PIAS2 and SIAH2

Number of citations of the paper that reports this interaction (PubMedID 17533377)
0

Data Source:
BioGRID (two hybrid)

		PIAS2	SIAH2
Description		protein inhibitor of activated STAT 2	siah E3 ubiquitin protein ligase 2
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm PML Body Nuclear Speck	Nucleus Nucleoplasm Cytoplasm Early Endosome Cytosol Neuronal Cell Body
	Molecular Function	DNA Binding Transcription Coregulator Activity Transcription Corepressor Activity Protein Binding Zinc Ion Binding Transferase Activity SUMO Transferase Activity Ubiquitin Protein Ligase Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding SUMO Ligase Activity	Transcription Corepressor Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Ubiquitin Conjugating Enzyme Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transforming Growth Factor Beta Receptor Signaling Pathway Protein Sumoylation Endoplasmic Reticulum Unfolded Protein Response Negative Regulation Of DNA-templated Transcription Regulation Of Macromolecule Metabolic Process SMAD Protein Signal Transduction Negative Regulation Of Androgen Receptor Signaling Pathway	Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Small GTPase-mediated Signal Transduction Protein Ubiquitination Regulation Of Protein Ubiquitination Regulation Of Circadian Rhythm Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of DNA-templated Transcription Rhythmic Process Canonical Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Amyloid Fibril Formation Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Activation of anterior HOX genes in hindbrain development during early embryogenesis	Netrin-1 signaling Ub-specific processing proteases Amyloid fiber formation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Fruit consumption ( 32066663)	BRCA1/2-negative high-risk breast cancer ( 30323354) Breast cancer ( 22951594 31757997)
Interacting Genes		128 interacting genes: - ACY3 ADA AKT1 AR ATF2 C1QA C5orf24 CBS CCHCR1 CCNDBP1 CDCA8 CGGBP1 CHMP4B CLDN2 CREB1 CREBBP CTBP1 DDX39B DES DEUP1 DMC1 DNMT3A EDC3 ELK1 ESR1 ESR2 EXOSC8 FAM118B FKBP6 FLI1 GFAP GLUL GOLGA2 GRHL2 GRM8 GTF2I GTF2IRD1 HDAC3 HMBOX1 HMG20A HMG20B HMGXB4 HNRNPCL1 HNRNPUL1 HOMER1 HOOK1 HUWE1 IKZF1 IMPDH1 JUN KIFC3 LCE1E LCE2C LMNA LMNB1 MAPK14 MAPK8 MAPKAPK2 MBD1 MITF MLX MSX2 MX1 MX2 NAV2 NME7 NR3C1 PAICS PARK7 PAXIP1 PGR PHC1 PIAS1 PIAS4 PLAG1 PLAGL1 PML PRKAB2 PRKRA PRPH RFX2 RUFY1 RUNX1T1 SEC23A SIAH1 SIAH2 SMAD3 SMAD4 SNAI2 SNIP1 SOX5 SPATC1L SPINDOC SREBF2 STAT1 STAT4 STIP1 SUMO1 SUMO1P1 SUMO2 SUMO3 SYN3 TH TICAM2 TP53 TRAF2 TRAF3 TRAF5 TRIM23 TRIM27 TRIM50 TRIM55 TRIM63 TSR2 TXLNA UBASH3B UBE2I UBE2L3 UBQLN1 ZBED1 ZBTB16 ZBTB8A ZC3H10 ZFP42 ZNF319 ZNF451 ZNRD2	46 interacting genes: AFF1 AKR1C3 ATN1 CACYBP CCAR2 CCBE1 CHEK2 DCC DLST DYRK2 EEF1D EGLN3 HIPK2 HIPK3 LATS2 MYD88 NRF1 OPRM1 PEG10 PEG3 PIAS2 PIAS3 PML POU2AF1 PSMD4 RBBP8 SETD2 SNCA SNCAIP SPRY2 STAT3 SYP TINF2 TP53BP2 TPX2 TRAF2 UBE2D1 UBE2D2 UBE2D3 UBE2I UBE2L6 UBE2N UBE2V2 USP13 USP19 VAV1
Entrez ID		9063	6478
HPRD ID		06944	03737
Ensembl ID		ENSG00000078043	ENSG00000181788
Uniprot IDs		O75928 Q2TA77	O43255
PDB IDs		2ASQ 4FO9	5H9M
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Nucleus Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Enzyme Binding Negative Regulation Of Biosynthetic Process Negative Regulation Of DNA-templated Transcription DNA Binding Negative Regulation Of RNA Biosynthetic Process PML Body Protein Sumoylation Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nucleoplasm Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Activity Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Transcription Coactivator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Protein Binding Regulation Of Primary Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of DNA-templated Transcription DNA-binding Transcription Factor Activity, RNA Polymerase II-specific SUMO Transferase Activity Positive Regulation Of Transcription By RNA Polymerase II RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Zinc Ion Binding Positive Regulation Of Biosynthetic Process Cytoplasm Positive Regulation Of Macromolecule Metabolic Process Protein Modification By Small Protein Conjugation Ubiquitin Protein Ligase Binding Estrogen Response Element Binding Sequence-specific DNA Binding Positive Regulation Of Metabolic Process	Cell Death Nucleoplasm Apoptotic Process Programmed Cell Death Nucleus Regulation Of Primary Metabolic Process Protein Modification Process Post-translational Protein Modification Regulation Of Metabolic Process Protein Modification By Small Protein Conjugation Ubiquitin Conjugating Enzyme Activity Regulation Of Macromolecule Metabolic Process Protein Polyubiquitination Regulation Of Cell Communication Regulation Of Signaling Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Positive Regulation Of Macromolecule Metabolic Process SUMO Transferase Activity Positive Regulation Of Metabolic Process Cellular Response To Stress Protein Metabolic Process PML Body Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Macromolecule Metabolic Process Transferase Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cellular Response To Stress Ubiquitin Protein Ligase Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Intracellular Signal Transduction Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of RNA Metabolic Process Cytosol Negative Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling DNA Damage Response Positive Regulation Of Intracellular Signal Transduction Regulation Of Protein Modification Process Intrinsic Apoptotic Signaling Pathway Signal Transduction By P53 Class Mediator Proteolysis Involved In Protein Catabolic Process Protein Sumoylation Negative Regulation Of Signal Transduction Regulation Of Macromolecule Biosynthetic Process Macromolecule Catabolic Process Negative Regulation Of Macromolecule Metabolic Process
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?