EEF1G and FEN1

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		EEF1G	FEN1
Gene Name		eukaryotic translation elongation factor 1 gamma	flap structure-specific endonuclease 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol Membrane Extracellular Vesicular Exosome	Nucleus Nucleoplasm Nucleolus Mitochondrion Plasma Membrane Membrane
	Molecular Function	Translation Elongation Factor Activity Protein Binding	Magnesium Ion Binding DNA Binding Damaged DNA Binding Double-stranded DNA Binding Endonuclease Activity RNA-DNA Hybrid Ribonuclease Activity Exonuclease Activity Protein Binding Double-stranded DNA Exodeoxyribonuclease Activity 5'-3' Exonuclease Activity 5'-flap Endonuclease Activity Manganese Ion Binding
	Biological Process	Translation Translational Elongation Response To Virus Gene Expression Cellular Protein Metabolic Process	Mitotic Cell Cycle Telomere Maintenance Via Recombination Telomere Maintenance DNA Catabolic Process, Endonucleolytic DNA Catabolic Process, Exonucleolytic DNA Replication DNA Strand Elongation Involved In DNA Replication DNA Repair Base-excision Repair Double-strand Break Repair Memory UV Protection Telomere Maintenance Via Semi-conservative Replication DNA Replication, Removal Of RNA Primer Nucleic Acid Phosphodiester Bond Hydrolysis RNA Phosphodiester Bond Hydrolysis, Endonucleolytic
Pathways		Translation Eukaryotic Translation Elongation	Base Excision Repair Chromosome Maintenance Synthesis of DNA Lagging Strand Synthesis Processive synthesis on the lagging strand Processive synthesis on the C-strand of the telomere Extension of Telomeres S Phase Telomere C-strand (Lagging Strand) Synthesis DNA strand elongation Cell Cycle, Mitotic Removal of the Flap Intermediate Telomere Maintenance Resolution of AP sites via the multiple-nucleotide patch replacement pathway Removal of DNA patch containing abasic residue Resolution of Abasic Sites (AP sites) Removal of the Flap Intermediate from the C-strand
Drugs
Diseases
GWAS			Metabolite levels ( 23378610) Oleic acid (18:1n-9) plasma levels ( 23362303) Palmitoleic acid (16:1n-7) plasma levels ( 23362303) Phospholipid levels (plasma) ( 21829377) Platelet counts ( 22139419) Stearic acid (18:0) plasma levels ( 23362303)
Protein-Protein Interactions		87 interactors: ABCC9 ADAP2 AKT1 ARF1 ARIH2 C11orf58 C1orf174 CARS CBX8 CCDC106 CCT7 CDC42 CDK2AP2 CDK5RAP2 CHFR CRELD1 CSTF2 CXCL13 DKC1 DLEU1 DRD3 ECH1 EEF1B2 EEF1D EEF1DP3 EFNA1 EGFR EID2B ENOX1 FAM195A FEN1 FOXG1 GADD45A GADD45G GET4 GSK3B GSTO1 HARS HDAC5 HLTF HMOX2 HNRNPH3 ILF2 KARS KLHL18 LARS LZTS1 MED31 MLH1 MTNR1A MVD NADK NCK2 NDRG1 NUDT21 NUDT3 NUP85 OGFOD2 PDCD5 PHACTR3 PLEKHA4 PLGRKT PSMD11 PTK2 PTPN4 PTPRS RBM6 RECQL5 RGL2 RPL4P5 RPS28 SAT1 SKIL SNAPIN SNRPD2 TNNT1 TP53I3 TRIB3 TRIM55 TRIM63 TUBB3 UCHL5 WDR33 YWHAG ZBED8 ZDHHC17 ZNF24	15 interactors: APEX1 APP ARHGDIA BLM CCNA2 CDK1 CDK2 EEF1G EP300 GSK3B HNRNPA1 PCNA RAD1 TERF1 WRN
Entrez ID		1937	2237
HPRD ID		11745	02670
Ensembl ID		ENSG00000254772	ENSG00000168496
Uniprot IDs		P26641 Q53YD7	P39748 Q6FHX6
PDB IDs		1PBU	1U7B 1UL1 3Q8K 3Q8L 3Q8M 3UVU
