PRPS1 and GORASP2

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PRPS1	GORASP2
Gene Name		phosphoribosyl pyrophosphate synthetase 1	golgi reassembly stacking protein 2, 55kDa
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Gene Ontology Annotations	Cellular Component	Cytosol	Golgi Membrane Golgi Apparatus Membrane
	Molecular Function	Magnesium Ion Binding Ribose Phosphate Diphosphokinase Activity ATP Binding Kinase Activity Protein Homodimerization Activity	Protein Binding
	Biological Process	Carbohydrate Metabolic Process 5-phosphoribose 1-diphosphate Biosynthetic Process Purine Nucleobase Metabolic Process Purine Nucleotide Biosynthetic Process Pyrimidine Nucleotide Biosynthetic Process Nervous System Development Ribonucleoside Monophosphate Biosynthetic Process Pathogenesis Phosphorylation Urate Biosynthetic Process Small Molecule Metabolic Process Hypoxanthine Biosynthetic Process	Mitotic Cell Cycle Organelle Organization
Pathways		5-Phosphoribose 1-diphosphate biosynthesis Myoclonic epilepsy of Lafora Glycogen storage diseases Metabolism of carbohydrates	Mitotic Prophase Golgi Cisternae Pericentriolar Stack Reorganization Cell Cycle, Mitotic M Phase
Drugs
Diseases
GWAS			Cognitive performance ( 19734545)
Protein-Protein Interactions		5 interactors: GORASP2 PRPS2 PRPSAP1 SPG21 SUMO4	69 interactors: AAMDC ACY3 AES APP ARL6IP1 ATXN1L BEND5 BLZF1 C1orf94 CBLB CCDC153 CDC23 CRYAA DCTD DMC1 DPYSL2 DUSP21 EIF2B1 ENOX1 GABPB2 GOLGA2 JADE2 KCTD5 KCTD9 KIFC3 LONRF1 LTBP3 MAP1LC3B MAPK1 MAPK14 MAPK8 MID2 MIF MORN2 NME1 NQO2 NUP62 ODC1 PCBD1 PDE9A PNMA5 PRDX3 PRPS1 PRRC2A PSMA3 RAB1A RAB2A RAD54B RGS3 RPIA SCAND1 SELENBP1 STOX1 TCF4 TEKT3 TGFA TMED10 TMED2 TMED3 TRAF1 TRAF2 TRAF4 TRAF5 TRIM38 TSC22D4 TXLNA ZBTB14 ZMAT1 ZNF148
Entrez ID		5631	26003
HPRD ID		02413	08303
Ensembl ID		ENSG00000147224	ENSG00000115806
Uniprot IDs		B7ZB02 P60891	B4DKT0 B4DNR1 Q9H8Y8
PDB IDs		2H06 2H07 2H08 2HCR 3EFH 3S5J 4F8E	3RLE 4EDJ
Enriched GO Terms of Interacting Partners?		5-phosphoribose 1-diphosphate Biosynthetic Process AMP Biosynthetic Process Nucleotide Biosynthetic Process	Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Protein Binding Regulation Of Binding Positive Regulation Of NF-kappaB Transcription Factor Activity Golgi Organization Regulation Of Protein Metabolic Process Regulation Of Apoptotic Process Regulation Of MAP Kinase Activity Regulation Of Cell Death Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cargo Loading Into Vesicle Regulation Of Kinase Activity Positive Regulation Of Intracellular Signal Transduction Protein Transport Positive Regulation Of Signal Transduction Regulation Of Protein Kinase Activity Establishment Of Protein Localization Intracellular Protein Transport Regulation Of Protein Homodimerization Activity Regulation Of MAPK Cascade TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Metabolic Process MyD88-independent Toll-like Receptor Signaling Pathway COPII-coated Vesicle Budding Regulation Of Nitrogen Compound Metabolic Process Toll-like Receptor 3 Signaling Pathway Establishment Of Localization In Cell Regulation Of Signal Transduction Positive Regulation Of Cell Proliferation Negative Regulation Of Cellular Metabolic Process Protein Complex Assembly Positive Regulation Of Protein Metabolic Process Protein Homooligomerization Toll-like Receptor 4 Signaling Pathway Cell Death Death Positive Regulation Of Protein Serine/threonine Kinase Activity Protein Localization Positive Regulation Of Transferase Activity Cellular Localization Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Apoptotic Process Protein Ubiquitination Intracellular Transport Negative Regulation Of Programmed Cell Death Negative Regulation Of Transferase Activity Protein Oligomerization Endomembrane System Organization Cell Cycle Cellular Protein Localization
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