MYOG and CDH18

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		MYOG	CDH18
Name		myogenin	cadherin 18
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Protein-DNA Complex	Plasma Membrane Adherens Junction Membrane Catenin Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Chromatin DNA Binding Sequence-specific DNA Binding Protein Dimerization Activity E-box Binding Sequence-specific Double-stranded DNA Binding	Calcium Ion Binding Beta-catenin Binding Cadherin Binding Metal Ion Binding
	Biological Process	Ossification Regulation Of DNA-templated Transcription Muscle Organ Development Skeletal Muscle Tissue Development Negative Regulation Of Cell Population Proliferation Tissue Development Positive Regulation Of Myotube Differentiation Positive Regulation Of Muscle Atrophy Regulation Of Skeletal Muscle Satellite Cell Proliferation Response To Muscle Activity Involved In Regulation Of Muscle Adaptation Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Striated Muscle Atrophy Response To Denervation Involved In Regulation Of Muscle Adaptation Myotube Differentiation Cell Differentiation Skeletal Muscle Cell Differentiation Muscle Cell Differentiation Muscle Cell Fate Commitment Positive Regulation Of Myoblast Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Animal Organ Development Skeletal Muscle Fiber Development Positive Regulation Of Skeletal Muscle Fiber Development Regulation Of Cell Cycle Cellular Response To Lithium Ion Cellular Response To Tumor Necrosis Factor Cellular Response To Growth Factor Stimulus Cellular Response To Estradiol Stimulus Regulation Of Myoblast Fusion	Cell Morphogenesis Cell-cell Junction Assembly Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Cell Migration Adherens Junction Organization Cell-cell Adhesion Mediated By Cadherin Cell-cell Adhesion
Pathways		Myogenesis Myogenesis TGFBR3 expression	Adherens junctions interactions
GWAS		Asthma ( 30929738 31959851 ) Asthma (childhood onset) ( 30929738 )	Childhood body mass index ( 33045005 ) Depression (quantitative trait) ( 20800221 ) Diabetes (gestational) ( 31269844 ) Erectile dysfunction ( 30583798 ) Metabolic coherence (transcriptomic) ( 30852652 ) Mitochondrial DNA levels ( 25240745 ) Obesity in adult survivors of childhood cancer exposed to cranial radiation ( 25963547 ) Obstetric antiphospholipid syndrome ( 28424481 ) Resistant hypertension ( 31545351 ) Response to anti-TNF therapy in rheumatoid arthritis ( 26776603 ) Serum metabolite concentrations in chronic kidney disease ( 29545352 ) Type 2 diabetes ( 31049640 )
Interacting Genes		62 interacting genes: ABI2 BBS4 BFSP2 BHLHA15 CALM1 CALM2 CALM3 CARM1 CCDC120 CCDC28A CDH18 CFAP53 CFTR CLUAP1 CPSF4 CSRP3 CTNNA3 EIF4E2 FAM110A FAM90A1 FBXO32 FBXO7 FIGLA FTL GEM H2AP HNF1A ID1 ID2 ID3 IKBIP IL16 KLHL42 LAMTOR5 LMO3 MAPK3 MAPKBP1 MBD3 MDFI MEF2A MEF2C MLH1 NEK6 ODAD4 PACRGL POLR2C POLR2J PRMT5 SEPTIN5 SP1 SPG21 SRF TAF6L TCF3 TLE5 TRIM43 TSSK3 TTC32 TXNDC9 USHBP1 YME1L1 ZCCHC14	4 interacting genes: CDH12 CDH6 CDH9 MYOG
Entrez ID		4656	1016
HPRD ID		01167	04314
Ensembl ID		ENSG00000122180	ENSG00000145526
Uniprot IDs		P15173	D6RER2 Q13634
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Protein Dimerization Activity Negative Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity DNA-binding Transcription Factor Binding Cytoskeleton Transporter Inhibitor Activity Regulation Of Calcium Ion Export Across Plasma Membrane Spindle Pole Protein-containing Complex BHLH Transcription Factor Binding Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Heart Development Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Negative Regulation Of High Voltage-gated Calcium Channel Activity Titin Binding Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Transcription Regulator Inhibitor Activity Spindle Microtubule Nucleus Detection Of Calcium Ion Cardiac Myofibril Assembly Regulation Of Cell Communication By Electrical Coupling Calcium Channel Regulator Activity Protein Phosphatase Activator Activity Protein Heterodimerization Activity Histone Arginine N-methyltransferase Activity Calyx Of Held Sarcomere E-box Binding Positive Regulation Of Macromolecule Biosynthetic Process Face Development Catalytic Complex Heart Looping Regulation Of Developmental Process Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Regulation Of Heart Contraction Developmental Process Embryonic Heart Tube Morphogenesis Negative Regulation Of Transporter Activity Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Calcium Channel Complex Calcineurin-mediated Signaling Positive Regulation Of Biosynthetic Process Lung Morphogenesis Regulation Of B Cell Activation Presynaptic Cytosol Regulation Of Cardiac Muscle Cell Action Potential Response To Calcium Ion Myelin Sheath	Catenin Complex Cell-cell Adhesion Mediated By Cadherin Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Adherens Junction Organization Beta-catenin Binding Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Cell-cell Junction Assembly Cell-cell Junction Organization Cell Morphogenesis Adherens Junction Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Synaptic Membrane Adhesion Cell Junction Assembly Cadherin Binding Cell Junction Organization Cell-cell Adhesion Calcium Ion Binding Positive Regulation Of Muscle Atrophy Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Response To Muscle Activity Involved In Regulation Of Muscle Adaptation Cell Adhesion Cell Migration Cell Motility Response To Denervation Involved In Regulation Of Muscle Adaptation Striated Muscle Atrophy Response To Muscle Inactivity Positive Regulation Of Skeletal Muscle Fiber Development Muscle Atrophy CAMP Biosynthetic Process Adenylate Cyclase Activity Regulation Of Skeletal Muscle Fiber Development Response To Inactivity Adenylate Cyclase Binding Regulation Of Skeletal Muscle Satellite Cell Proliferation Cellular Response To Forskolin Positive Regulation Of Myotube Differentiation Muscle Cell Fate Commitment Regulation Of Skeletal Muscle Cell Proliferation Cellular Response To Lithium Ion Response To Forskolin Response To Lithium Ion Phosphorus-oxygen Lyase Activity Anatomical Structure Morphogenesis Positive Regulation Of Skeletal Muscle Tissue Development CAMP Metabolic Process Cyclic Nucleotide Biosynthetic Process Cellular Response To Lipid Positive Regulation Of Striated Muscle Tissue Development Regulation Of Myoblast Fusion Myotube Differentiation