Wiki-Pi
About
Search
People
Updates
Search
PIAS2 and MAPKAPK2
Number of citations of the paper that reports this interaction (PubMedID
23202365
)
20
Data Source:
BioGRID
(enzymatic study)
PIAS2
MAPKAPK2
Description
protein inhibitor of activated STAT 2
MAPK activated protein kinase 2
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
PML Body
Nuclear Speck
Nucleus
Nucleoplasm
Cytoplasm
Centrosome
Cytosol
Ciliary Basal Body
Extracellular Exosome
Molecular Function
DNA Binding
Transcription Coregulator Activity
Transcription Corepressor Activity
Protein Binding
Zinc Ion Binding
Transferase Activity
SUMO Transferase Activity
Ubiquitin Protein Ligase Binding
Metal Ion Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
SUMO Ligase Activity
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Calcium/calmodulin-dependent Protein Kinase Activity
Protein Binding
Calmodulin Binding
ATP Binding
Calcium-dependent Protein Serine/threonine Kinase Activity
Kinase Activity
Transferase Activity
Mitogen-activated Protein Kinase Binding
Protein Serine Kinase Activity
Biological Process
DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Transforming Growth Factor Beta Receptor Signaling Pathway
Protein Sumoylation
Endoplasmic Reticulum Unfolded Protein Response
Negative Regulation Of DNA-templated Transcription
Regulation Of Macromolecule Metabolic Process
SMAD Protein Signal Transduction
Negative Regulation Of Androgen Receptor Signaling Pathway
MAPK Cascade
Toll-like Receptor Signaling Pathway
Leukotriene Metabolic Process
Inflammatory Response
DNA Damage Response
Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Response To Lipopolysaccharide
Regulation Of Interleukin-6 Production
Regulation Of Tumor Necrosis Factor Production
Positive Regulation Of Tumor Necrosis Factor Production
Response To Cytokine
Intracellular Signal Transduction
Cellular Response To Vascular Endothelial Growth Factor Stimulus
P38MAPK Cascade
Regulation Of MRNA Stability
Macropinocytosis
Vascular Endothelial Growth Factor Receptor Signaling Pathway
MRNA Stabilization
Inner Ear Development
Positive Regulation Of Macrophage Cytokine Production
3'-UTR-mediated MRNA Stabilization
Regulation Of Cellular Response To Heat
Pathways
Activation of anterior HOX genes in hindbrain development during early embryogenesis
p38MAPK events
CREB phosphorylation
Synthesis of Leukotrienes (LT) and Eoxins (EX)
Oxidative Stress Induced Senescence
Regulation of HSF1-mediated heat shock response
VEGFA-VEGFR2 Pathway
activated TAK1 mediates p38 MAPK activation
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
Regulation of TNFR1 signaling
Drugs
Staurosporine
3-{[(1R)-1-phenylethyl]amino}-4-(pyridin-4-ylamino)cyclobut-3-ene-1,2-dione
(4R)-N-[4-({[2-(DIMETHYLAMINO)ETHYL]AMINO}CARBONYL)-1,3-THIAZOL-2-YL]-4-METHYL-1-OXO-2,3,4,9-TETRAHYDRO-1H-BETA-CARBOLINE-6-CARBOXAMIDE
(10R)-10-methyl-3-(6-methylpyridin-3-yl)-9,10,11,12-tetrahydro-8H-[1,4]diazepino[5',6':4,5]thieno[3,2-f]quinolin-8-one
(3R)-3-(aminomethyl)-9-methoxy-1,2,3,4-tetrahydro-5H-[1]benzothieno[3,2-e][1,4]diazepin-5-one
2-[2-(2-FLUOROPHENYL)PYRIDIN-4-YL]-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE
2-(2-QUINOLIN-3-YLPYRIDIN-4-YL)-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE
Diseases
GWAS
Fruit consumption (
32066663
)
Inflammatory bowel disease (
23128233
)
Itch intensity from mosquito bite (
28199695
)
Mean corpuscular hemoglobin (
32888494
)
Interacting Genes
128 interacting genes:
-
ACY3
ADA
AKT1
AR
ATF2
C1QA
C5orf24
CBS
CCHCR1
CCNDBP1
CDCA8
CGGBP1
CHMP4B
CLDN2
CREB1
CREBBP
CTBP1
DDX39B
DES
DEUP1
DMC1
DNMT3A
EDC3
ELK1
ESR1
ESR2
EXOSC8
FAM118B
FKBP6
FLI1
GFAP
GLUL
GOLGA2
GRHL2
GRM8
GTF2I
GTF2IRD1
HDAC3
HMBOX1
HMG20A
HMG20B
HMGXB4
HNRNPCL1
HNRNPUL1
HOMER1
HOOK1
HUWE1
IKZF1
IMPDH1
JUN
KIFC3
LCE1E
LCE2C
LMNA
LMNB1
MAPK14
MAPK8
MAPKAPK2
MBD1
MITF
MLX
MSX2
MX1
MX2
NAV2
NME7
NR3C1
PAICS
PARK7
PAXIP1
PGR
PHC1
PIAS1
PIAS4
PLAG1
PLAGL1
PML
PRKAB2
PRKRA
PRPH
RFX2
RUFY1
RUNX1T1
SEC23A
SIAH1
SIAH2
SMAD3
SMAD4
SNAI2
SNIP1
SOX5
SPATC1L
SPINDOC
