PRRG1 and UQCRH

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PRRG1	UQCRH
Description		proline rich and Gla domain 1	ubiquinol-cytochrome c reductase hinge protein
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Membrane	Mitochondrion Mitochondrial Inner Membrane Membrane Respiratory Chain Complex III Respiratory Chain Complex
	Molecular Function	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding	Protein Binding Quinol-cytochrome-c Reductase Activity
	Biological Process	Proteolysis Blood Coagulation	Oxidative Phosphorylation Mitochondrial Electron Transport, Ubiquinol To Cytochrome C Aerobic Respiration Cellular Respiration Proton Transmembrane Transport
Pathways			Respiratory electron transport Complex III assembly Complex III assembly
Drugs			2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol 6-Hydroxy-5-undecyl-4,7-benzothiazoledione Azoxystrobin (5S)-3-ANILINO-5-(2,4-DIFLUOROPHENYL)-5-METHYL-1,3-OXAZOLIDINE-2,4-DIONE (S)-famoxadone METHYL (2Z)-3-METHOXY-2-{2-[(E)-2-PHENYLVINYL]PHENYL}ACRYLATE 2-Nonyl-4-quinolinol 1-oxide Ubiquinone Q2
Diseases
GWAS			Body mass index ( 26426971) Hip circumference adjusted for BMI ( 34021172)
Interacting Genes		3 interacting genes: FBXO25 NEDD4L UQCRH	7 interacting genes: ARL8A ENTREP3 NDFIP1 NDFIP2 NPM1 PRRG1 RNF24
Entrez ID		5638	7388
HPRD ID		05113	15629
Ensembl ID		ENSG00000130962	ENSG00000173660
Uniprot IDs		O14668 Q8NEK6	P07919 Q567R0
PDB IDs			5XTE 5XTH 5XTI
Enriched GO Terms of Interacting Partners?		Respiratory Chain Complex III Mitochondrial Electron Transport, Ubiquinol To Cytochrome C Quinol-cytochrome-c Reductase Activity Respiratory Chain Complex Sodium Channel Inhibitor Activity Negative Regulation Of Sodium Ion Import Across Plasma Membrane Positive Regulation Of Caveolin-mediated Endocytosis Regulation Of Caveolin-mediated Endocytosis Potassium Channel Inhibitor Activity Ubiquitin-protein Transferase Activity Negative Regulation Of Potassium Ion Export Across Plasma Membrane Negative Regulation Of Sodium Ion Transmembrane Transport Negative Regulation Of Protein Localization To Cell Surface Regulation Of Potassium Ion Export Across Plasma Membrane Negative Regulation Of Sodium Ion Transport Monoatomic Cation Transmembrane Transport Oxidative Phosphorylation Inorganic Cation Transmembrane Transport Ventricular Cardiac Muscle Cell Action Potential Receptor Catabolic Process Negative Regulation Of Potassium Ion Transmembrane Transport Positive Regulation Of Dendrite Extension Protein Ubiquitination Sodium Ion Import Across Plasma Membrane Inorganic Ion Transmembrane Transport Protein Modification By Small Protein Conjugation Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Neuromuscular Junction Development Regulation Of Sodium Ion Transmembrane Transport Post-translational Protein Modification Sodium Channel Regulator Activity Regulation Of Protein Localization To Cell Surface Regulation Of Membrane Repolarization Negative Regulation Of Potassium Ion Transport Cardiac Muscle Cell Action Potential Involved In Contraction Cardiac Muscle Cell Action Potential Monoatomic Ion Transport Receptor Metabolic Process Multivesicular Body Regulation Of Membrane Depolarization Protein Monoubiquitination Regulation Of Dendrite Morphogenesis SCF Ubiquitin Ligase Complex Transmembrane Transport Receptor Internalization Negative Regulation Of Cation Transmembrane Transport Regulation Of Potassium Ion Transmembrane Transport Regulation Of Sodium Ion Transport Aerobic Electron Transport Chain	WW Domain Binding Positive Regulation Of Post-translational Protein Modification Positive Regulation Of Protein Ubiquitination Regulation Of Protein Ubiquitination Negative Regulation Of Transporter Activity Regulation Of Post-translational Protein Modification Regulation Of MRNA Stability Involved In Cellular Response To UV Regulation Of EIF2 Alpha Phosphorylation By DsRNA Positive Regulation Of Protein Modification Process Intracellular Transport Regulation Of Endoribonuclease Activity Negative Regulation Of Protein Transport Negative Regulation Of Isotype Switching To IgE Isotypes Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Regulation Of Ribonuclease Activity Cellular Localization Regulation Of Protein Modification Process Positive Regulation Of Centrosome Duplication Establishment Of Localization In Cell Membrane Golgi Membrane Negative Regulation Of Establishment Of Protein Localization Vacuolar Transport Negative Regulation Of Isotype Switching Regulation Of Endodeoxyribonuclease Activity Positive Regulation Of Protein Localization To Nucleolus Ribosomal Small Subunit Export From Nucleus Ribosomal Large Subunit Export From Nucleus Granular Component Endosome Negative Regulation Of Interleukin-4 Production Positive Regulation Of Protein Metabolic Process Negative Regulation Of Protein Localization Positive Regulation Of Canonical NF-kappaB Signal Transduction CD4-positive, Alpha-beta T Cell Proliferation Tat Protein Binding Regulation Of Protein Localization To Nucleolus Regulation Of Protein Localization Ribosomal Subunit Export From Nucleus Negative Regulation Of Centrosome Duplication Negative Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Negative Regulation Of Immunoglobulin Production Spindle Pole Centrosome Ribosomal Large Subunit Binding Endosome Membrane Alpha-beta T Cell Proliferation Regulation Of Isotype Switching To IgG Isotypes Negative Regulation Of Type 2 Immune Response
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