MYOG and CSRP3

Number of citations of the paper that reports this interaction (PubMedID 9234731)
64

Data Source:
HPRD (in vitro, in vivo)

		MYOG	CSRP3
Description		myogenin	cysteine and glycine rich protein 3
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Protein-DNA Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Sarcomere Z Disc
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Chromatin DNA Binding Sequence-specific DNA Binding Protein Dimerization Activity E-box Binding Sequence-specific Double-stranded DNA Binding	Actin Binding Protein Binding Structural Constituent Of Muscle Telethonin Binding Identical Protein Binding Actinin Binding Metal Ion Binding
	Biological Process	Ossification Regulation Of DNA-templated Transcription Muscle Organ Development Skeletal Muscle Tissue Development Negative Regulation Of Cell Population Proliferation Tissue Development Positive Regulation Of Myotube Differentiation Positive Regulation Of Muscle Atrophy Regulation Of Skeletal Muscle Satellite Cell Proliferation Response To Muscle Activity Involved In Regulation Of Muscle Adaptation Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Striated Muscle Atrophy Response To Denervation Involved In Regulation Of Muscle Adaptation Myotube Differentiation Cell Differentiation Skeletal Muscle Cell Differentiation Muscle Cell Differentiation Muscle Cell Fate Commitment Positive Regulation Of Myoblast Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Animal Organ Development Skeletal Muscle Fiber Development Positive Regulation Of Skeletal Muscle Fiber Development Regulation Of Cell Cycle Cellular Response To Lithium Ion Cellular Response To Tumor Necrosis Factor Cellular Response To Growth Factor Stimulus Cellular Response To Estradiol Stimulus Regulation Of Myoblast Fusion	Regulation Of The Force Of Heart Contraction Cardiac Muscle Hypertrophy Intracellular Calcium Ion Homeostasis Inflammatory Response Heart Development Muscle Organ Development Skeletal Muscle Tissue Development Insulin Receptor Signaling Pathway Cell Differentiation T-tubule Organization Protein Localization To Organelle Detection Of Muscle Stretch Glucose Homeostasis Sarcomere Organization Negative Regulation Of Myoblast Differentiation Positive Regulation Of Myoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Muscle Cell Cellular Homeostasis Cardiac Muscle Tissue Development Cardiac Myofibril Assembly Cardiac Muscle Contraction Muscle Tissue Development Establishment Of Protein Localization To Organelle Phospholipase C/protein Kinase C Signal Transduction Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Actin Filament Severing Positive Regulation Of Actin Filament Severing
Pathways		Myogenesis Myogenesis TGFBR3 expression
Drugs
Diseases			Hypertrophic cardiomyopathy (HCM)
GWAS		Asthma ( 30929738 31959851) Asthma (childhood onset) ( 30929738)	Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 27863252 32888494) Mean spheric corpuscular volume ( 32888494) Mosquito bite size ( 28199695) Red blood cell count ( 27863252 32888494)
Interacting Genes		62 interacting genes: ABI2 BBS4 BFSP2 BHLHA15 CALM1 CALM2 CALM3 CARM1 CCDC120 CCDC28A CDH18 CFAP53 CFTR CLUAP1 CPSF4 CSRP3 CTNNA3 EIF4E2 FAM110A FAM90A1 FBXO32 FBXO7 FIGLA FTL GEM H2AP HNF1A ID1 ID2 ID3 IKBIP IL16 KLHL42 LAMTOR5 LMO3 MAPK3 MAPKBP1 MBD3 MDFI MEF2A MEF2C MLH1 NEK6 ODAD4 PACRGL POLR2C POLR2J PRMT5 SEPTIN5 SP1 SPG21 SRF TAF6L TCF3 TLE5 TRIM43 TSSK3 TTC32 TXNDC9 USHBP1 YME1L1 ZCCHC14	11 interacting genes: ACTN1 FHL1 HDAC4 LDHD LIMS1 MYF6 MYOD1 MYOG NHLH1 RIN3 SPTB
Entrez ID		4656	8048
HPRD ID		01167	07525
Ensembl ID		ENSG00000122180	ENSG00000129170
Uniprot IDs		P15173	A0A3B3ISZ2 A2TDB8 P50461
PDB IDs			2O10 2O13
Enriched GO Terms of Interacting Partners?		Protein Dimerization Activity Negative Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity DNA-binding Transcription Factor Binding Cytoskeleton Transporter Inhibitor Activity Regulation Of Calcium Ion Export Across Plasma Membrane Spindle Pole Protein-containing Complex BHLH Transcription Factor Binding Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Heart Development Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Negative Regulation Of High Voltage-gated Calcium Channel Activity Titin Binding Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Transcription Regulator Inhibitor Activity Spindle Microtubule Nucleus Detection Of Calcium Ion Cardiac Myofibril Assembly Regulation Of Cell Communication By Electrical Coupling Calcium Channel Regulator Activity Protein Phosphatase Activator Activity Protein Heterodimerization Activity Histone Arginine N-methyltransferase Activity Calyx Of Held Sarcomere E-box Binding Positive Regulation Of Macromolecule Biosynthetic Process Face Development Catalytic Complex Heart Looping Regulation Of Developmental Process Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Regulation Of Heart Contraction Developmental Process Embryonic Heart Tube Morphogenesis Negative Regulation Of Transporter Activity Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Calcium Channel Complex Calcineurin-mediated Signaling Positive Regulation Of Biosynthetic Process Lung Morphogenesis Regulation Of B Cell Activation Presynaptic Cytosol Regulation Of Cardiac Muscle Cell Action Potential Response To Calcium Ion Myelin Sheath	Regulation Of Myotube Differentiation Positive Regulation Of Skeletal Muscle Fiber Development Regulation Of Skeletal Muscle Fiber Development Muscle Cell Fate Commitment Positive Regulation Of Striated Muscle Tissue Development Regulation Of Striated Muscle Cell Differentiation Positive Regulation Of Skeletal Muscle Tissue Development DNA-binding Transcription Activator Activity Regulation Of Skeletal Muscle Tissue Development Muscle Organ Development Muscle Structure Development Regulation Of Muscle Cell Differentiation Regulation Of Striated Muscle Tissue Development Positive Regulation Of Striated Muscle Cell Differentiation Regulation Of Muscle Organ Development Positive Regulation Of Myoblast Differentiation Protein Dimerization Activity E-box Binding Skeletal Muscle Cell Differentiation Response To Denervation Involved In Regulation Of Muscle Adaptation Skeletal Muscle Tissue Development Response To Muscle Inactivity Cell Differentiation Regulation Of Myoblast Differentiation Positive Regulation Of Muscle Cell Differentiation Response To Inactivity Muscle Cell Development Cellular Developmental Process Striated Muscle Tissue Development Skeletal Muscle Tissue Regeneration Regulation Of Myoblast Fusion Myotube Differentiation Muscle Tissue Development DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Skeletal Muscle Fiber Development Cell Fate Commitment Myotube Cell Development RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Cellular Response To Estradiol Stimulus Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Biosynthetic Process Chromatin Sequence-specific Double-stranded DNA Binding Positive Regulation Of Biosynthetic Process Positive Regulation Of RNA Metabolic Process Tissue Regeneration Cortical Actin Cytoskeleton Negative Regulation Of Mast Cell Chemotaxis D-lactate Dehydrogenase (cytochrome) Activity
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