PRPS1 and PRPSAP1

Number of citations of the paper that reports this interaction (PubMedID 9366267)
0

Data Source:
HPRD (in vivo, in vitro)

		PRPS1	PRPSAP1
Description		phosphoribosyl pyrophosphate synthetase 1	phosphoribosyl pyrophosphate synthetase associated protein 1
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GO Annotations	Cellular Component	Ribose Phosphate Diphosphokinase Complex Cytoplasm Cytosol	Cytoplasm
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Ribose Phosphate Diphosphokinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding	Magnesium Ion Binding Enzyme Inhibitor Activity Protein Binding Enzyme Regulator Activity Identical Protein Binding
	Biological Process	5-phosphoribose 1-diphosphate Biosynthetic Process Nucleobase-containing Compound Metabolic Process Purine Nucleobase Metabolic Process Purine Nucleotide Biosynthetic Process Pyrimidine Nucleotide Biosynthetic Process Nervous System Development Ribonucleoside Monophosphate Biosynthetic Process Nucleotide Biosynthetic Process Urate Biosynthetic Process Hypoxanthine Biosynthetic Process	5-phosphoribose 1-diphosphate Biosynthetic Process Nucleobase-containing Compound Metabolic Process Purine Nucleotide Biosynthetic Process Nucleotide Biosynthetic Process
Pathways		5-Phosphoribose 1-diphosphate biosynthesis
Drugs
Diseases		Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy Phosphoribosylpyrophosphate synthetase I superactivity Arts syndrome
GWAS			High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) High-grade serous ovarian cancer ( 31469419) Nontraumatic osteonecrosis of the femoral head ( 32701715) Red cell distribution width ( 32888494) Reticulocyte count ( 32888494) Urate levels ( 23263486)
Interacting Genes		5 interacting genes: CEBPA GORASP2 PRPSAP1 SPG21 SUMO4	8 interacting genes: CAPN7 DDX19B MAGOHB MAPK1 PLEKHF2 PRPS1 PRPS2 UBE2I
Entrez ID		5631	5635
HPRD ID		02413	03151
Ensembl ID		ENSG00000147224	ENSG00000161542
Uniprot IDs		B7ZB02 P60891	B4DP31 Q14558
PDB IDs		2H06 2H07 2H08 2HCR 3EFH 3S5J 4F8E 4LYG 4LZN 4LZO 4M0P 4M0U 8DBC 8DBD 8DBE 8DBF 8DBG 8DBH 8DBI 8DBJ 8DBK 8DBL 8DBM 8DBN 8DBO	2C4K
Enriched GO Terms of Interacting Partners?		Developmental Maturation CHOP-C/EBP Complex RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Response To Vitamin B2 White Fat Cell Proliferation C/EBP Complex Cell Maturation Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex 5-phosphoribose 1-diphosphate Biosynthetic Process SUMO Ligase Complex	Ribose Phosphate Diphosphokinase Activity 5-phosphoribose 1-diphosphate Biosynthetic Process Nuclear Export ATP Binding Ribonucleoside Monophosphate Biosynthetic Process Nucleoside Monophosphate Biosynthetic Process Nuclear Transport Nucleocytoplasmic Transport Pyrimidine-containing Compound Metabolic Process Nucleotide Binding Ribose Phosphate Diphosphokinase Complex Nucleoside Monophosphate Metabolic Process SUMO Conjugating Enzyme Activity MRNA Export From Nucleus RNA Export From Nucleus Nuclear Pore Cytosine Metabolic Process Urate Biosynthetic Process Interleukin-34-mediated Signaling Pathway Hypoxanthine Biosynthetic Process RING-like Zinc Finger Domain Binding Intracellular Transport MIT Domain Binding Exon-exon Junction Subcomplex Mago-y14 Nucleobase-containing Small Molecule Metabolic Process Caveolin-mediated Endocytosis Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Regulation Of Golgi Inheritance Positive Regulation Of Macrophage Proliferation Positive Regulation Of Locomotion Kinase Activity Hypoxanthine Metabolic Process Ribose Phosphate Biosynthetic Process SUMO Ligase Complex Small Protein Activating Enzyme Binding HLH Domain Binding RNA Transport MRNA Transport Purine Nucleotide Biosynthetic Process Cardiac Neural Crest Cell Development Involved In Heart Development Trachea Formation Cellular Localization Establishment Of Localization In Cell Outer Ear Morphogenesis ERBB3 Signaling Pathway Positive Regulation Of Peptidyl-threonine Phosphorylation RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity ERBB2-ERBB3 Signaling Pathway Bergmann Glial Cell Differentiation
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