PADI4 and ANXA4

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		PADI4	ANXA4
Gene Name		peptidyl arginine deiminase, type IV	annexin A4
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Nucleus Cytoplasm Plasma Membrane Cell Surface Vesicle Membrane Nuclear Membrane Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Protein-arginine Deiminase Activity Calcium Ion Binding Protein Binding Arginine Deiminase Activity	Phospholipase Inhibitor Activity Calcium Ion Binding Calcium-dependent Phospholipid Binding Identical Protein Binding Calcium-dependent Protein Binding NF-kappaB Binding
	Biological Process	Nucleosome Assembly Chromatin Remodeling Transcription, DNA-templated Regulation Of Transcription, DNA-templated Cellular Protein Modification Process Chromatin Modification Protein Citrullination Stem Cell Maintenance Histone H3-R26 Citrullination Histone Citrullination Innate Immune Response	Regulation Of Transcription From RNA Polymerase II Promoter Signal Transduction Epithelial Cell Differentiation Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Apoptotic Process Negative Regulation Of Catalytic Activity Negative Regulation Of Interleukin-8 Secretion
Pathways
Drugs		L-Citrulline N-[(1S)-1-(AMINOCARBONYL)-4-(ETHANIMIDOYLAMINO)BUTYL]BENZAMIDE
Diseases
GWAS		Basal cell carcinoma ( 18849993) Rheumatoid arthritis ( 21452313 21505073)	Palmitoleic acid (16:1n-7) plasma levels ( 23362303)
Protein-Protein Interactions		6 interactors: ANXA4 APP FBXO25 HDAC2 HIST2H3A NPM1	7 interactors: GP2 NMT2 PADI4 POT1 SMPD1 TINF2 UCHL5
Entrez ID		23569	307
HPRD ID		05635	00112
Ensembl ID		ENSG00000159339	ENSG00000196975
Uniprot IDs		B2RBW0 Q9UM07	P09525 Q6LES2 Q6P452
PDB IDs		1WD8 1WD9 1WDA 2DEW 2DEX 2DEY 2DW5 3APM 3APN 3B1T 3B1U 4DKT	2ZOC
Enriched GO Terms of Interacting Partners?		Chromatin Silencing Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Blood Coagulation Hemostasis ATP-dependent Chromatin Remodeling Negative Regulation Of Gene Expression, Epigenetic Regulation Of Endoribonuclease Activity Regulation Of EIF2 Alpha Phosphorylation By DsRNA Regulation Of Body Fluid Levels Gene Silencing Wound Healing Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Response To Wounding Dendrite Development Synaptic Growth At Neuromuscular Junction Negative Regulation Of Catalytic Activity Collateral Sprouting In Absence Of Injury Maintenance Of Chromatin Silencing Regulation Of Ribonuclease Activity Regulation Of Endodeoxyribonuclease Activity Negative Regulation Of Cellular Metabolic Process Chromatin Remodeling Negative Regulation Of Neuron Differentiation Negative Regulation Of Interleukin-8 Secretion Regulation Of Transcription, DNA-templated Negative Regulation Of Apoptotic Process Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Programmed Cell Death Regulation Of RNA Biosynthetic Process Regulation Of Cell Cycle Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Gene Expression, Epigenetic Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of RNA Metabolic Process Negative Regulation Of Cell Death Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Negative Regulation Of MHC Class II Biosynthetic Process Axon Choice Point Recognition Fungiform Papilla Formation Negative Regulation Of Cardiac Muscle Cell Proliferation Regulation Of Gene Expression Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Translation Regulation Of Nitrogen Compound Metabolic Process Regulation Of Developmental Growth Negative Regulation Of Neurogenesis Positive Regulation Of Proteolysis Fungiform Papilla Morphogenesis	Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Assembly Negative Regulation Of Telomere Maintenance Positive Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Replication Telomere Maintenance Negative Regulation Of Chromosome Organization Negative Regulation Of Protein ADP-ribosylation Positive Regulation Of DNA Strand Elongation Antigen Transcytosis By M Cells In Mucosal-associated Lymphoid Tissue Negative Regulation Of DNA Metabolic Process Regulation Of Protein ADP-ribosylation N-terminal Peptidyl-glycine N-myristoylation Histone Citrullination Histone H3-R26 Citrullination Regulation Of DNA Replication Positive Regulation Of DNA Metabolic Process Telomere Formation Via Telomerase Negative Regulation Of Protein Glycosylation Negative Regulation Of Catalytic Activity Negative Regulation Of Cellular Protein Metabolic Process Protein Citrullination Regulation Of Chromosome Organization Negative Regulation Of Protein Metabolic Process Telomere Capping Protein Localization To Chromosome, Telomeric Region Positive Regulation Of Helicase Activity Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Telomerase Activity Positive Regulation Of Telomere Maintenance Via Telomerase Sphingomyelin Catabolic Process Citrulline Biosynthetic Process Chromosome Organization DNA Metabolic Process N-terminal Protein Myristoylation DNA Conformation Change Regulation Of Protein Glycosylation Negative Regulation Of Telomerase Activity Telomere Maintenance Via Telomerase Protein Myristoylation Citrulline Metabolic Process Viral Protein Processing Negative Regulation Of Transferase Activity Transcytosis Negative Regulation Of Glycoprotein Metabolic Process Sphingomyelin Metabolic Process Regulation Of Telomerase Activity
Tagcloud ?		arginine barr carm1 centre compelling continuing deiminase dissect ebv epstein gc germinal hl hodgkin latent lmp1 lymphomagenesis methyltransferases modulated next precursors presumptive prmt prmt1 prmt5 reed stably sternberg transforming	anxa2 calbindin1 cascades categorized cofilin1 cytoskeleton ddah2 differentially dj e40 e70 e93 electrophoresis elucidated embryonic expressional fetoprotein functionally grp75 kidney kidneys pig proteomic representative serves sod2 subjected tandem vil1
Tagcloud (Difference) ?		arginine barr carm1 centre compelling continuing deiminase dissect ebv epstein gc germinal hl hodgkin latent lmp1 lymphomagenesis methyltransferases modulated next precursors presumptive prmt prmt1 prmt5 reed stably sternberg transforming	anxa2 calbindin1 cascades categorized cofilin1 cytoskeleton ddah2 differentially dj e40 e70 e93 electrophoresis elucidated embryonic expressional fetoprotein functionally grp75 kidney kidneys pig proteomic representative serves sod2 subjected tandem vil1
Tagcloud (Intersection) ?