CDK5RAP2 and MAGEH1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		CDK5RAP2	MAGEH1
Description		CDK5 regulatory subunit associated protein 2	MAGE family member H1
Image			No pdb structure
GO Annotations	Cellular Component	Pericentriolar Material Spindle Pole Gamma-tubulin Ring Complex Cytoplasm Golgi Apparatus Centrosome Microtubule Organizing Center Cytosol Cytoskeleton Microtubule Cell Junction Microtubule Plus-end Ciliary Basal Body Perinuclear Region Of Cytoplasm Extracellular Exosome Mitotic Spindle Pole	Nucleus
	Molecular Function	Transcription Cis-regulatory Region Binding Protein Binding Calmodulin Binding Microtubule Binding Tubulin Binding Protein Kinase Binding Gamma-tubulin Binding Protein-containing Complex Binding	Protein Binding
	Biological Process	Establishment Of Mitotic Spindle Orientation Microtubule Cytoskeleton Organization Microtubule Bundle Formation Chromosome Segregation Centrosome Cycle Centriole Replication Brain Development Neurogenesis Microtubule Organizing Center Organization Positive Regulation Of Microtubule Polymerization Regulation Of Neuron Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of DNA-templated Transcription Negative Regulation Of Centriole Replication Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint	Negative Regulation Of Transcription By RNA Polymerase II Apoptotic Process
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases		Primary microcephaly (MCPH)
GWAS		Asthma ( 27611488) Height ( 28552196) Photic sneeze reflex ( 27182965) Response to statin therapy ( 20339536) Rheumatoid arthritis ( 24782177)	Smoking initiation ( 24665060)
Interacting Genes		26 interacting genes: ABCA2 CDK5 CDK5R1 CLIP4 CRMP1 EEF1G ERG28 FBXO25 HAP1 KAT5 LRRK1 LUC7L2 MAGEH1 MAPRE1 NEFL PCBD1 PTN RBM48 REPS2 SENP2 STARD9 STK36 TBC1D4 TRIM37 TSNAX ZPR1	16 interacting genes: APP CDK5RAP2 DYRK1A ELN HMBOX1 KPNA2 MOAP1 NAP1L5 NGFR PIAS4 SH2B2 TADA3 TNFRSF1A TNIP1 TRIM41 ZSCAN9
Entrez ID		55755	28986
HPRD ID		09740	06633
Ensembl ID		ENSG00000136861	ENSG00000187601
Uniprot IDs		A0A0A0MRG9 A0A8I5KXG0 A0A8I5QKL1 B3KVI2 B9EG74 Q96SN8	Q9H213
PDB IDs		6X0V 8RX1 9G3Y 9G3Z 9G40 9H9P
Enriched GO Terms of Interacting Partners?		Microtubule Cytoskeleton Organization Growth Cone Microtubule-based Process Protein Kinase 5 Complex Cytoskeleton Organization Cerebellum Development Establishment Of Organelle Localization Perikaryon Negative Regulation Of Motor Neuron Apoptotic Process Hippocampus Development Cell Projection Organization ESC/E(Z) Complex Regulation Of Motor Neuron Apoptotic Process Neuromuscular Junction Regulation Of Plasma Membrane Bounded Cell Projection Organization Axon Layer Formation In Cerebral Cortex Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Regulation Of Neuron Projection Development Cell Projection Regulation Of Nervous System Development Retrograde Axonal Transport Attachment Of Mitotic Spindle Microtubules To Kinetochore Microtubule Plus-end Binding Microtubule Plus-end Negative Regulation Of Cellular Component Organization Positive Regulation Of Protein Targeting To Membrane Regulation Of Neuron Apoptotic Process Organelle Localization Regulation Of Microtubule-based Process Regulation Of Intracellular Transport Neuron Projection Regeneration Diol Metabolic Process Neuron Projection Development Regulation Of Cellular Component Organization Ionotropic Glutamate Receptor Binding Spinal Cord Development Endopeptidase Regulator Activity Regulation Of Cellular Localization Regulation Of Protein Targeting To Membrane Regulation Of Synapse Organization Organelle Organization Negative Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Regulation Of Postsynapse Organization Positive Regulation Of Presynaptic Cytosolic Calcium Concentration Positive Regulation Of Microtubule Polymerization DNA Endoreduplication Pre-mRNA Catabolic Process Positive Regulation Of Neurotrophin Production	Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Biosynthetic Process Central Nervous System Development Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Supramolecular Fiber Organization Non-canonical NF-kappaB Signal Transduction Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Macromolecule Biosynthetic Process Intracellular Signal Transduction Positive Regulation Of Inflammatory Response Regulation Of Response To Calcium Ion Amylin Binding Regulation Of Gene Expression Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Defense Response Histone H3T45 Kinase Activity Hair Follicle Development Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Cytokine-mediated Signaling Pathway Telomere-telomerase Complex Assembly Regulation Of Primary Metabolic Process Cellular Response To Amyloid-beta Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Cellular Response To Stress Tubulin Binding Response To Amyloid-beta Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import Regulation Of Microtubule Polymerization Entry Of Viral Genome Into Host Nucleus Through Nuclear Pore Complex Via Importin Positive Regulation Of Odontogenesis Of Dentin-containing Tooth Dorsal Aorta Development Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
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