Enriched GO Terms of Interacting Partners?		Gene Expression Cellular Nitrogen Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Nucleobase-containing Compound Metabolic Process RNA Metabolic Process Macromolecule Biosynthetic Process Cellular Metabolic Process Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cellular Macromolecule Biosynthetic Process Biosynthetic Process Positive Regulation Of Signal Transduction Cell Cycle Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Intracellular Transport Regulation Of Cell Development Chemotaxis Regulation Of Protein Kinase Activity Cell Cycle Regulation Of Endothelial Cell Migration Positive Regulation Of Mitochondrion Organization Regulation Of Kinase Activity Translation Negative Regulation Of Transferase Activity Regulation Of Neuron Differentiation Negative Regulation Of Protein Kinase Activity Negative Regulation Of Protein Phosphorylation Regulation Of Neurogenesis Positive Regulation Of Transferase Activity Regulation Of Intracellular Transport Cellular Response To Mechanical Stimulus Nervous System Development Cellular Response To Growth Factor Stimulus Negative Regulation Of Kinase Activity MRNA Polyadenylation Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Protein Binding Regulation Of Epithelial Cell Migration Regulation Of Intracellular Signal Transduction Negative Regulation Of Protein Metabolic Process MRNA 3'-end Processing Response To Growth Factor Regulation Of Signal Transduction Mitotic Cell Cycle Immune System Process Regulation Of Cell Projection Organization Response To UV-A Regulation Of Catalytic Activity	DNA Replication Cell Cycle Process Cellular Response To DNA Damage Stimulus Cell Cycle Regulation Of Cell Cycle Telomere Maintenance Regulation Of Mitotic Cell Cycle Cellular Response To Stress Cell Cycle Checkpoint Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition G2/M Transition Of Mitotic Cell Cycle Regulation Of DNA Replication DNA Damage Checkpoint DNA Repair Mitotic Cell Cycle Checkpoint Chromosome Organization DNA Metabolic Process Mitotic Cell Cycle Process Mitotic G2 DNA Damage Checkpoint Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Regulation Of Catalytic Activity Negative Regulation Of Cell Cycle Regulation Of Cell Cycle Phase Transition Response To Inorganic Substance Regulation Of Cell Cycle Process Mitotic DNA Damage Checkpoint Mitotic DNA Integrity Checkpoint Positive Regulation Of Metabolic Process Response To Stress DNA-dependent DNA Replication Positive Regulation Of Cell Cycle Nucleobase-containing Compound Metabolic Process Positive Regulation Of Mitotic Cell Cycle Telomere Maintenance Via Telomere Lengthening Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process G2 DNA Damage Checkpoint DNA Catabolic Process, Exonucleolytic Positive Regulation Of DNA Metabolic Process Cellular Nitrogen Compound Metabolic Process Response To Stimulus Response To Oxidative Stress Developmental Process Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Cellular Response To Ionizing Radiation Regulation Of Cellular Protein Metabolic Process
Tagcloud ?		4egi antiporter antitumoral apparatus atf4 attenuation bip client consequent cyclophilin cystine eef1a eif4a favoring filters gcn2 hsp migrate nascent pores proteostasis ribavirin ribosomes sensitizes sorcin tbp7 transwell trap1 xct	alka alphaherpesvirus analogy backbone cnjb complexed contrasts crystallographic emb endonuclease helical helix hhh kinesin kraut kumar motifs nitrogens nuclease pelletier pol primer sawaya searches shutoff spt6 taq virion wilson
Tagcloud (Difference) ?		4egi antiporter antitumoral apparatus atf4 attenuation bip client consequent cyclophilin cystine eef1a eif4a favoring filters gcn2 hsp migrate nascent pores proteostasis ribavirin ribosomes sensitizes sorcin tbp7 transwell trap1 xct	alka alphaherpesvirus analogy backbone cnjb complexed contrasts crystallographic emb endonuclease helical helix hhh kinesin kraut kumar motifs nitrogens nuclease pelletier pol primer sawaya searches shutoff spt6 taq virion wilson
Tagcloud (Intersection) ?