EEF1G and MBD1

Number of citations of the paper that reports this interaction (PubMedID 21653829)
54

Data Source:
BioGRID (two hybrid)

		EEF1G	MBD1
Description		eukaryotic translation elongation factor 1 gamma	methyl-CpG binding domain protein 1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum Cytosol Membrane Extracellular Exosome	Nucleus Nucleoplasm Chromosome Nuclear Matrix Nuclear Speck
	Molecular Function	Translation Elongation Factor Activity Protein Binding Cadherin Binding	DNA Binding Protein Binding Zinc Ion Binding Methyl-CpG Binding Double-stranded Methylated DNA Binding Unmethylated CpG Binding Metal Ion Binding
	Biological Process	Translation Translational Elongation Response To Virus	Negative Regulation Of Transcription By RNA Polymerase II DNA Methylation-dependent Constitutive Heterochromatin Formation Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription
Pathways		Eukaryotic Translation Elongation Signaling by ALK fusions and activated point mutants	SUMOylation of transcription cofactors
Drugs
Diseases
GWAS		Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 28448500)	Chronic lymphocytic leukemia ( 28165464)
Interacting Genes		100 interacting genes: ABCC9 ADAP2 AKT1 ANKRD28 ARF1 ARIH2 C11orf58 C1orf174 CARS1 CBX8 CCDC106 CCT7 CDC42 CDK2AP2 CDK5RAP2 CEBPA CHFR CRELD1 CSTF2 CXCL13 DKC1 DLEU1 DLG4 DRD3 DYSF ECH1 EEF1B2 EEF1D EEF1DP3 EFNA1 EID2B EIF4ENIF1 ENOX1 FAM200C FEN1 FOXG1 GADD45A GADD45G GET4 GSK3B GSTO1 HARS1 HDAC5 HLTF HMOX2 HNRNPH3 ILF2 KARS1 KLHL18 LARS1 LINC01554 LZTS1 MBD1 MCRIP2 MED31 MLH1 MTNR1A MVD NADK NCK2 NDRG1 NUDT21 NUDT3 NUP85 OGFOD2 OGT PDCD5 PHACTR3 PLEKHA4 PLGRKT PSMD11 PTK2 PTPN4 PTPRF PTPRS RBM6 RECQL5 RGL2 RNF26 RPL4P5 RPS28 SAT1 SFRP2 SKIL SLC22A2 SNAPIN SNRPD2 SUMO2 TNNT1 TP53I3 TRIB3 TRIM55 TRIM63 TUBB3 UCHL5 USP7 WDR33 YWHAG ZDHHC17 ZNF24	47 interacting genes: APP ATF7IP ATF7IP2 ATXN1L C1QBP CBX4 CBX5 CCDC136 CHAF1A COPE DVL3 ECT2 EEF1G GRN HDAC3 HIPK3 HTT HUNK JAG2 LTBP3 LTBP4 MDFI MEGF6 NELL1 NELL2 NOTCH1 NOTCH3 OASL PIAS1 PIAS2 POMGNT1 RNF2 SETDB1 SLC25A3 SMAD1 SMAD3 SMAD5 SMAD7 SMAD9 SNAPC2 SP1 SUV39H1 TENM1 TIAM1 TNC ZNF384 ZNF512B
Entrez ID		1937	4152
HPRD ID		11745	01133
Ensembl ID		ENSG00000254772	ENSG00000141644
Uniprot IDs		P26641 Q53YD7	A0A994J7H0 A8K654 B4DI41 B4DUR3 Q9UIS9
PDB IDs		1PBU 5DQS 5JPO	1D9N 1IG4 4D4W 5W9Q 6D1T
Enriched GO Terms of Interacting Partners?		Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Translation Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Stress Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Nucleoplasm Positive Regulation Of Proteasomal Protein Catabolic Process Macromolecule Metabolic Process TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity TRNA Aminoacylation Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Neuron Projection Organization MRNA Cleavage And Polyadenylation Specificity Factor Complex TOR Signaling Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteolysis Negative Regulation Of Cell Differentiation Eukaryotic Translation Elongation Factor 1 Complex Regulation Of Cell Adhesion Mediated By Integrin Regulation Of TORC1 Signaling Regulation Of TOR Signaling Regulation Of Cellular Component Organization Response To Stress Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Kinase Binding Regulation Of Protein Catabolic Process Negative Regulation Of Catabolic Process Negative Regulation Of Developmental Process Hematopoietic Stem Cell Proliferation Protein Metabolic Process Potassium Channel Activator Activity RNA Metabolic Process Glutamatergic Synapse Negative Regulation Of Proteasomal Protein Catabolic Process PML Body Phosphatidylinositol-3,4-bisphosphate Binding Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process TORC1 Signaling Positive Regulation Of TORC1 Signaling Regulation Of Chromosome Organization Regulation Of Developmental Process Modulation Of Chemical Synaptic Transmission Protein Modification By Small Protein Conjugation	Heteromeric SMAD Protein Complex SMAD Protein Signal Transduction Negative Regulation Of Transcription By RNA Polymerase II Transforming Growth Factor Beta Receptor Signaling Pathway I-SMAD Binding SMAD Protein Complex Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Negative Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Binding Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Ossification DEAD/H-box RNA Helicase Binding Positive Regulation Of Developmental Process Transcription Corepressor Activity Kidney Epithelium Development Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of MiRNA Transcription Response To Growth Factor Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Regulation Of Gene Expression Transcription Regulator Complex Nucleus Regulation Of Cell Population Proliferation Regulation Of MiRNA Metabolic Process Ureteric Bud Development SUMO Ligase Activity Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Ossification Nucleoplasm Mesonephric Tubule Development Mesonephric Epithelium Development Epigenetic Regulation Of Gene Expression Cellular Response To Growth Factor Stimulus Positive Regulation Of Cell Differentiation Auditory Receptor Cell Fate Commitment Osteoblast Fate Commitment SUMO Transferase Activity
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