PIAS2 and MITF

Number of citations of the paper that reports this interaction (PMID 16029420)
15

Data Source:
BioGRID (pull down)

		PIAS2	MITF
Gene Name		protein inhibitor of activated STAT, 2	microphthalmia-associated transcription factor
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus PML Body Nuclear Speck	Nucleus Protein Complex
	Molecular Function	DNA Binding Transcription Coactivator Activity Protein Binding Zinc Ion Binding Ligase Activity Ubiquitin Protein Ligase Binding Androgen Receptor Binding SUMO Ligase Activity	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Chromatin Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Protein Dimerization Activity
	Biological Process	Transcription, DNA-templated Protein Sumoylation Androgen Receptor Signaling Pathway Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Androgen Receptor Signaling Pathway	Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Protein Complex Assembly Osteoclast Differentiation Melanocyte Differentiation Regulation Of Cell Proliferation Camera-type Eye Development Canonical Wnt Signaling Pathway Involved In Negative Regulation Of Apoptotic Process Cell Fate Commitment Regulation Of Osteoclast Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Bone Remodeling
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		68 interactors: ACY3 ADA AKT1 AR C1QA CCHCR1 CCNDBP1 CHMP4B CLDN2 CTBP1 DDX39B ELK1 ESR1 ESR2 FLI1 GFAP GFI1 GLUL GOLGA2 GRM8 GTF2I GTF2IRD1 HDAC3 HUWE1 ITGB5 JUN MAPK8 MAPKAPK2 MBD1 MITF MSX2 MX2 MYCN NAV2 NR3C1 PARK7 PAXIP1 PGR PHC1 PIAS1 PIAS4 PLAG1 PLAGL1 PML PRKAB2 RUFY1 SIAH1 SIAH2 SMAD3 SMAD4 SNIP1 SREBF2 STAT4 SUMO1 SUMO1P1 SUMO2 SUMO3 TICAM2 TP53 TRIM23 TRIM27 TRIM55 TRIM63 TSR2 UBE2I ZBED1 ZBTB8A ZNF451	28 interactors: APP CTNNB1 EBP EP300 FOS GSK3B HINT1 HK3 LEF1 MAPK1 MAPK14 MARK3 OTX2 PATZ1 PAX3 PAX6 PIAS1 PIAS2 PIAS3 PSMD14 RPS6KA1 SPI1 STUB1 SUMO1 TFE3 TFEB TFEC UBE2I
Entrez ID		9063	4286
HPRD ID		06944	01138
Ensembl ID		ENSG00000078043	ENSG00000187098
Uniprot IDs		O75928	B4DNC7 O75030 Q8WYR3
PDB IDs		2ASQ 4FO9
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Cellular Response To Organic Substance Transcription, DNA-templated Response To Organic Substance RNA Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of RNA Metabolic Process Regulation Of Transcription, DNA-templated RNA Metabolic Process Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Gene Expression Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Protein Sumoylation Negative Regulation Of Nucleic Acid-templated Transcription Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Regulation Of Cell Death Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Cellular Metabolic Process Gland Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Protein Modification By Small Protein Conjugation Cellular Response To Lipid Macromolecule Biosynthetic Process Cellular Response To Stimulus Regulation Of Cellular Process Nitrogen Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Biosynthetic Process Cellular Metabolic Process Cellular Response To Organic Cyclic Compound Regulation Of Cell Proliferation Regulation Of Signaling Signaling	Positive Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Nucleobase-containing Compound Metabolic Process Transcription, DNA-templated Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Biosynthetic Process Regulation Of Gene Expression Cellular Nitrogen Compound Metabolic Process Immune System Process RNA Metabolic Process Nitrogen Compound Metabolic Process Protein Sumoylation Regulation Of Metabolic Process Apoptotic Process Peptidyl-lysine Modification Programmed Cell Death Immune Response Regulation Of Cellular Protein Metabolic Process Cell Death Death Negative Regulation Of Cellular Metabolic Process Cellular Metabolic Process Regulation Of Protein Metabolic Process Peptidyl-amino Acid Modification Cellular Macromolecule Biosynthetic Process Regulation Of Cell Differentiation Macromolecule Biosynthetic Process Cellular Protein Modification Process Negative Regulation Of Biosynthetic Process Innate Immune Response Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Myeloid Cell Differentiation Biosynthetic Process Regulation Of Immune System Process Organ Development Negative Regulation Of Transcription, DNA-templated
Tagcloud ?		293t acts alphaclass androgen ar chaperone clone27 coimmunoprecipitation colocalization coregulator cytoplasm e3 factorkappab hek hela libraries ligase modulates prefoldintype sumoylation termed transcript transducer trapped twohybrid ubiquitously uxt yeast	agricultural ammonium b16 coloring cosmetic cosmetics downregulate dyes f10 follicles hair hypopigmenting industry lawsone melanin melanogenesis melanoma microphthalmia modern mushroom permanent persulfate products proved resorcinol semi sodium temporary tyrosinase
Tagcloud (Difference) ?		293t acts alphaclass androgen ar chaperone clone27 coimmunoprecipitation colocalization coregulator cytoplasm e3 factorkappab hek hela libraries ligase modulates prefoldintype sumoylation termed transcript transducer trapped twohybrid ubiquitously uxt yeast	agricultural ammonium b16 coloring cosmetic cosmetics downregulate dyes f10 follicles hair hypopigmenting industry lawsone melanin melanogenesis melanoma microphthalmia modern mushroom permanent persulfate products proved resorcinol semi sodium temporary tyrosinase
Tagcloud (Intersection) ?