PPP1R8 and MELK

Number of citations of the paper that reports this interaction (PMID 16216881)
21

Data Source:
HPRD (in vitro)

		PPP1R8	MELK
Gene Name		protein phosphatase 1, regulatory subunit 8	maternal embryonic leucine zipper kinase
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Cytoplasm Nuclear Speck	Plasma Membrane Cell Cortex Membrane
	Molecular Function	DNA Binding RNA Binding Endonuclease Activity Protein Serine/threonine Phosphatase Inhibitor Activity Protein Binding Protein Phosphatase Type 1 Regulator Activity Ribonuclease E Activity	Protein Serine/threonine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Calcium Ion Binding Protein Binding ATP Binding Lipid Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated MRNA Processing RNA Catabolic Process Cell Proliferation RNA Splicing Negative Regulation Of Catalytic Activity RNA Phosphodiester Bond Hydrolysis	G2/M Transition Of Mitotic Cell Cycle Apoptotic Process Cell Proliferation Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Peptidyl-tyrosine Phosphorylation Hemopoiesis Positive Regulation Of Apoptotic Process Protein Autophosphorylation Neural Precursor Cell Proliferation
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		24 interactors: APP APPBP2 C14orf1 CDC5L CRMP1 CSNK2A1 CSNK2A2 CTNNBL1 EED FBXO25 GBP2 HDAC2 HMGA1 LYN MELK PPIL1 PPP1CA PPP1CC PRKACA RBM48 SETDB1 SF3B1 STC2 WDR77	9 interactors: CDC25B CDC5L EIF2S1 HIST1H1B LMNB1 MBP PPP1R8 SF3B1 ZNF622
Entrez ID		5511	9833
HPRD ID		04028	06119
Ensembl ID		ENSG00000117751	ENSG00000165304
Uniprot IDs		Q12972 Q6ICT4	B7Z1G6 Q14680
PDB IDs		3V4Y	4BKY 4BKZ 4BL1 4IXP
Enriched GO Terms of Interacting Partners?		Response To External Stimulus Triglyceride Catabolic Process Cellular Protein Modification Process Acylglycerol Catabolic Process MRNA Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Gene Expression MRNA Metabolic Process RNA Metabolic Process RNA Processing RNA Splicing Chemotaxis Developmental Process Multicellular Organismal Development System Development Axon Guidance Cellular Protein Metabolic Process Chromatin Organization Response To Abiotic Stimulus Circadian Regulation Of Gene Expression Metabolic Process Regulation Of Cell Cycle Phase Transition Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Cell Cycle Process Neuron Projection Development Cellular Metabolic Process Triglyceride Metabolic Process Regulation Of Platelet Aggregation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Axonogenesis Anatomical Structure Development Neutral Lipid Metabolic Process Axon Development Rhythmic Process Regulation Of Cell Cycle Cell Cycle Cellular Nitrogen Compound Metabolic Process Cell Morphogenesis Involved In Neuron Differentiation Chromatin Modification Neuron Development Entrainment Of Circadian Clock By Photoperiod Apoptotic Process Response To Light Stimulus Photoperiodism Entrainment Of Circadian Clock Programmed Cell Death Chromosome Organization	RNA Splicing MRNA Processing Positive Regulation Of Kinase Activity MRNA Metabolic Process Positive Regulation Of Transferase Activity RNA Processing Defense Response To Nematode
Tagcloud ?			axis caenorhabditis catalytic coexpressed collectively contributes driven elegans evolutionarily ezh2 foxm1 gbm glioblastoma gsc gscs inversely irradiation mitotic oncogenic phosphorylates polycomb possibility postirradiation radioresistance raise repressive serve tumorigenic turn
Tagcloud (Difference) ?			axis caenorhabditis catalytic coexpressed collectively contributes driven elegans evolutionarily ezh2 foxm1 gbm glioblastoma gsc gscs inversely irradiation mitotic oncogenic phosphorylates polycomb possibility postirradiation radioresistance raise repressive serve tumorigenic turn
Tagcloud (Intersection) ?