PRPS1 and SUMO4

Number of citations of the paper that reports this interaction (PubMedID 16236267)
0

Data Source:
HPRD (in vivo)

		PRPS1	SUMO4
Description		phosphoribosyl pyrophosphate synthetase 1	small ubiquitin like modifier 4
Image			No pdb structure
GO Annotations	Cellular Component	Ribose Phosphate Diphosphokinase Complex Cytoplasm Cytosol	Nucleus SUMO Ligase Complex
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Ribose Phosphate Diphosphokinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding	Protein Tag Activity Ubiquitin-like Protein Ligase Binding
	Biological Process	5-phosphoribose 1-diphosphate Biosynthetic Process Nucleobase-containing Compound Metabolic Process Purine Nucleobase Metabolic Process Purine Nucleotide Biosynthetic Process Pyrimidine Nucleotide Biosynthetic Process Nervous System Development Ribonucleoside Monophosphate Biosynthetic Process Nucleotide Biosynthetic Process Urate Biosynthetic Process Hypoxanthine Biosynthetic Process	Protein Sumoylation Cellular Response To Oxidative Stress Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of DNA Binding Negative Regulation Of DNA Binding Negative Regulation Of DNA-templated Transcription Regulation Of Protein Localization To Nucleus
Pathways		5-Phosphoribose 1-diphosphate biosynthesis
Drugs
Diseases		Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy Phosphoribosylpyrophosphate synthetase I superactivity Arts syndrome
GWAS			Dupuytren's disease ( 28886342)
Interacting Genes		5 interacting genes: CEBPA GORASP2 PRPSAP1 SPG21 SUMO4	75 interacting genes: ACADM ACO2 ACTG1 ALDOA ARHGDIA ATP5F1B CALR CAT CCT2 CCT5 CCT6A CCT7 CLIC1 DNAJA1 DNAJB11 EIF3I ENO1 ENO2 FOS G6PD GAPDH GMPS GSTP1 HNRNPD HNRNPF HNRNPH1 HNRNPL HSPA1B HSPA5 HSPA8 HSPA9 HSPD1 IDH1 IDH3A IMPDH2 JUN LDHB LMNA LMNB1 MRPS22 NFKBIA NR3C1 PA2G4 PAFAH1B3 PDIA3 PDIA6 PGK1 PHB1 PHGDH PITHD1 PPA1 PRDX2 PRDX3 PRDX4 PRDX6 PRPS1 PSMC2 RACK1 RPSA SF3B4 SPINT2 STAT1 STAT3 STIP1 STOML2 STRAP TFAP2A TOP2A TPM3 TUBA1C TXNL1 UBE2V1 VCP VDAC1 ZPR1
Entrez ID		5631	387082
HPRD ID		02413	10584
Ensembl ID		ENSG00000147224	ENSG00000177688
Uniprot IDs		B7ZB02 P60891	Q6EEV6
PDB IDs		2H06 2H07 2H08 2HCR 3EFH 3S5J 4F8E 4LYG 4LZN 4LZO 4M0P 4M0U 8DBC 8DBD 8DBE 8DBF 8DBG 8DBH 8DBI 8DBJ 8DBK 8DBL 8DBM 8DBN 8DBO
Enriched GO Terms of Interacting Partners?		Developmental Maturation CHOP-C/EBP Complex RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Response To Vitamin B2 White Fat Cell Proliferation C/EBP Complex Cell Maturation Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex 5-phosphoribose 1-diphosphate Biosynthetic Process SUMO Ligase Complex	Extracellular Exosome Protein Folding ATP-dependent Protein Folding Chaperone Unfolded Protein Binding Protein Folding Chaperone Cytoplasm Purine Nucleotide Metabolic Process Cytosol Nucleotide Metabolic Process Ubiquitin Protein Ligase Binding Ribose Phosphate Metabolic Process Regulation Of Apoptotic Process Ficolin-1-rich Granule Lumen Purine-containing Compound Metabolic Process Regulation Of Programmed Cell Death Identical Protein Binding RNA Binding Nucleoside Phosphate Metabolic Process Nicotinamide Nucleotide Metabolic Process Protein Refolding ATP Metabolic Process Secretory Granule Lumen Purine Ribonucleotide Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Peroxiredoxin Activity Ribonucleotide Metabolic Process Hydrogen Peroxide Catabolic Process Negative Regulation Of Apoptotic Process Nucleobase-containing Compound Metabolic Process Cellular Response To Cytokine Stimulus Negative Regulation Of Programmed Cell Death Positive Regulation Of Telomerase RNA Localization To Cajal Body Mitochondrion Positive Regulation Of Telomere Maintenance Via Telomerase Oxidoreductase Activity Antioxidant Activity Positive Regulation Of Protein Localization To Cajal Body Chaperonin-containing T-complex Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Ribonucleoprotein Complex Small Molecule Metabolic Process Generation Of Precursor Metabolites And Energy Response To Peptide Enzyme Binding Regulation Of Telomerase RNA Localization To Cajal Body Peroxidase Activity Nucleus Hydrogen Peroxide Metabolic Process Response To Stress Organophosphate Metabolic Process
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