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PIAS2 and C1QA
Number of citations of the paper that reports this interaction (PubMedID
21988832
)
38
Data Source:
BioGRID
(two hybrid)
PIAS2
C1QA
Description
protein inhibitor of activated STAT 2
complement C1q A chain
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
PML Body
Nuclear Speck
Extracellular Region
Collagen Trimer
Complement Component C1 Complex
Cell Surface
Extracellular Matrix
Synapse
Complement Component C1q Complex
Postsynapse
Extrinsic Component Of Presynaptic Membrane
Extrinsic Component Of Postsynaptic Membrane
Glutamatergic Synapse
Symbiont Cell Surface
Molecular Function
DNA Binding
Transcription Coregulator Activity
Transcription Corepressor Activity
Protein Binding
Zinc Ion Binding
Transferase Activity
SUMO Transferase Activity
Ubiquitin Protein Ligase Binding
Metal Ion Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
SUMO Ligase Activity
Amyloid-beta Binding
Phosphatidylserine Binding
IgM Binding
Protein Binding
IgG Binding
Biological Process
DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Transforming Growth Factor Beta Receptor Signaling Pathway
Protein Sumoylation
Endoplasmic Reticulum Unfolded Protein Response
Negative Regulation Of DNA-templated Transcription
Regulation Of Macromolecule Metabolic Process
SMAD Protein Signal Transduction
Negative Regulation Of Androgen Receptor Signaling Pathway
Microglial Cell Activation
Immune System Process
Complement Activation
Complement Activation, Classical Pathway
Cell-cell Signaling
Neuron Remodeling
Innate Immune Response
Astrocyte Activation
Synapse Organization
Synapse Pruning
Complement-mediated Synapse Pruning
Vertebrate Eye-specific Patterning
Pathways
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Initial triggering of complement
Classical antibody-mediated complement activation
Regulation of Complement cascade
Drugs
Cetuximab
Etanercept
Palivizumab
Daclizumab
Bevacizumab
Diseases
Classic complement pathway component defects, including the following eight diseases: C1q alpha-chain deficiency; C1q beta-chain deficiency; C1q gamma-chain deficiency; C1r deficiency; C1s deficiency; C2 deficiency; C3 deficiency; C4 deficiency
GWAS
Fruit consumption (
32066663
)
Inflammatory biomarkers (multivariate analysis) (
33110245
)
Interacting Genes
128 interacting genes:
-
ACY3
ADA
AKT1
AR
ATF2
C1QA
C5orf24
CBS
CCHCR1
CCNDBP1
CDCA8
CGGBP1
CHMP4B
CLDN2
CREB1
CREBBP
CTBP1
DDX39B
DES
DEUP1
DMC1
DNMT3A
EDC3
ELK1
ESR1
ESR2
EXOSC8
FAM118B
FKBP6
FLI1
GFAP
GLUL
GOLGA2
GRHL2
GRM8
GTF2I
GTF2IRD1
HDAC3
HMBOX1
HMG20A
HMG20B
HMGXB4
HNRNPCL1
HNRNPUL1
HOMER1
HOOK1
HUWE1
IKZF1
IMPDH1
JUN
KIFC3
LCE1E
LCE2C
LMNA
LMNB1
MAPK14
MAPK8
MAPKAPK2
MBD1
MITF
MLX
MSX2
MX1
MX2
NAV2
NME7
NR3C1
PAICS
PARK7
PAXIP1
PGR
PHC1
PIAS1
PIAS4
PLAG1
PLAGL1
PML
PRKAB2
PRKRA
PRPH
RFX2
RUFY1
RUNX1T1
SEC23A
SIAH1
SIAH2
SMAD3
SMAD4
SNAI2
SNIP1
SOX5
SPATC1L
SPINDOC
SREBF2
STAT1
STAT4
STIP1
SUMO1
SUMO1P1
SUMO2
SUMO3
SYN3
TH
TICAM2
TP53
TRAF2
TRAF3
TRAF5
TRIM23
TRIM27
TRIM50
TRIM55
TRIM63
TSR2
TXLNA
UBASH3B
UBE2I
UBE2L3
UBQLN1
ZBED1
ZBTB16
ZBTB8A
ZC3H10
ZFP42
ZNF319
ZNF451
ZNRD2
31 interacting genes:
APCS
BAG6
C1QB
C1QBP
C1QC
C1R
C1S
CD93
COL2A1
CR1
CRP
CSPG4
DCN
FN1
GNPNAT1
HIPK3
HMGB1
HRG
HSPB2
NLGN3
PIAS2
PPP1CA
PPP1CC
PTX3
SGTA
SGTB
SLC25A47
TXN
UBQLN1
UBQLN2
USP40
Entrez ID
9063
712
HPRD ID
06944
00393
Ensembl ID
ENSG00000078043
ENSG00000173372
Uniprot IDs
