZNF512B ZNF750
Entrez ID		56474	1488
HPRD ID		02305	04016
Ensembl ID		ENSG00000047230	ENSG00000175029
Uniprot IDs		Q9NRF8	P56545 Q5SQP8
PDB IDs		2V4U 2VKT 3IHL	2OME
Enriched GO Terms of Interacting Partners?		Viral Life Cycle Viral Process Viral Transcription Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay SRP-dependent Cotranslational Protein Targeting To Membrane Cotranslational Protein Targeting To Membrane Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum Protein Localization To Endoplasmic Reticulum Translational Termination Nuclear-transcribed MRNA Catabolic Process Regulation Of Lateral Mesodermal Cell Fate Specification Fibroblast Growth Factor Receptor Signaling Pathway Involved In Orbitofrontal Cortex Development MRNA Catabolic Process Protein Targeting To Membrane RNA Biosynthetic Process Translational Elongation RNA Catabolic Process Ventricular Zone Neuroblast Division Cellular Protein Complex Disassembly Protein Complex Disassembly Orbitofrontal Cortex Development Establishment Of Protein Localization To Membrane Translational Initiation Positive Regulation Of Retinoic Acid Receptor Signaling Pathway Forebrain Ventricular Zone Progenitor Cell Division Positive Regulation Of MAPKKK Cascade By Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Chromatin Binding RNA Metabolic Process Outer Ear Morphogenesis Regulation Of Branching Involved In Salivary Gland Morphogenesis By Mesenchymal-epithelial Signaling Gene Expression Establishment Of Protein Localization To Organelle Protein Localization To Membrane Cellular Macromolecule Biosynthetic Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Macromolecule Biosynthetic Process Mesenchymal-epithelial Cell Signaling Forebrain Neuroblast Division Protein Targeting Regulation Of Branching Involved In Salivary Gland Morphogenesis Auditory Receptor Cell Development Lung-associated Mesenchyme Development Aromatic Compound Catabolic Process Regulation Of Cell Fate Specification White Fat Cell Differentiation Immune Response-regulating Signaling Pathway Protein Localization To Organelle MRNA Metabolic Process Paraxial Mesoderm Development	RNA Biosynthetic Process Gene Expression RNA Metabolic Process Transcription, DNA-templated Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Cellular Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Transcription From RNA Polymerase II Promoter Viral Process Metabolic Process Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Embryo Development Regulation Of Cellular Process Positive Regulation Of Protein Metabolic Process Developmental Process Cellular Process Multicellular Organismal Development Muscle Structure Development Muscle Organ Development Organ Development Positive Regulation Of Cellular Protein Metabolic Process
Tagcloud ?			acetylates acetylation corepressor correlating ctbps deacetylases demethylase dimerization ex527 exerts hdac hypoxic influencing interacted kdm1 ligation lsd1 microenvironmental modifying nscs pla proliferating proximity sensors sirt1 transferase unaltered undifferentiated
Tagcloud (Difference) ?			acetylates acetylation corepressor correlating ctbps deacetylases demethylase dimerization ex527 exerts hdac hypoxic influencing interacted kdm1 ligation lsd1 microenvironmental modifying nscs pla proliferating proximity sensors sirt1 transferase unaltered undifferentiated
Tagcloud (Intersection) ?