PIAS2 and PLAGL1

Number of citations of the paper that reports this interaction (PubMedID 15208321)
0

Data Source:
BioGRID (pull down)

		PIAS2	PLAGL1
Description		protein inhibitor of activated STAT 2	PLAG1 like zinc finger 1
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm PML Body Nuclear Speck	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Nuclear Body
	Molecular Function	DNA Binding Transcription Coregulator Activity Transcription Corepressor Activity Protein Binding Zinc Ion Binding Transferase Activity SUMO Transferase Activity Ubiquitin Protein Ligase Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding SUMO Ligase Activity	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transforming Growth Factor Beta Receptor Signaling Pathway Protein Sumoylation Endoplasmic Reticulum Unfolded Protein Response Negative Regulation Of DNA-templated Transcription Regulation Of Macromolecule Metabolic Process SMAD Protein Signal Transduction Negative Regulation Of Androgen Receptor Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cytokine Production Regulation Of Immune System Process Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle
Pathways		Activation of anterior HOX genes in hindbrain development during early embryogenesis	TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
Drugs
Diseases			Transient neonatal diabetes mellitus (TNDM)
GWAS		Fruit consumption ( 32066663)	Anti-saccade response ( 29064472) Eosinophil percentage of granulocytes ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Heel bone mineral density x serum urate levels interaction ( 34046847) Lymphocyte percentage of white cells ( 32888494) Monocyte count ( 27863252 32888494) Monocyte percentage of white cells ( 27863252 32888494) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 27863252 32888494) Peanut allergy (maternal genetic effects) ( 29489655) Post bronchodilator FEV1/FVC ratio ( 26634245)
Interacting Genes		128 interacting genes: - ACY3 ADA AKT1 AR ATF2 C1QA C5orf24 CBS CCHCR1 CCNDBP1 CDCA8 CGGBP1 CHMP4B CLDN2 CREB1 CREBBP CTBP1 DDX39B DES DEUP1 DMC1 DNMT3A EDC3 ELK1 ESR1 ESR2 EXOSC8 FAM118B FKBP6 FLI1 GFAP GLUL GOLGA2 GRHL2 GRM8 GTF2I GTF2IRD1 HDAC3 HMBOX1 HMG20A HMG20B HMGXB4 HNRNPCL1 HNRNPUL1 HOMER1 HOOK1 HUWE1 IKZF1 IMPDH1 JUN KIFC3 LCE1E LCE2C LMNA LMNB1 MAPK14 MAPK8 MAPKAPK2 MBD1 MITF MLX MSX2 MX1 MX2 NAV2 NME7 NR3C1 PAICS PARK7 PAXIP1 PGR PHC1 PIAS1 PIAS4 PLAG1 PLAGL1 PML PRKAB2 PRKRA PRPH RFX2 RUFY1 RUNX1T1 SEC23A SIAH1 SIAH2 SMAD3 SMAD4 SNAI2 SNIP1 SOX5 SPATC1L SPINDOC SREBF2 STAT1 STAT4 STIP1 SUMO1 SUMO1P1 SUMO2 SUMO3 SYN3 TH TICAM2 TP53 TRAF2 TRAF3 TRAF5 TRIM23 TRIM27 TRIM50 TRIM55 TRIM63 TSR2 TXLNA UBASH3B UBE2I UBE2L3 UBQLN1 ZBED1 ZBTB16 ZBTB8A ZC3H10 ZFP42 ZNF319 ZNF451 ZNRD2	11 interacting genes: CREBBP DAXX EP300 KAT2B PIAS2 PML SMAD3 SUMO1 TLE5 TP53 UBE2I
Entrez ID		9063	5325
HPRD ID		06944	16010
Ensembl ID		ENSG00000078043	ENSG00000118495
Uniprot IDs		O75928 Q2TA77	A1YLA1 A1YLA2 Q9UM63
PDB IDs		2ASQ 4FO9
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Nucleus Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Enzyme Binding Negative Regulation Of Biosynthetic Process Negative Regulation Of DNA-templated Transcription DNA Binding Negative Regulation Of RNA Biosynthetic Process PML Body Protein Sumoylation Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nucleoplasm Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Activity Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Transcription Coactivator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Protein Binding Regulation Of Primary Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of DNA-templated Transcription DNA-binding Transcription Factor Activity, RNA Polymerase II-specific SUMO Transferase Activity Positive Regulation Of Transcription By RNA Polymerase II RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Zinc Ion Binding Positive Regulation Of Biosynthetic Process Cytoplasm Positive Regulation Of Macromolecule Metabolic Process Protein Modification By Small Protein Conjugation Ubiquitin Protein Ligase Binding Estrogen Response Element Binding Sequence-specific DNA Binding Positive Regulation Of Metabolic Process	Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process PML Body Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process N-terminal Peptidyl-lysine Acetylation Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Protein Stabilization Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Ubiquitin Protein Ligase Binding Transcription Coactivator Binding Protein Sumoylation N-terminal Protein Amino Acid Acetylation Peptidyl-lysine Acetylation Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Protein Stability P53 Binding Acetyltransferase Activity SUMO Transferase Activity Histone H3K27 Acetyltransferase Activity Regulation Of Transcription By RNA Polymerase II Histone Acetyltransferase Complex Protein-lysine-acetyltransferase Activity SMAD Protein Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Rhythmic Process Intracellular Signaling Cassette Histone H3K18 Acetyltransferase Activity Transcription Coactivator Activity Histone Acetyltransferase Activity Peptide Lactyltransferase (CoA-dependent) Activity Regulation Of Gene Expression Response To Hypoxia Protein Acetylation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Transcription Coregulator Activity Regulation Of Macromolecule Biosynthetic Process Response To Decreased Oxygen Levels Apoptotic Signaling Pathway Regulation Of Primary Metabolic Process Response To Oxygen Levels Chromatin Remodeling Cellular Response To Stress
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