SREBF2
STAT1
STAT4
STIP1
SUMO1
SUMO1P1
SUMO2
SUMO3
SYN3
TH
TICAM2
TP53
TRAF2
TRAF3
TRAF5
TRIM23
TRIM27
TRIM50
TRIM55
TRIM63
TSR2
TXLNA
UBASH3B
UBE2I
UBE2L3
UBQLN1
ZBED1
ZBTB16
ZBTB8A
ZC3H10
ZFP42
ZNF319
ZNF451
ZNRD2
42 interacting genes:
AGO2
AKT1
ALOX5
ARPC5
ATF1
BAG2
BCL2L1
BECN1
CDC25B
CEP131
CREB1
DDX5
DES
EEF2K
ETV1
HNRNPA0
HSF1
HSPB1
LIMK1
LSP1
MAP2K6
MAPK14
MAPK3
MDM2
PABPC1
PARN
PHC2
PIAS2
RCSD1
SHC1
SRF
STAT3
TCF3
TH
TRIM28
TRIM29
TSC2
UBE2J1
WASF1
YWHAZ
ZFP36
ZFP36L1
Entrez ID
9063
9261
HPRD ID
06944
11882
Ensembl ID
ENSG00000078043
ENSG00000162889
Uniprot IDs
O75928
Q2TA77
P49137
PDB IDs
2ASQ
4FO9
1KWP
1NXK
1NY3
2JBO
2JBP
2OKR
2ONL
2OZA
2P3G
2PZY
3A2C
3FPM
3FYJ
3FYK
3GOK
3KA0
3KC3
3KGA
3M2W
3M42
3R2B
3R2Y
3R30
3WI6
4TYH
6T8X
6TCA
7NRY
8XU4
8XX1
Enriched GO Terms of Interacting Partners
?
Identical Protein Binding
Nucleus
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Enzyme Binding
Negative Regulation Of Biosynthetic Process
Negative Regulation Of DNA-templated Transcription
DNA Binding
Negative Regulation Of RNA Biosynthetic Process
PML Body
Protein Sumoylation
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Nucleoplasm
Regulation Of RNA Metabolic Process
DNA-binding Transcription Factor Activity
Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Transcription By RNA Polymerase II
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Gene Expression
Transcription Coactivator Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Chromatin
Protein Binding
Regulation Of Primary Metabolic Process
Positive Regulation Of RNA Metabolic Process
Positive Regulation Of RNA Biosynthetic Process
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of DNA-templated Transcription
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
SUMO Transferase Activity
Positive Regulation Of Transcription By RNA Polymerase II
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Regulation Of Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Zinc Ion Binding
Positive Regulation Of Biosynthetic Process
Cytoplasm
Positive Regulation Of Macromolecule Metabolic Process
Protein Modification By Small Protein Conjugation
Ubiquitin Protein Ligase Binding
Estrogen Response Element Binding
Sequence-specific DNA Binding
Positive Regulation Of Metabolic Process
Negative Regulation Of Metabolic Process
Response To Growth Factor
Negative Regulation Of RNA Metabolic Process
Response To Stress
Cellular Response To Growth Factor Stimulus
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Catabolic Process
Intracellular Signal Transduction
Negative Regulation Of Macromolecule Metabolic Process
Protein Kinase Binding
Intracellular Signaling Cassette
RNA Stabilization
Regulation Of RNA Stability
Response To Decreased Oxygen Levels
Negative Regulation Of RNA Catabolic Process
Regulation Of Gene Expression
P38MAPK Cascade
Positive Regulation Of Catabolic Process
Regulation Of Macromolecule Biosynthetic Process
Response To Oxygen Levels
Regulation Of Metabolic Process
Nucleus
Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
Post-transcriptional Regulation Of Gene Expression
Regulation Of Cell Population Proliferation
Regulation Of MRNA Stability
Cytosol
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Response To Peptide
RNA Metabolic Process
Regulation Of MRNA Metabolic Process
Animal Organ Development
MAPK Cascade
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of RNA Metabolic Process
Regulation Of Macromolecule Metabolic Process
Response To Epidermal Growth Factor
Positive Regulation Of Biosynthetic Process
Response To Nutrient Levels
Regulation Of Multicellular Organismal Process
Negative Regulation Of Autophagy
Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
Macromolecule Metabolic Process
Positive Regulation Of Developmental Process
Regulation Of Cellular Component Organization
Identical Protein Binding
Regulation Of Primary Metabolic Process
Nucleic Acid Metabolic Process
Cellular Response To Stress
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?