PRPS1

Description		phosphoribosyl pyrophosphate synthetase 1
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GO Annotations	Cellular Component	Ribose Phosphate Diphosphokinase Complex Cytoplasm Cytosol
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Ribose Phosphate Diphosphokinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding
	Biological Process	5-phosphoribose 1-diphosphate Biosynthetic Process Nucleobase-containing Compound Metabolic Process Purine Nucleobase Metabolic Process Purine Nucleotide Biosynthetic Process Pyrimidine Nucleotide Biosynthetic Process Nervous System Development Ribonucleoside Monophosphate Biosynthetic Process Nucleotide Biosynthetic Process Urate Biosynthetic Process Hypoxanthine Biosynthetic Process
Pathways		5-Phosphoribose 1-diphosphate biosynthesis
Drugs
Diseases		Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy Phosphoribosylpyrophosphate synthetase I superactivity Arts syndrome
GWAS
Interacting Genes		5 interacting genes: CEBPA GORASP2 PRPSAP1 SPG21 SUMO4
Entrez ID		5631
HPRD ID		02413
Ensembl ID		ENSG00000147224
Uniprot IDs		B7ZB02 P60891
PDB IDs		2H06 2H07 2H08 2HCR 3EFH 3S5J 4F8E 4LYG 4LZN 4LZO 4M0P 4M0U 8DBC 8DBD 8DBE 8DBF 8DBG 8DBH 8DBI 8DBJ 8DBK 8DBL 8DBM 8DBN 8DBO
Enriched GO Terms of Interacting Partners?		Developmental Maturation CHOP-C/EBP Complex RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Response To Vitamin B2 White Fat Cell Proliferation C/EBP Complex Cell Maturation Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex 5-phosphoribose 1-diphosphate Biosynthetic Process SUMO Ligase Complex
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