MAT2B

Gene Name		methionine adenosyltransferase II, beta
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Gene Ontology Annotations	Cellular Component	Intracellular Nucleus Mitochondrion Cytosol Methionine Adenosyltransferase Complex Extracellular Vesicular Exosome
	Molecular Function	Enzyme Binding Methionine Adenosyltransferase Regulator Activity
	Biological Process	S-adenosylmethionine Biosynthetic Process One-carbon Metabolic Process Xenobiotic Metabolic Process Methylation Small Molecule Metabolic Process Regulation Of Catalytic Activity
Pathways		Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD) Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD) Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD) Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency) Defective UGT1A4 causes hyperbilirubinemia Metabolic disorders of biological oxidation enzymes Phase II conjugation Methylation Defective UGT1A1 causes hyperbilirubinemia Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD) Biological oxidations Defective GGT1 causes Glutathionuria (GLUTH) Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD) Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)
Drugs
Diseases
GWAS		Aging ( 22773346) Phospholipid levels (plasma) ( 21829377)
Protein-protein Interactions		6 interactors: APP FBXO25 KPNA3 KPNA4 MAT2A TRIM27
Entrez ID		27430
HPRD ID		05701
Ensembl ID		ENSG00000038274
Uniprot IDs		Q9NZL9
PDB IDs		2YDX 2YDY
Enriched GO Terms of Interacting Partners?		NLS-bearing Protein Import Into Nucleus Intracellular Transport Protein Import Into Nucleus Nuclear Import Negative Regulation Of Interleukin-2 Secretion Synaptic Growth At Neuromuscular Junction Viral Penetration Into Host Nucleus Protein Import Establishment Of Localization In Cell Collateral Sprouting In Absence Of Injury Protein Localization To Nucleus Collateral Sprouting Axon Midline Choice Point Recognition Cellular Localization S-adenosylmethionine Biosynthetic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Calcium Ion Import Axon Choice Point Recognition Nucleocytoplasmic Transport Nuclear Transport Interferon-gamma Secretion Neuron Remodeling Establishment Of Protein Localization To Organelle
Tagcloud ?		adenosyltransferase arfgap coimmunoprecipitation erk erk2 gateway git1 hepatology interacting interplay knocked mek mek1 methionine observe opposite orthotopic partner promoted proteomics pull raised recruits scaffold translated v1 v2 verified