CDK5RAP2 and FBXO25

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		CDK5RAP2	FBXO25
Description		CDK5 regulatory subunit associated protein 2	F-box protein 25
Image			No pdb structure
GO Annotations	Cellular Component	Pericentriolar Material Spindle Pole Gamma-tubulin Ring Complex Cytoplasm Golgi Apparatus Centrosome Microtubule Organizing Center Cytosol Cytoskeleton Microtubule Cell Junction Microtubule Plus-end Ciliary Basal Body Perinuclear Region Of Cytoplasm Extracellular Exosome Mitotic Spindle Pole	Ubiquitin Ligase Complex Nucleus Nucleolus Cytoplasm SCF Ubiquitin Ligase Complex
	Molecular Function	Transcription Cis-regulatory Region Binding Protein Binding Calmodulin Binding Microtubule Binding Tubulin Binding Protein Kinase Binding Gamma-tubulin Binding Protein-containing Complex Binding	Actin Binding Ubiquitin-protein Transferase Activity Protein Binding
	Biological Process	Establishment Of Mitotic Spindle Orientation Microtubule Cytoskeleton Organization Microtubule Bundle Formation Chromosome Segregation Centrosome Cycle Centriole Replication Brain Development Neurogenesis Microtubule Organizing Center Organization Positive Regulation Of Microtubule Polymerization Regulation Of Neuron Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of DNA-templated Transcription Negative Regulation Of Centriole Replication Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint	Protein Ubiquitination
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases		Primary microcephaly (MCPH)
GWAS		Asthma ( 27611488) Height ( 28552196) Photic sneeze reflex ( 27182965) Response to statin therapy ( 20339536) Rheumatoid arthritis ( 24782177)	Neonatal cytokine/chemokine levels (fetal genetic effect) ( 30134952) Nontraumatic osteonecrosis of the femoral head ( 32701715)
Interacting Genes		26 interacting genes: ABCA2 CDK5 CDK5R1 CLIP4 CRMP1 EEF1G ERG28 FBXO25 HAP1 KAT5 LRRK1 LUC7L2 MAGEH1 MAPRE1 NEFL PCBD1 PTN RBM48 REPS2 SENP2 STARD9 STK36 TBC1D4 TRIM37 TSNAX ZPR1	82 interacting genes: ANKRD13A APLF AXL BMX BRME1 CDK5RAP2 CDK9 CENPB CHLSN CUL1 CXXC4 DCX DDX42 DEPTOR DNAJB2 DNAJC8 DYRK3 DYRK4 EGFR EID3 EIF4E2 ELK1 EPN1 FKBP3 G3BP1 GRK2 GTF2B GTF2IRD2 HIP1 HMCES HP1BP3 IL21 ILRUN ING3 IRS1 JHY KDR KRT8 LMCD1 LUC7L MAT2B NKX2-5 NSRP1 NUAK1 ODF2 ORC4 PADI4 PAK4 PCK1 PDGFRA PIP4K2C PPID PPP1R8 PRKCA PRKG2 PRR15 PRRG1 PSMD4 RABEP2 RBM8A RHBDD1 RIOK3 RPAP3 RPS10 RPS6KB2 SAMHD1 SERBP1 SKP1 STAC SYTL2 TBX5 TCEAL2 TCEANC TCP10L TMA7 TNIP2 TRUB1 TWF1 UBE2D3 UBQLN1 UBQLN2 WDSUB1
Entrez ID		55755	26260
HPRD ID		09740	16439
Ensembl ID		ENSG00000136861	ENSG00000147364
Uniprot IDs		A0A0A0MRG9 A0A8I5KXG0 A0A8I5QKL1 B3KVI2 B9EG74 Q96SN8	Q8TCJ0
PDB IDs		6X0V 8RX1 9G3Y 9G3Z 9G40 9H9P
Enriched GO Terms of Interacting Partners?		Microtubule Cytoskeleton Organization Growth Cone Microtubule-based Process Protein Kinase 5 Complex Cytoskeleton Organization Cerebellum Development Establishment Of Organelle Localization Perikaryon Negative Regulation Of Motor Neuron Apoptotic Process Hippocampus Development Cell Projection Organization ESC/E(Z) Complex Regulation Of Motor Neuron Apoptotic Process Neuromuscular Junction Regulation Of Plasma Membrane Bounded Cell Projection Organization Axon Layer Formation In Cerebral Cortex Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Regulation Of Neuron Projection Development Cell Projection Regulation Of Nervous System Development Retrograde Axonal Transport Attachment Of Mitotic Spindle Microtubules To Kinetochore Microtubule Plus-end Binding Microtubule Plus-end Negative Regulation Of Cellular Component Organization Positive Regulation Of Protein Targeting To Membrane Regulation Of Neuron Apoptotic Process Organelle Localization Regulation Of Microtubule-based Process Regulation Of Intracellular Transport Neuron Projection Regeneration Diol Metabolic Process Neuron Projection Development Regulation Of Cellular Component Organization Ionotropic Glutamate Receptor Binding Spinal Cord Development Endopeptidase Regulator Activity Regulation Of Cellular Localization Regulation Of Protein Targeting To Membrane Regulation Of Synapse Organization Organelle Organization Negative Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Regulation Of Postsynapse Organization Positive Regulation Of Presynaptic Cytosolic Calcium Concentration Positive Regulation Of Microtubule Polymerization DNA Endoreduplication Pre-mRNA Catabolic Process Positive Regulation Of Neurotrophin Production	Kinase Activity Protein Kinase Activity Protein Tyrosine Kinase Activity Nucleus Polyubiquitin Modification-dependent Protein Binding Cytosol ATP Binding Nucleotide Binding Protein Phosphorylation Phosphorylation Protein Serine/threonine Kinase Activity Apoptotic Process Atrioventricular Node Cell Fate Commitment Nucleoplasm Cell Death Programmed Cell Death Cytoplasm Protein Serine Kinase Activity His-Purkinje System Cell Differentiation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Macromolecule Metabolic Process Negative Regulation Of Signal Transduction Regulation Of Apoptotic Process Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Cardioblast Differentiation Atrioventricular Node Cell Development Bundle Of His Development Vascular Endothelial Growth Factor Binding Cellular Response To Stress Regulation Of Programmed Cell Death Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Signal Transduction Protein Metabolic Process Vascular Endothelial Growth Factor Receptor Activity Transferase Activity Proteasomal Protein Catabolic Process Cardiac Muscle Cell Fate Commitment Cardiac Ventricle Formation Negative Regulation Of Endothelial Cell Apoptotic Process Ubiquitin Ligase Complex Scaffold Activity Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Modification Process Atrial Septum Development Positive Regulation Of Natural Killer Cell Differentiation Ubiquitin-modified Protein Reader Activity ERAD Pathway Regulation Of Cell Communication Autophagosome Assembly
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?