PIAS2 and CHMP4B

Number of citations of the paper that reports this interaction (PMID 16730941)
46

Data Source:
HPRD (two hybrid)

		PIAS2	CHMP4B
Gene Name		protein inhibitor of activated STAT, 2	charged multivesicular body protein 4B
Image
Gene Ontology Annotations	Cellular Component	Nucleus PML Body Nuclear Speck	ESCRT III Complex Nucleus Cytoplasm Endosome Cytosol Cytoplasmic Side Of Plasma Membrane Midbody Late Endosome Membrane Extracellular Vesicular Exosome
	Molecular Function	DNA Binding Transcription Coactivator Activity Protein Binding Zinc Ion Binding Ligase Activity Ubiquitin Protein Ligase Binding Androgen Receptor Binding SUMO Ligase Activity	Protein Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Transcription, DNA-templated Protein Sumoylation Androgen Receptor Signaling Pathway Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Androgen Receptor Signaling Pathway	Cell Separation After Cytokinesis Posttranslational Protein Targeting To Membrane Nucleus Organization Vacuolar Transport Mitotic Metaphase Plate Congression Regulation Of Centrosome Duplication Viral Process Endosomal Transport Viral Life Cycle Maintenance Of Lens Transparency Viral Budding Via Host ESCRT Complex Viral Budding Regulation Of Viral Process Protein Homooligomerization Negative Regulation Of Cell Death Membrane Organization Ubiquitin-independent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Negative Regulation Of Neuron Death Regulation Of Mitotic Spindle Assembly Positive Regulation Of Viral Release From Host Cell Negative Regulation Of Autophagic Vacuole Assembly
Pathways			HIV Life Cycle Budding and maturation of HIV virion HIV Infection Endosomal Sorting Complex Required For Transport (ESCRT) Late Phase of HIV Life Cycle
Drugs
Diseases
GWAS			Stearic acid (18:0) plasma levels ( 23362303)
Protein-Protein Interactions		68 interactors: ACY3 ADA AKT1 AR C1QA CCHCR1 CCNDBP1 CHMP4B CLDN2 CTBP1 DDX39B ELK1 ESR1 ESR2 FLI1 GFAP GFI1 GLUL GOLGA2 GRM8 GTF2I GTF2IRD1 HDAC3 HUWE1 ITGB5 JUN MAPK8 MAPKAPK2 MBD1 MITF MSX2 MX2 MYCN NAV2 NR3C1 PARK7 PAXIP1 PGR PHC1 PIAS1 PIAS4 PLAG1 PLAGL1 PML PRKAB2 RUFY1 SIAH1 SIAH2 SMAD3 SMAD4 SNIP1 SREBF2 STAT4 SUMO1 SUMO1P1 SUMO2 SUMO3 TICAM2 TP53 TRIM23 TRIM27 TRIM55 TRIM63 TSR2 UBE2I ZBED1 ZBTB8A ZNF451	14 interactors: CHMP1B CHMP3 CHMP4A CHMP4C CHMP5 CHMP6 EXOSC9 HIPK2 PDCD6IP PIAS2 PTPN23 STAMBP UBE2I VPS4A
Entrez ID		9063	128866
HPRD ID		06944	16642
Ensembl ID		ENSG00000078043	ENSG00000101421
Uniprot IDs		O75928	Q9H444
PDB IDs		2ASQ 4FO9	3C3Q 3UM3 4ABM
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Cellular Response To Organic Substance Transcription, DNA-templated Response To Organic Substance RNA Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of RNA Metabolic Process Regulation Of Transcription, DNA-templated RNA Metabolic Process Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Gene Expression Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Protein Sumoylation Negative Regulation Of Nucleic Acid-templated Transcription Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Regulation Of Cell Death Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Cellular Metabolic Process Gland Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Protein Modification By Small Protein Conjugation Cellular Response To Lipid Macromolecule Biosynthetic Process Cellular Response To Stimulus Regulation Of Cellular Process Nitrogen Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Biosynthetic Process Cellular Metabolic Process Cellular Response To Organic Cyclic Compound Regulation Of Cell Proliferation Regulation Of Signaling Signaling	Cell Separation After Cytokinesis Cell Division Mitotic Metaphase Plate Congression Metaphase Plate Congression Establishment Of Chromosome Localization Nucleus Organization Vacuolar Transport Mitotic Sister Chromatid Segregation Viral Process Sister Chromatid Segregation Viral Life Cycle Chromosome Segregation Regulation Of Centrosome Duplication Regulation Of Centrosome Cycle Mitotic Nuclear Division Mitotic Cell Cycle Process Endosomal Transport Ubiquitin-independent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Mitotic Cell Cycle Viral Budding Via Host ESCRT Complex Regulation Of Mitotic Spindle Assembly Protein Transport Viral Budding Regulation Of Microtubule Cytoskeleton Organization Establishment Of Organelle Localization Regulation Of Spindle Assembly Establishment Of Protein Localization Cell Cycle Process Regulation Of Microtubule-based Process Regulation Of Mitotic Spindle Organization Organelle Localization Regulation Of Cell Cycle Process Protein Localization Membrane Organization Cell Cycle Virion Assembly Regulation Of Cell Cycle Regulation Of Cellular Component Organization Abscission Cellular Macromolecule Catabolic Process Regulation Of Cytoskeleton Organization Regulation Of Organelle Organization Positive Regulation Of Viral Release From Host Cell Intracellular Transport Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Cell Division Cellular Protein Catabolic Process Negative Regulation Of Cytokinesis Membrane Budding Organelle Organization
Tagcloud ?		293t acts alphaclass androgen ar chaperone clone27 coimmunoprecipitation colocalization coregulator cytoplasm e3 factorkappab hek hela libraries ligase modulates prefoldintype sumoylation termed transcript transducer trapped twohybrid ubiquitously uxt yeast	aculeiform adcc arg58his beaded bfsp1 bfsp2 cataract cerulean connexins coralliform cryaa cryba2 cryba4 crybb1 crybb3 cryga crygb crygc crygd crygs crystallins fasciculiform flaky gja3 gja8 lim2 macedonia pro23thr tmem114
Tagcloud (Difference) ?		293t acts alphaclass androgen ar chaperone clone27 coimmunoprecipitation colocalization coregulator cytoplasm e3 factorkappab hek hela libraries ligase modulates prefoldintype sumoylation termed transcript transducer trapped twohybrid ubiquitously uxt yeast	aculeiform adcc arg58his beaded bfsp1 bfsp2 cataract cerulean connexins coralliform cryaa cryba2 cryba4 crybb1 crybb3 cryga crygb crygc crygd crygs crystallins fasciculiform flaky gja3 gja8 lim2 macedonia pro23thr tmem114
Tagcloud (Intersection) ?