O75928
Q2TA77
P02745
PDB IDs
2ASQ
4FO9
1PK6
2JG8
2JG9
2WNU
2WNV
5HKJ
5HZF
6FCZ
6Z6V
9C9L
9C9U
Enriched GO Terms of Interacting Partners
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Identical Protein Binding
Nucleus
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Enzyme Binding
Negative Regulation Of Biosynthetic Process
Negative Regulation Of DNA-templated Transcription
DNA Binding
Negative Regulation Of RNA Biosynthetic Process
PML Body
Protein Sumoylation
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Nucleoplasm
Regulation Of RNA Metabolic Process
DNA-binding Transcription Factor Activity
Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Transcription By RNA Polymerase II
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Gene Expression
Transcription Coactivator Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Chromatin
Protein Binding
Regulation Of Primary Metabolic Process
Positive Regulation Of RNA Metabolic Process
Positive Regulation Of RNA Biosynthetic Process
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of DNA-templated Transcription
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
SUMO Transferase Activity
Positive Regulation Of Transcription By RNA Polymerase II
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Regulation Of Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Zinc Ion Binding
Positive Regulation Of Biosynthetic Process
Cytoplasm
Positive Regulation Of Macromolecule Metabolic Process
Protein Modification By Small Protein Conjugation
Ubiquitin Protein Ligase Binding
Estrogen Response Element Binding
Sequence-specific DNA Binding
Positive Regulation Of Metabolic Process
Complement Component C1q Complex Binding
Complement Activation, Classical Pathway
Complement Component C1 Complex
Complement Activation
Blood Microparticle
Cell Surface
Opsonization
Immune Effector Process
Positive Regulation Of ERAD Pathway
Symbiont Cell Surface
Defense Response To Symbiont
Defense Response To Other Organism
Regulation Of ERAD Pathway
Innate Immune Response
Regulation Of Protein Metabolic Process
Extracellular Region
Response To Stress
Humoral Immune Response
Virion Binding
Activation Of Immune Response
Extracellular Matrix
Positive Regulation Of Response To Endoplasmic Reticulum Stress
Post-translational Protein Targeting To Endoplasmic Reticulum Membrane
Response To External Biotic Stimulus
Regulation Of Immune System Process
Immune System Process
Positive Regulation Of Immune Response
Defense Response
Response To Other Organism
Negative Regulation By Host Of Viral Glycoprotein Metabolic Process
TRC Complex
Regulation Of Immune Response
Immune Response
Extracellular Space
Identical Protein Binding
Negative Regulation Of Endothelial Cell Migration
Complement Component C1q Complex
Positive Regulation Of Immune System Process
Protein Targeting To ER
Regulation Of Response To Endoplasmic Reticulum Stress
ERAD Pathway
Regulation Of Multicellular Organismal Development
Establishment Of Protein Localization To Endoplasmic Reticulum
IgM Binding
Positive Regulation Of Proteolysis
Negative Regulation Of Immune System Process
Polyubiquitin Modification-dependent Protein Binding
Acute-phase Response
Positive Regulation Of Proteasomal Protein Catabolic Process
Postsynapse
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Tagcloud (Intersection)
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