INCA1 and CCNA1

Number of citations of the paper that reports this interaction (PMID 15159402)
12

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		INCA1	CCNA1
Gene Name		inhibitor of CDK, cyclin A1 interacting protein 1	cyclin A1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Nucleoplasm Cytosol Microtubule Cytoskeleton
	Molecular Function	Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding Cyclin Binding	Protein Binding Protein Kinase Binding
	Biological Process	Negative Regulation Of Cell Proliferation Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Apoptotic Signaling Pathway	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Mitotic Nuclear Division Male Meiosis I Spermatogenesis Regulation Of G2/M Transition Of Mitotic Cell Cycle Cell Division
Pathways			Cellular Senescence G2/M Transition Cyclin E associated events during G1/S transition Orc1 removal from chromatin Cyclin A/B1 associated events during G2/M transition G2 Phase G1/S Transition G1/S-Specific Transcription Removal of licensing factors from origins Mitotic G1-G1/S phases Switching of origins to a post-replicative state E2F mediated regulation of DNA replication DNA Damage/Telomere Stress Induced Senescence Synthesis of DNA Regulation of DNA replication Senescence-Associated Secretory Phenotype (SASP) APC/C:Cdc20 mediated degradation of mitotic proteins G0 and Early G1 Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes S Phase Regulation of APC/C activators between G1/S and early anaphase Cell Cycle, Mitotic APC/C-mediated degradation of cell cycle proteins SCF(Skp2)-mediated degradation of p27/p21 Orc1 removal from chromatin Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins Regulation of mitotic cell cycle APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint SCF(Skp2)-mediated degradation of p27/p21 Cyclin A:Cdk2-associated events at S phase entry Mitotic G2-G2/M phases
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-Protein Interactions		33 interactors: ARMC7 CABP5 CCNA1 CDC23 CDK2 CDKN2D CHCHD2 COL8A1 CTNNBIP1 DMRT3 EPHB6 FAM103A1 FHL2 FMR1 GRB2 HAUS1 NEK6 OSGIN1 PATE1 PTGER3 RBPMS SAP18 SCNM1 SEC14L4 SPG21 STAMBPL1 STK16 TRIP6 UBE2D4 UBXN2B VPS28 ZMYND19 ZNF205-AS1	34 interactors: ARID2 BRCA1 CABLES1 CDC20 CDC25A CDK1 CDK2 CDKN1A CDKN1B CKS1B CKS2 CUX1 E2F1 GNB2L1 GPS2 HIST1H1A HIST1H1B HIST1H2BA INCA1 KLHDC9 MCM4 MCM6 MYBL2 NPAT PGR PROCA1 RB1 RBL1 RBL2 RBM4 RPA1 SP1 SRC XRCC6
Entrez ID		388324	8900
HPRD ID		17150	04946
Ensembl ID		ENSG00000196388	ENSG00000133101
Uniprot IDs		Q0VD86	P78396
PDB IDs
Enriched GO Terms of Interacting Partners?		Mitotic Nuclear Division Mitotic Cell Cycle Process Regulation Of Mitotic Cell Cycle Phase Transition Cell Division Regulation Of Cell Cycle Phase Transition Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Protein K11-linked Ubiquitination G1/S Transition Of Mitotic Cell Cycle Cell Cycle Process Regulation Of Metabolic Process Regulation Of Mitotic Cell Cycle Recruitment Of MRNA Capping Enzyme To RNA Polymerase II Holoenzyme Complex Regulation Of Cellular Protein Metabolic Process Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Protein Ubiquitination Regulation Of Cell Cycle Process Cell Cycle Checkpoint Regulation Of Vascular Permeability Involved In Acute Inflammatory Response Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Metabolic Process Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Modification-dependent Protein Catabolic Process Nuclear Envelope Organization Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Acute Inflammatory Response Atrial Cardiac Muscle Cell Development Protein Targeting To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Cell Cycle Regulation Of Cell Cycle Cellular Protein Catabolic Process Gene Expression Spindle Assembly RNA Processing Positive Regulation Of DNA-dependent DNA Replication Initiation Negative Regulation Of DNA-templated Transcription, Initiation Negative Regulation Of Transcription Initiation From RNA Polymerase II Promoter Fever Generation	Cell Cycle G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Mitotic Cell Cycle Regulation Of Cell Cycle Cell Cycle Process Mitotic Cell Cycle Process Regulation Of Kinase Activity Chromosome Organization Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Organelle Organization Negative Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Cell Cycle Checkpoint Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Kinase Activity Negative Regulation Of Cellular Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Phosphorylation Negative Regulation Of Biosynthetic Process Cellular Macromolecule Biosynthetic Process Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Chromatin Organization Regulation Of Metabolic Process Macromolecule Biosynthetic Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression DNA Damage Checkpoint Positive Regulation Of Metabolic Process DNA Replication Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Gene Expression DNA Conformation Change Cell Division Mitotic Cell Cycle Checkpoint Positive Regulation Of Transcription, DNA-templated Regulation Of Protein Phosphorylation Positive Regulation Of Cell Cycle Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Cell Cycle Negative Regulation Of Transferase Activity Regulation Of Catalytic Activity Nucleobase-containing Compound Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Protein Metabolic Process
Tagcloud ?		accompanied arrest bax bcl2 birc5 ccna1 cdk2 cdkn1a deregulation entering g2 lats2 microrna mir modification namely nasopharyngeal nine npc phenotypes possibly precursor preliminary progression suppressing tp53 transfected tw01 words	asparaginase axis clustered confirming cure dexamethasone enhancement harboring hoxa infant lineage lymphoblastic meis1 mll nutlin oncogene orally recapitulate regimen regressions remission rg7112 translocations uncommon utility vincristine warrants xenograft xenografts
Tagcloud (Difference) ?		accompanied arrest bax bcl2 birc5 cdk2 cdkn1a deregulation entering g2 lats2 microrna mir modification namely nasopharyngeal nine npc phenotypes possibly precursor preliminary progression suppressing tp53 transfected tw01 words	asparaginase axis clustered confirming cure dexamethasone enhancement harboring hoxa infant lineage lymphoblastic meis1 mll nutlin oncogene orally recapitulate regimen regressions remission rg7112 translocations uncommon utility vincristine warrants xenograft xenografts
Tagcloud (Intersection) ?		ccna1