SYTL2 and NRXN1

Number of citations of the paper that reports this interaction (PMID 11243866)
14

Data Source:
HPRD (in vitro)

		SYTL2	NRXN1
Gene Name		synaptotagmin-like 2	neurexin 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Plasma Membrane Membrane Extrinsic Component Of Plasma Membrane Melanosome Exocytic Vesicle	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Integral Component Of Membrane Cell Junction Endocytic Vesicle Presynaptic Membrane Axonal Growth Cone
	Molecular Function	Phosphatidylserine Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Rab GTPase Binding Phosphatase Binding Neurexin Family Protein Binding	Receptor Activity Receptor Binding Calcium Channel Regulator Activity Calcium Ion Binding Protein Binding Acetylcholine Receptor Binding Metal Ion Binding Calcium-dependent Protein Binding Cell Adhesion Molecule Binding Neuroligin Family Protein Binding
	Biological Process	Intracellular Protein Transport Exocytosis Vesicle Docking Involved In Exocytosis Negative Regulation Of Phosphatase Activity Vesicle-mediated Transport Positive Regulation Of Mucus Secretion	Angiogenesis Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Neuron Cell-cell Adhesion Synaptic Transmission Neurotransmitter Secretion Axon Guidance Synapse Assembly Learning Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Cerebellar Granule Cell Differentiation Neuronal Signal Transduction Extracellular Matrix Organization Adult Behavior Social Behavior Protein Localization To Synapse Vocal Learning Establishment Of Protein Localization Neuromuscular Process Controlling Balance Negative Regulation Of Filopodium Assembly Positive Regulation Of Synapse Assembly Positive Regulation Of Synaptic Transmission, Glutamatergic Prepulse Inhibition Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Vocalization Behavior Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Protein Complex Assembly Involved In Synapse Maturation Positive Regulation Of Synapse Maturation Synaptic Vesicle Clustering Postsynaptic Membrane Assembly Presynaptic Membrane Assembly Gamma-aminobutyric Acid Receptor Clustering N-methyl-D-aspartate Receptor Clustering Gephyrin Clustering Guanylate Kinase-associated Protein Clustering Neuroligin Clustering Postsynaptic Density Protein 95 Clustering Receptor Localization To Synapse Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Regulation Of Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity Positive Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Grooming Behavior
Pathways			Non-integrin membrane-ECM interactions
Drugs
Diseases
GWAS			Longevity ( 20834067) Metabolite levels (HVA/MHPG ratio) ( 23319000) Personality dimensions ( 20691247) Temperament ( 22832960)
Protein-Protein Interactions		6 interactors: FBXO25 MTERF1 NRXN1 PPP1CA RAB27A RAB27B	28 interactors: APBA1 APBA2 ATP13A2 CASK MACF1 MLLT4 MYO16 NLGN1 NLGN2 NLGN3 NXPH1 NXPH2 NXPH3 PDZD2 RPH3A SDCBP2 SIPA1L1 SYT1 SYT13 SYT2 SYT4 SYT5 SYT6 SYT7 SYT9 SYTL1 SYTL2 SYTL3
Entrez ID		54843	9378
HPRD ID		10260	11858
Ensembl ID		ENSG00000137501	ENSG00000179915
Uniprot IDs		Q9HCH5	A4FVB9 A7E294 P58400 Q49A31 Q9ULB1
PDB IDs		3BC1	3B3Q
Enriched GO Terms of Interacting Partners?		Multivesicular Body Sorting Pathway Vesicle Localization Melanosome Transport Pigment Granule Transport Establishment Of Melanosome Localization Melanosome Localization Cellular Pigmentation Rab Protein Signal Transduction Positive Regulation Of Exocytosis Vesicle Docking Involved In Exocytosis Organelle Localization Vesicle Docking Secretion By Cell Membrane Docking Positive Regulation Of Constitutive Secretory Pathway Protein Complex Assembly Involved In Synapse Maturation Termination Of Mitochondrial Transcription Gamma-aminobutyric Acid Receptor Clustering Complement-dependent Cytotoxicity Pigmentation Secretion Regulation Of Secretion Protein Secretion Multivesicular Body Organization Guanylate Kinase-associated Protein Clustering Neuroligin Clustering Cytotoxic T Cell Degranulation Regulation Of Exocytosis Gephyrin Clustering Synaptic Vesicle Clustering Exosomal Secretion Neuronal Signal Transduction Establishment Of Vesicle Localization N-methyl-D-aspartate Receptor Clustering Vocal Learning Ras Protein Signal Transduction Negative Regulation Of Filopodium Assembly Postsynaptic Membrane Assembly Natural Killer Cell Degranulation Regulation Of Cellular Localization Synapse Maturation Regulation Of Grooming Behavior Presynaptic Membrane Assembly Postsynaptic Density Protein 95 Clustering T Cell Mediated Cytotoxicity Regulation Of Glycogen Catabolic Process Receptor Localization To Synapse Presynaptic Membrane Organization Auditory Behavior Establishment Of Organelle Localization	Secretion Exocytosis Secretion By Cell Transport Vesicle-mediated Transport Cellular Localization Establishment Of Localization In Cell Postsynaptic Membrane Assembly Presynaptic Membrane Assembly Presynaptic Membrane Organization Regulation Of Calcium Ion-dependent Exocytosis Cell-cell Signaling Regulation Of Respiratory Gaseous Exchange By Neurological System Process Positive Regulation Of Calcium Ion-dependent Exocytosis Positive Regulation Of Exocytosis Regulation Of Exocytosis Regulation Of Synaptic Transmission, Glutamatergic Neuron Cell-cell Adhesion Regulation Of Respiratory System Process Regulation Of Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity Membrane Assembly Positive Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Respiratory Gaseous Exchange Synaptic Transmission Membrane Biogenesis Terminal Button Organization Postsynaptic Membrane Organization Regulation Of Secretion Positive Regulation Of Synaptic Transmission Positive Regulation Of Synapse Assembly Positive Regulation Of Excitatory Postsynaptic Membrane Potential Positive Regulation Of Transport Positive Regulation Of Membrane Potential Regulation Of Synaptic Transmission Regulation Of Dendritic Spine Development Positive Regulation Of Secretion Regulation Of Synapse Assembly Intracellular Protein Transport Regulation Of Vesicle-mediated Transport Postsynaptic Density Protein 95 Clustering Regulation Of Excitatory Postsynaptic Membrane Potential Cellular Protein Localization Regulation Of Postsynaptic Membrane Potential Synapse Assembly Protein Transport Regulation Of Inhibitory Postsynaptic Membrane Potential Positive Regulation Of Synaptic Transmission, GABAergic Establishment Of Protein Localization Regulation Of Synapse Organization Protein Localization
Tagcloud ?			a432t a452v ankk1 arrb2 cdh13 chrna2 chrna9 dbh dnm1 drd2 eas fagerstrom gabbr2 grin3a mstcc n549s nrxn2 nrxn3 ntrk2 r480h rs139982841 rs142807401 rs34755188 rs75981117 skat tas2r38 v132l v389l wss
Tagcloud (Difference) ?			a432t a452v ankk1 arrb2 cdh13 chrna2 chrna9 dbh dnm1 drd2 eas fagerstrom gabbr2 grin3a mstcc n549s nrxn2 nrxn3 ntrk2 r480h rs139982841 rs142807401 rs34755188 rs75981117 skat tas2r38 v132l v389l wss
Tagcloud (Intersection) ?