DEPTOR and CHKA

Number of citations of the paper that reports this interaction (PMID 22017875)
35

Data Source:
BioGRID (enzymatic study)

		DEPTOR	CHKA
Gene Name		DEP domain containing MTOR-interacting protein	choline kinase alpha
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Intracellular	Cytosol
	Molecular Function	Protein Binding	Choline Kinase Activity Cholinesterase Activity Ethanolamine Kinase Activity Signal Transducer Activity ATP Binding Drug Binding Choline Binding Protein Homodimerization Activity
	Biological Process	Negative Regulation Of Protein Kinase Activity Negative Regulation Of TOR Signaling Intracellular Signal Transduction Negative Regulation Of Cell Size Regulation Of Extrinsic Apoptotic Signaling Pathway	Lipid Metabolic Process Phospholipid Metabolic Process Phosphatidylethanolamine Biosynthetic Process Phosphatidylcholine Biosynthetic Process CDP-choline Pathway Lipid Transport Signal Transduction Phosphorylation Choline Metabolic Process Small Molecule Metabolic Process Glycerophospholipid Biosynthetic Process
Pathways			Synthesis of PC Metabolism of lipids and lipoproteins Synthesis of PE Phospholipid metabolism Glycerophospholipid biosynthesis
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: APP BTRC CCDC110 CHKA FBXO25 LNX1 TRAF1	6 interactors: APP DEPTOR FCHSD2 PSEN2 RCC1 SKP2
Entrez ID		64798	1119
HPRD ID		13137	00327
Ensembl ID		ENSG00000155792	ENSG00000110721
Uniprot IDs		Q8TB45	P35790
PDB IDs			2CKO 2CKP 2CKQ 2I7Q 3F2R 3G15 3ZM9 4BR3 4DA5
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Protein Modification By Small Protein Conjugation Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury	Regulation Of Epidermal Growth Factor-activated Receptor Activity Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Signal Transduction Regulation Of Signaling Regulation Of Protein Tyrosine Kinase Activity Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Regulation Of Receptor Activity Regulation Of Protein Kinase Activity Notch Signaling Pathway Regulation Of Kinase Activity Regulation Of Protein Binding Negative Regulation Of Cellular Protein Metabolic Process Cellular Response To Cell-matrix Adhesion Synaptic Growth At Neuromuscular Junction G1/S Transition Of Mitotic Cell Cycle Regulation Of Catalytic Activity Negative Regulation Of Protein Metabolic Process Regulation Of Cell Cycle Collateral Sprouting In Absence Of Injury Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Protein Phosphorylation Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of Binding Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Mitotic Cell Cycle Phase Transition Learning Or Memory Cell Cycle Phase Transition Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Axon Choice Point Recognition Cognition Cellular Calcium Ion Homeostasis Regulation Of Phosphorylation Calcium Ion Homeostasis Negative Regulation Of Protein Phosphorylation Positive Regulation Of Ran GTPase Activity Neuron Remodeling Regulation Of Phosphorus Metabolic Process Positive Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Amyloid Precursor Protein Catabolic Process Positive Regulation Of Catalytic Activity Axon Guidance Regulation Of Cellular Amino Acid Metabolic Process Negative Regulation Of Phosphorylation Cellular Metal Ion Homeostasis Regulation Of Mitotic Cell Cycle Cellular Cation Homeostasis Forebrain Development
Tagcloud ?		construct cytoreductive cytotoxic downregulation inducible knockdown latter mimics mirna mirnas mm mtor myeloma p21 paralysis prevented raptor resulted ruled senescence sgk shrna silence silencing torc1 transfection unfolded upregulation xenograft
Tagcloud (Difference) ?		construct cytoreductive cytotoxic downregulation inducible knockdown latter mimics mirna mirnas mm mtor myeloma p21 paralysis prevented raptor resulted ruled senescence sgk shrna silence silencing torc1 transfection unfolded upregulation xenograft
Tagcloud (Intersection) ?