MAT2B and KPNA4

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		MAT2B	KPNA4
Gene Name		methionine adenosyltransferase II, beta	karyopherin alpha 4 (importin alpha 3)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Intracellular Nucleus Mitochondrion Cytosol Methionine Adenosyltransferase Complex Extracellular Vesicular Exosome	Nucleoplasm Cytosol Extracellular Vesicular Exosome
	Molecular Function	Enzyme Binding Methionine Adenosyltransferase Regulator Activity	Protein Binding Protein Transporter Activity
	Biological Process	S-adenosylmethionine Biosynthetic Process One-carbon Metabolic Process Xenobiotic Metabolic Process Methylation Small Molecule Metabolic Process Regulation Of Catalytic Activity	NLS-bearing Protein Import Into Nucleus Cytokine-mediated Signaling Pathway Response To Hydrogen Peroxide
Pathways		Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD) Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD) Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD) Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency) Defective UGT1A4 causes hyperbilirubinemia Metabolic disorders of biological oxidation enzymes Phase II conjugation Methylation Defective UGT1A1 causes hyperbilirubinemia Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD) Biological oxidations Defective GGT1 causes Glutathionuria (GLUTH) Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD) Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)	ISG15 antiviral mechanism Interferon Signaling Cytokine Signaling in Immune system Antiviral mechanism by IFN-stimulated genes
Drugs
Diseases
GWAS		Aging ( 22773346) Phospholipid levels (plasma) ( 21829377)
Protein-Protein Interactions		6 interactors: APP FBXO25 KPNA3 KPNA4 MAT2A TRIM27	17 interactors: APP CDKN1B CSE1L CSNK2A1 CUL4B CYHR1 EXO1 HNRNPC KPNB1 MAT2B NUP50 PLAA RAC1 RCC1 RECQL TGM2 TP53
Entrez ID		27430	3840
HPRD ID		05701	04275
Ensembl ID		ENSG00000038274	ENSG00000186432
Uniprot IDs		Q9NZL9	O00629
PDB IDs		2YDX 2YDY
Enriched GO Terms of Interacting Partners?		NLS-bearing Protein Import Into Nucleus Intracellular Transport Protein Import Into Nucleus Nuclear Import Negative Regulation Of Interleukin-2 Secretion Synaptic Growth At Neuromuscular Junction Viral Penetration Into Host Nucleus Protein Import Establishment Of Localization In Cell Collateral Sprouting In Absence Of Injury Protein Localization To Nucleus Collateral Sprouting Axon Midline Choice Point Recognition Cellular Localization S-adenosylmethionine Biosynthetic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Calcium Ion Import Axon Choice Point Recognition Nucleocytoplasmic Transport Nuclear Transport Interferon-gamma Secretion Neuron Remodeling Establishment Of Protein Localization To Organelle	Regulation Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle Process Apoptotic Process Programmed Cell Death Cell Death Death Positive Regulation Of Cell Cycle Process Cell Cycle Cellular Response To Stimulus Regulation Of Cell Cycle Viral Process Positive Regulation Of Cell Cycle DNA Strand Renaturation Mitotic Cell Cycle Arrest Regulation Of Catalytic Activity Mitotic Cell Cycle Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Protein Metabolic Process Mitotic Cell Cycle Negative Regulation Of Mitotic Cell Cycle Phase Transition Mitotic Cell Cycle Checkpoint Response To Stimulus Protein Import Into Nucleus, Translocation Nucleobase-containing Compound Metabolic Process Cellular Response To DNA Damage Stimulus Positive Regulation Of Protein Complex Assembly Apoptotic Cell Clearance Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Organelle Organization Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Cell Surface Receptor Signaling Pathway Cell Cycle Process Cell Cycle Checkpoint DNA Metabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death DNA Repair Response To Abiotic Stimulus Regulation Of Growth Positive Regulation Of Cell Death DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Neuron Apoptotic Process
Tagcloud ?		adenosyltransferase arfgap coimmunoprecipitation erk erk2 gateway git1 hepatology interacting interplay knocked mek mek1 methionine observe opposite orthotopic partner promoted proteomics pull raised recruits scaffold translated v1 v2 verified	9k arrb1 atg14 atg4b cage1 cald1 cd9 chrna7 chrnb1 col1 expressional fn1 frap hey1 humn il10r il12 il13 il15 il27 immunochemical informational oas slc6a2 vegfc villi villous villus voluntarily
Tagcloud (Difference) ?		adenosyltransferase arfgap coimmunoprecipitation erk erk2 gateway git1 hepatology interacting interplay knocked mek mek1 methionine observe opposite orthotopic partner promoted proteomics pull raised recruits scaffold translated v1 v2 verified	9k arrb1 atg14 atg4b cage1 cald1 cd9 chrna7 chrnb1 col1 expressional fn1 frap hey1 humn il10r il12 il13 il15 il27 immunochemical informational oas slc6a2 vegfc villi villous villus voluntarily
Tagcloud (Intersection) ?