PADI4

Gene Name		peptidyl arginine deiminase, type IV
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Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm
	Molecular Function	Protein-arginine Deiminase Activity Calcium Ion Binding Protein Binding Arginine Deiminase Activity
	Biological Process	Nucleosome Assembly Chromatin Remodeling Transcription, DNA-templated Regulation Of Transcription, DNA-templated Cellular Protein Modification Process Chromatin Modification Protein Citrullination Stem Cell Maintenance Histone H3-R26 Citrullination Histone Citrullination Innate Immune Response
Pathways
Drugs		L-Citrulline N-[(1S)-1-(AMINOCARBONYL)-4-(ETHANIMIDOYLAMINO)BUTYL]BENZAMIDE
Diseases
GWAS		Basal cell carcinoma ( 18849993) Rheumatoid arthritis ( 21452313 21505073)
Protein-protein Interactions		6 interactors: ANXA4 APP FBXO25 HDAC2 HIST2H3A NPM1
Entrez ID		23569
HPRD ID		05635
Ensembl ID		ENSG00000159339
Uniprot IDs		B2RBW0 Q9UM07
PDB IDs		1WD8 1WD9 1WDA 2DEW 2DEX 2DEY 2DW5 3APM 3APN 3B1T 3B1U 4DKT
Enriched GO Terms of Interacting Partners?		Chromatin Silencing Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Blood Coagulation Hemostasis ATP-dependent Chromatin Remodeling Negative Regulation Of Gene Expression, Epigenetic Regulation Of Endoribonuclease Activity Regulation Of EIF2 Alpha Phosphorylation By DsRNA Regulation Of Body Fluid Levels Gene Silencing Wound Healing Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Response To Wounding Dendrite Development Synaptic Growth At Neuromuscular Junction Negative Regulation Of Catalytic Activity Collateral Sprouting In Absence Of Injury Maintenance Of Chromatin Silencing Regulation Of Ribonuclease Activity Regulation Of Endodeoxyribonuclease Activity Negative Regulation Of Cellular Metabolic Process Chromatin Remodeling Negative Regulation Of Neuron Differentiation Negative Regulation Of Interleukin-8 Secretion Regulation Of Transcription, DNA-templated Negative Regulation Of Apoptotic Process Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Programmed Cell Death Regulation Of RNA Biosynthetic Process Regulation Of Cell Cycle Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Gene Expression, Epigenetic Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of RNA Metabolic Process Negative Regulation Of Cell Death Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Negative Regulation Of MHC Class II Biosynthetic Process Axon Choice Point Recognition Fungiform Papilla Formation Negative Regulation Of Cardiac Muscle Cell Proliferation Regulation Of Gene Expression Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Translation Regulation Of Nitrogen Compound Metabolic Process Regulation Of Developmental Growth Negative Regulation Of Neurogenesis Positive Regulation Of Proteolysis Fungiform Papilla Morphogenesis
Tagcloud ?		arginine barr carm1 centre compelling continuing deiminase dissect ebv epstein gc germinal hl hodgkin latent lmp1 lymphomagenesis methyltransferases modulated next precursors presumptive prmt prmt1 prmt5 reed stably sternberg transforming