PIAS2 and MX2

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		PIAS2	MX2
Gene Name		protein inhibitor of activated STAT, 2	MX dynamin-like GTPase 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus PML Body Nuclear Speck	Nucleus Nuclear Pore Cytoplasm Cytosol
	Molecular Function	DNA Binding Transcription Coactivator Activity Protein Binding Zinc Ion Binding Ligase Activity Ubiquitin Protein Ligase Binding Androgen Receptor Binding SUMO Ligase Activity	GTPase Activity GTP Binding
	Biological Process	Transcription, DNA-templated Protein Sumoylation Androgen Receptor Signaling Pathway Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Androgen Receptor Signaling Pathway	Defense Response Metabolic Process Response To Virus Protein Transport Cytokine-mediated Signaling Pathway Response To Interferon-alpha Regulation Of Nucleocytoplasmic Transport MRNA Transport Defense Response To Virus Regulation Of Cell Cycle Type I Interferon Signaling Pathway
Pathways			ISG15 antiviral mechanism Interferon Signaling Cytokine Signaling in Immune system Interferon alpha/beta signaling Antiviral mechanism by IFN-stimulated genes
Drugs
Diseases
GWAS			Melanoma ( 21983787)
Protein-Protein Interactions		68 interactors: ACY3 ADA AKT1 AR C1QA CCHCR1 CCNDBP1 CHMP4B CLDN2 CTBP1 DDX39B ELK1 ESR1 ESR2 FLI1 GFAP GFI1 GLUL GOLGA2 GRM8 GTF2I GTF2IRD1 HDAC3 HUWE1 ITGB5 JUN MAPK8 MAPKAPK2 MBD1 MITF MSX2 MX2 MYCN NAV2 NR3C1 PARK7 PAXIP1 PGR PHC1 PIAS1 PIAS4 PLAG1 PLAGL1 PML PRKAB2 RUFY1 SIAH1 SIAH2 SMAD3 SMAD4 SNIP1 SREBF2 STAT4 SUMO1 SUMO1P1 SUMO2 SUMO3 TICAM2 TP53 TRIM23 TRIM27 TRIM55 TRIM63 TSR2 UBE2I ZBED1 ZBTB8A ZNF451	3 interactors: ATRIP EHMT2 PIAS2
Entrez ID		9063	4600
HPRD ID		06944	01001
Ensembl ID		ENSG00000078043	ENSG00000183486
Uniprot IDs		O75928	P20592
PDB IDs		2ASQ 4FO9
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Cellular Response To Organic Substance Transcription, DNA-templated Response To Organic Substance RNA Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of RNA Metabolic Process Regulation Of Transcription, DNA-templated RNA Metabolic Process Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Gene Expression Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Protein Sumoylation Negative Regulation Of Nucleic Acid-templated Transcription Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Regulation Of Cell Death Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Cellular Metabolic Process Gland Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Protein Modification By Small Protein Conjugation Cellular Response To Lipid Macromolecule Biosynthetic Process Cellular Response To Stimulus Regulation Of Cellular Process Nitrogen Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Biosynthetic Process Cellular Metabolic Process Cellular Response To Organic Cyclic Compound Regulation Of Cell Proliferation Regulation Of Signaling Signaling	Peptidyl-lysine Modification DNA Methylation On Cytosine Within A CG Sequence Histone H3-K27 Methylation Peptidyl-lysine Dimethylation DNA Methylation On Cytosine Negative Regulation Of Androgen Receptor Signaling Pathway Regulation Of Androgen Receptor Signaling Pathway Histone H3-K9 Methylation Synaptonemal Complex Assembly Synaptonemal Complex Organization Protein Sumoylation Histone H3-K9 Modification Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Peptidyl-amino Acid Modification Androgen Receptor Signaling Pathway Cell Cycle Process DNA Metabolic Process Synapsis Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Homologous Chromosome Segregation Nucleobase-containing Compound Metabolic Process DNA Methylation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Intracellular Steroid Hormone Receptor Signaling Pathway Cell Cycle Cellular Nitrogen Compound Metabolic Process
Tagcloud ?		293t acts alphaclass androgen ar chaperone clone27 coimmunoprecipitation colocalization coregulator cytoplasm e3 factorkappab hek hela libraries ligase modulates prefoldintype sumoylation termed transcript transducer trapped twohybrid ubiquitously uxt yeast
Tagcloud (Difference) ?		293t acts alphaclass androgen ar chaperone clone27 coimmunoprecipitation colocalization coregulator cytoplasm e3 factorkappab hek hela libraries ligase modulates prefoldintype sumoylation termed transcript transducer trapped twohybrid ubiquitously uxt yeast
Tagcloud (Intersection) ?