PIAS2 and ZNRD2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PIAS2	ZNRD2
Description		protein inhibitor of activated STAT 2	zinc ribbon domain containing 2
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm PML Body Nuclear Speck	Cytoplasm
	Molecular Function	DNA Binding Transcription Coregulator Activity Transcription Corepressor Activity Protein Binding Zinc Ion Binding Transferase Activity SUMO Transferase Activity Ubiquitin Protein Ligase Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding SUMO Ligase Activity	Protein Binding Identical Protein Binding Metal Ion Binding
	Biological Process	DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transforming Growth Factor Beta Receptor Signaling Pathway Protein Sumoylation Endoplasmic Reticulum Unfolded Protein Response Negative Regulation Of DNA-templated Transcription Regulation Of Macromolecule Metabolic Process SMAD Protein Signal Transduction Negative Regulation Of Androgen Receptor Signaling Pathway	Mitotic Cell Cycle Cell Division
Pathways		Activation of anterior HOX genes in hindbrain development during early embryogenesis
Drugs
Diseases
GWAS		Fruit consumption ( 32066663)	Glaucoma (primary open-angle) ( 33627673)
Interacting Genes		128 interacting genes: - ACY3 ADA AKT1 AR ATF2 C1QA C5orf24 CBS CCHCR1 CCNDBP1 CDCA8 CGGBP1 CHMP4B CLDN2 CREB1 CREBBP CTBP1 DDX39B DES DEUP1 DMC1 DNMT3A EDC3 ELK1 ESR1 ESR2 EXOSC8 FAM118B FKBP6 FLI1 GFAP GLUL GOLGA2 GRHL2 GRM8 GTF2I GTF2IRD1 HDAC3 HMBOX1 HMG20A HMG20B HMGXB4 HNRNPCL1 HNRNPUL1 HOMER1 HOOK1 HUWE1 IKZF1 IMPDH1 JUN KIFC3 LCE1E LCE2C LMNA LMNB1 MAPK14 MAPK8 MAPKAPK2 MBD1 MITF MLX MSX2 MX1 MX2 NAV2 NME7 NR3C1 PAICS PARK7 PAXIP1 PGR PHC1 PIAS1 PIAS4 PLAG1 PLAGL1 PML PRKAB2 PRKRA PRPH RFX2 RUFY1 RUNX1T1 SEC23A SIAH1 SIAH2 SMAD3 SMAD4 SNAI2 SNIP1 SOX5 SPATC1L SPINDOC SREBF2 STAT1 STAT4 STIP1 SUMO1 SUMO1P1 SUMO2 SUMO3 SYN3 TH TICAM2 TP53 TRAF2 TRAF3 TRAF5 TRIM23 TRIM27 TRIM50 TRIM55 TRIM63 TSR2 TXLNA UBASH3B UBE2I UBE2L3 UBQLN1 ZBED1 ZBTB16 ZBTB8A ZC3H10 ZFP42 ZNF319 ZNF451 ZNRD2	27 interacting genes: ACTN2 CATSPERT CCDC33 CCNH CCT2 CCT3 CCT5 CCT7 FNDC11 FXR2 IL16 INCA1 MYO15B NME6 NOC4L PIAS2 RNF115 RNF4 SNAPC5 STAT3 SUMO1P1 TRAF3IP3 TRAPPC6A UBC UBE2I VTA1 ZMYM5
Entrez ID		9063	10534
HPRD ID		06944	06921
Ensembl ID		ENSG00000078043	ENSG00000173465
Uniprot IDs		O75928 Q2TA77	G3V1B8 O60232
PDB IDs		2ASQ 4FO9	6HCZ
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Nucleus Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Enzyme Binding Negative Regulation Of Biosynthetic Process Negative Regulation Of DNA-templated Transcription DNA Binding Negative Regulation Of RNA Biosynthetic Process PML Body Protein Sumoylation Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nucleoplasm Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Activity Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Transcription Coactivator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Protein Binding Regulation Of Primary Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of DNA-templated Transcription DNA-binding Transcription Factor Activity, RNA Polymerase II-specific SUMO Transferase Activity Positive Regulation Of Transcription By RNA Polymerase II RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Zinc Ion Binding Positive Regulation Of Biosynthetic Process Cytoplasm Positive Regulation Of Macromolecule Metabolic Process Protein Modification By Small Protein Conjugation Ubiquitin Protein Ligase Binding Estrogen Response Element Binding Sequence-specific DNA Binding Positive Regulation Of Metabolic Process	Positive Regulation Of Telomerase RNA Localization To Cajal Body Positive Regulation Of Protein Localization To Cajal Body Chaperonin-containing T-complex Regulation Of Telomerase RNA Localization To Cajal Body Positive Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Binding Of Sperm To Zona Pellucida ATP-dependent Protein Folding Chaperone Sperm-egg Recognition Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of DNA Biosynthetic Process Regulation Of Telomere Maintenance Via Telomere Lengthening Cell-cell Recognition Protein Folding Chaperone Positive Regulation Of Telomere Maintenance Cell Body Regulation Of DNA Biosynthetic Process Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Chromosome Organization PML Body Regulation Of Telomere Maintenance Unfolded Protein Binding Protein Stabilization Regulation Of Chromosome Organization Cell Recognition Zona Pellucida Receptor Complex Protein Sumoylation Regulation Of Protein Localization To Nucleus Protein Tag Activity Regulation Of Protein Stability Protein Folding Transcription Factor Binding SUMO Transferase Activity Protein Modification By Small Protein Conjugation Positive Regulation Of DNA Metabolic Process Positive Regulation Of Organelle Organization Actin Filament Uncapping SUMO Conjugating Enzyme Activity RNA Polymerase II General Transcription Initiation Factor Activity Protein K11-linked Ubiquitination Post-translational Protein Modification Microtubule
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