EEF1G and KARS

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		EEF1G	KARS
Gene Name		eukaryotic translation elongation factor 1 gamma	lysyl-tRNA synthetase
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol Membrane Extracellular Vesicular Exosome	Extracellular Region Nucleus Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Plasma Membrane Microtubule Cytoskeleton Aminoacyl-tRNA Synthetase Multienzyme Complex
	Molecular Function	Translation Elongation Factor Activity Protein Binding	TRNA Binding Lysine-tRNA Ligase Activity Protein Binding ATP Binding Amino Acid Binding Metal Ion Binding
	Biological Process	Translation Translational Elongation Response To Virus Gene Expression Cellular Protein Metabolic Process	TRNA Aminoacylation For Protein Translation Lysyl-tRNA Aminoacylation TRNA Processing Gene Expression Diadenosine Tetraphosphate Biosynthetic Process Viral Process
Pathways		Translation Eukaryotic Translation Elongation	Cytosolic tRNA aminoacylation tRNA Aminoacylation Mitochondrial tRNA aminoacylation
Drugs			L-Lysine
Diseases
GWAS
Protein-Protein Interactions		87 interactors: ABCC9 ADAP2 AKT1 ARF1 ARIH2 C11orf58 C1orf174 CARS CBX8 CCDC106 CCT7 CDC42 CDK2AP2 CDK5RAP2 CHFR CRELD1 CSTF2 CXCL13 DKC1 DLEU1 DRD3 ECH1 EEF1B2 EEF1D EEF1DP3 EFNA1 EGFR EID2B ENOX1 FAM195A FEN1 FOXG1 GADD45A GADD45G GET4 GSK3B GSTO1 HARS HDAC5 HLTF HMOX2 HNRNPH3 ILF2 KARS KLHL18 LARS LZTS1 MED31 MLH1 MTNR1A MVD NADK NCK2 NDRG1 NUDT21 NUDT3 NUP85 OGFOD2 PDCD5 PHACTR3 PLEKHA4 PLGRKT PSMD11 PTK2 PTPN4 PTPRS RBM6 RECQL5 RGL2 RPL4P5 RPS28 SAT1 SKIL SNAPIN SNRPD2 TNNT1 TP53I3 TRIB3 TRIM55 TRIM63 TUBB3 UCHL5 WDR33 YWHAG ZBED8 ZDHHC17 ZNF24	15 interactors: AIMP2 DARS2 EEF1D EEF1G FRS3 GAPDH GEMIN4 MAPK1 MAPK14 PAFAH1B1 PIK3R3 RPSA SLC25A6 SOD1 VIM
Entrez ID		1937	3735
HPRD ID		11745	03249
Ensembl ID		ENSG00000254772	ENSG00000065427
Uniprot IDs		P26641 Q53YD7	Q15046
PDB IDs		1PBU	3BJU 4DPG
Enriched GO Terms of Interacting Partners?		Gene Expression Cellular Nitrogen Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Nucleobase-containing Compound Metabolic Process RNA Metabolic Process Macromolecule Biosynthetic Process Cellular Metabolic Process Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cellular Macromolecule Biosynthetic Process Biosynthetic Process Positive Regulation Of Signal Transduction Cell Cycle Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Intracellular Transport Regulation Of Cell Development Chemotaxis Regulation Of Protein Kinase Activity Cell Cycle Regulation Of Endothelial Cell Migration Positive Regulation Of Mitochondrion Organization Regulation Of Kinase Activity Translation Negative Regulation Of Transferase Activity Regulation Of Neuron Differentiation Negative Regulation Of Protein Kinase Activity Negative Regulation Of Protein Phosphorylation Regulation Of Neurogenesis Positive Regulation Of Transferase Activity Regulation Of Intracellular Transport Cellular Response To Mechanical Stimulus Nervous System Development Cellular Response To Growth Factor Stimulus Negative Regulation Of Kinase Activity MRNA Polyadenylation Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Protein Binding Regulation Of Epithelial Cell Migration Regulation Of Intracellular Signal Transduction Negative Regulation Of Protein Metabolic Process MRNA 3'-end Processing Response To Growth Factor Regulation Of Signal Transduction Mitotic Cell Cycle Immune System Process Regulation Of Cell Projection Organization Response To UV-A Regulation Of Catalytic Activity	Apoptotic Process Retrograde Axon Cargo Transport Programmed Cell Death Cell Death Death Small Molecule Metabolic Process Translation Activation Of MAPK Activity Biosynthetic Process Translational Elongation Enzyme Linked Receptor Protein Signaling Pathway NcRNA Metabolic Process Platelet Activation Organelle Organization Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of MAP Kinase Activity Viral Process Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Osteoclast Differentiation Cellular Protein Metabolic Process Gliogenesis Gene Expression Axon Cargo Transport Regulation Of MAPK Cascade Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Transmission Of Nerve Impulse Cellular Metabolic Process Cellular Response To Organic Substance Activation Of Protein Kinase Activity Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Positive Regulation Of Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Mitochondrial Asparaginyl-tRNA Aminoacylation Response To Antipsychotic Drug Peptidyl-cysteine S-trans-nitrosylation P38MAPK Cascade TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of MAP Kinase Activity Positive Regulation Of Signal Transduction MyD88-independent Toll-like Receptor Signaling Pathway Response To Other Organism Toll-like Receptor 3 Signaling Pathway Regulation Of Phosphorylation MyD88-dependent Toll-like Receptor Signaling Pathway Cell Aging
Tagcloud ?		4egi antiporter antitumoral apparatus atf4 attenuation bip client consequent cyclophilin cystine eef1a eif4a favoring filters gcn2 hsp migrate nascent pores proteostasis ribavirin ribosomes sensitizes sorcin tbp7 transwell trap1 xct	aars acylating aminoacyl aminoars aminoarss bodies canonical dorsal drg functions ganglia glutaminyl horn injured lysyl nerve pharmaceutical possibility powerful primers qars root satellite sensory spinal synthetase synthetases trna typical
Tagcloud (Difference) ?		4egi antiporter antitumoral apparatus atf4 attenuation bip client consequent cyclophilin cystine eef1a eif4a favoring filters gcn2 hsp migrate nascent pores proteostasis ribavirin ribosomes sensitizes sorcin tbp7 transwell trap1 xct	aars acylating aminoacyl aminoars aminoarss bodies canonical dorsal drg functions ganglia glutaminyl horn injured lysyl nerve pharmaceutical possibility powerful primers qars root satellite sensory spinal synthetase synthetases trna typical
Tagcloud (Intersection) ?