PRPS1 and PRPSAP1

Number of citations of the paper that reports this interaction (PMID 9366267)
0

Data Source:
HPRD (in vivo, in vitro)

		PRPS1	PRPSAP1
Gene Name		phosphoribosyl pyrophosphate synthetase 1	phosphoribosyl pyrophosphate synthetase-associated protein 1
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Gene Ontology Annotations	Cellular Component	Cytosol	Ribose Phosphate Diphosphokinase Complex
	Molecular Function	Magnesium Ion Binding Ribose Phosphate Diphosphokinase Activity ATP Binding Kinase Activity Protein Homodimerization Activity	Magnesium Ion Binding Ribose Phosphate Diphosphokinase Activity Enzyme Inhibitor Activity Kinase Binding
	Biological Process	Carbohydrate Metabolic Process 5-phosphoribose 1-diphosphate Biosynthetic Process Purine Nucleobase Metabolic Process Purine Nucleotide Biosynthetic Process Pyrimidine Nucleotide Biosynthetic Process Nervous System Development Ribonucleoside Monophosphate Biosynthetic Process Pathogenesis Phosphorylation Urate Biosynthetic Process Small Molecule Metabolic Process Hypoxanthine Biosynthetic Process	Nucleobase-containing Compound Metabolic Process Nucleotide Biosynthetic Process Negative Regulation Of Kinase Activity
Pathways		5-Phosphoribose 1-diphosphate biosynthesis Myoclonic epilepsy of Lafora Glycogen storage diseases Metabolism of carbohydrates
Drugs
Diseases
GWAS			Urate levels ( 23263486)
Protein-Protein Interactions		5 interactors: GORASP2 PRPS2 PRPSAP1 SPG21 SUMO4	5 interactors: DDX19B MAPK1 PLEKHF2 PRPS1 PRPS2
Entrez ID		5631	5635
HPRD ID		02413	03151
Ensembl ID		ENSG00000147224	ENSG00000161542
Uniprot IDs		B7ZB02 P60891	Q14558
PDB IDs		2H06 2H07 2H08 2HCR 3EFH 3S5J 4F8E	2C4K
Enriched GO Terms of Interacting Partners?		5-phosphoribose 1-diphosphate Biosynthetic Process AMP Biosynthetic Process Nucleotide Biosynthetic Process	5-phosphoribose 1-diphosphate Biosynthetic Process Ribonucleoside Monophosphate Biosynthetic Process Nucleoside Monophosphate Biosynthetic Process Nucleobase-containing Small Molecule Metabolic Process MAPK Import Into Nucleus Urate Biosynthetic Process Purine Nucleotide Biosynthetic Process Ribose Phosphate Biosynthetic Process Regulation Of Golgi Inheritance Hypoxanthine Metabolic Process Hypoxanthine Biosynthetic Process Caveolin-mediated Endocytosis Cytosine Metabolic Process AMP Biosynthetic Process Nucleocytoplasmic Transport Nuclear Transport Regulation Of Golgi Organization Nucleotide Biosynthetic Process Purine Nucleotide Metabolic Process Ribose Phosphate Metabolic Process Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Protein Transport Establishment Of Protein Localization Urate Metabolic Process Regulation Of Early Endosome To Late Endosome Transport Purine Nucleobase Biosynthetic Process AMP Metabolic Process Positive Regulation Of Peptidyl-threonine Phosphorylation ERK1 And ERK2 Cascade Phosphorylation Protein Localization JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Mammary Gland Epithelial Cell Proliferation Growth Hormone Receptor Signaling Pathway Nucleotide Metabolic Process Cellular Response To Growth Hormone Stimulus Labyrinthine Layer Blood Vessel Development Response To Epidermal Growth Factor Regulation Of Cellular Response To Heat Pyrimidine Nucleobase Metabolic Process Cytoplasmic Transport Placenta Blood Vessel Development Small Molecule Metabolic Process Lipopolysaccharide-mediated Signaling Pathway B Cell Receptor Signaling Pathway Response To Growth Hormone Purine Nucleobase Metabolic Process
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