PIAS2 and PLAG1

Number of citations of the paper that reports this interaction (PubMedID 15208321)
0

Data Source:
BioGRID (pull down)

		PIAS2	PLAG1
Description		protein inhibitor of activated STAT 2	PLAG1 zinc finger
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm PML Body Nuclear Speck	Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Nuclear Body Nuclear Speck
	Molecular Function	DNA Binding Transcription Coregulator Activity Transcription Corepressor Activity Protein Binding Zinc Ion Binding Transferase Activity SUMO Transferase Activity Ubiquitin Protein Ligase Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding SUMO Ligase Activity	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Zinc Ion Binding Metal Ion Binding
	Biological Process	DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transforming Growth Factor Beta Receptor Signaling Pathway Protein Sumoylation Endoplasmic Reticulum Unfolded Protein Response Negative Regulation Of DNA-templated Transcription Regulation Of Macromolecule Metabolic Process SMAD Protein Signal Transduction Negative Regulation Of Androgen Receptor Signaling Pathway	Regulation Of DNA-templated Transcription Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Gland Morphogenesis Multicellular Organism Growth Organ Growth Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Glial Cell Proliferation Prostate Gland Growth
Pathways		Activation of anterior HOX genes in hindbrain development during early embryogenesis
Drugs
Diseases
GWAS		Fruit consumption ( 32066663)	Appendicular lean mass ( 33097823) Birth weight ( 31043758) Heel bone mineral density ( 30598549) Height ( 19343178 31562340 28552196 25429064 25282103 20189936 19893584 19396169 18391951) Hip circumference adjusted for BMI ( 25673412 34021172) Monocyte count ( 32888494) Plateletcrit ( 32888494) Refractive error ( 32231278)
Interacting Genes		128 interacting genes: - ACY3 ADA AKT1 AR ATF2 C1QA C5orf24 CBS CCHCR1 CCNDBP1 CDCA8 CGGBP1 CHMP4B CLDN2 CREB1 CREBBP CTBP1 DDX39B DES DEUP1 DMC1 DNMT3A EDC3 ELK1 ESR1 ESR2 EXOSC8 FAM118B FKBP6 FLI1 GFAP GLUL GOLGA2 GRHL2 GRM8 GTF2I GTF2IRD1 HDAC3 HMBOX1 HMG20A HMG20B HMGXB4 HNRNPCL1 HNRNPUL1 HOMER1 HOOK1 HUWE1 IKZF1 IMPDH1 JUN KIFC3 LCE1E LCE2C LMNA LMNB1 MAPK14 MAPK8 MAPKAPK2 MBD1 MITF MLX MSX2 MX1 MX2 NAV2 NME7 NR3C1 PAICS PARK7 PAXIP1 PGR PHC1 PIAS1 PIAS4 PLAG1 PLAGL1 PML PRKAB2 PRKRA PRPH RFX2 RUFY1 RUNX1T1 SEC23A SIAH1 SIAH2 SMAD3 SMAD4 SNAI2 SNIP1 SOX5 SPATC1L SPINDOC SREBF2 STAT1 STAT4 STIP1 SUMO1 SUMO1P1 SUMO2 SUMO3 SYN3 TH TICAM2 TP53 TRAF2 TRAF3 TRAF5 TRIM23 TRIM27 TRIM50 TRIM55 TRIM63 TSR2 TXLNA UBASH3B UBE2I UBE2L3 UBQLN1 ZBED1 ZBTB16 ZBTB8A ZC3H10 ZFP42 ZNF319 ZNF451 ZNRD2	5 interacting genes: KPNA2 PIAS1 PIAS2 PIAS4 SMAD3
Entrez ID		9063	5324
HPRD ID		06944	04321
Ensembl ID		ENSG00000078043	ENSG00000181690
Uniprot IDs		O75928 Q2TA77	Q6DJT9
PDB IDs		2ASQ 4FO9
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Nucleus Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Enzyme Binding Negative Regulation Of Biosynthetic Process Negative Regulation Of DNA-templated Transcription DNA Binding Negative Regulation Of RNA Biosynthetic Process PML Body Protein Sumoylation Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nucleoplasm Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Activity Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Transcription Coactivator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Protein Binding Regulation Of Primary Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of DNA-templated Transcription DNA-binding Transcription Factor Activity, RNA Polymerase II-specific SUMO Transferase Activity Positive Regulation Of Transcription By RNA Polymerase II RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Zinc Ion Binding Positive Regulation Of Biosynthetic Process Cytoplasm Positive Regulation Of Macromolecule Metabolic Process Protein Modification By Small Protein Conjugation Ubiquitin Protein Ligase Binding Estrogen Response Element Binding Sequence-specific DNA Binding Positive Regulation Of Metabolic Process	SUMO Ligase Activity SUMO Transferase Activity Protein Sumoylation Ubiquitin Protein Ligase Binding PML Body Transcription Coregulator Activity Positive Regulation Of Protein Sumoylation Transcription Corepressor Activity Regulation Of Protein Sumoylation SMAD Protein Signal Transduction Chromatin Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Lung Blood Pressure Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Mineralocorticoid Receptor Binding Regulation Of RNA Metabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Entry Of Viral Genome Into Host Nucleus Through Nuclear Pore Complex Via Importin Positive Regulation Of Transforming Growth Factor Beta3 Production Positive Regulation Of Post-translational Protein Modification Limb Epidermis Development Protein Modification By Small Protein Conjugation Regulation Of DNA Recombination Nucleoplasm DNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleic Acid Metabolic Process Sterol Response Element Binding Zinc Ion Binding Paraxial Mesoderm Morphogenesis Cell Surface Receptor Signaling Pathway Signal Transduction Intracellular Signaling Cassette Viral Penetration Into Host Nucleus DNA Binding Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Regulation Of Lung Blood Pressure DNA-binding Transcription Factor Binding Post-translational Protein Modification Positive Regulation Of Keratinocyte Apoptotic Process Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of Biosynthetic Process
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