DNAJC8 and FBXO25

Number of citations of the paper that reports this interaction (PMID 23940030)
0

Data Source:
BioGRID (enzymatic study)

		DNAJC8	FBXO25
Gene Name		DnaJ (Hsp40) homolog, subfamily C, member 8	F-box protein 25
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm	Ubiquitin Ligase Complex Nucleus Nucleolus SCF Ubiquitin Ligase Complex
	Molecular Function		Actin Binding Ubiquitin-protein Transferase Activity Protein Binding
	Biological Process	MRNA Splicing, Via Spliceosome RNA Splicing Gene Expression	Protein Ubiquitination
Pathways		Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS
Protein-Protein Interactions		6 interactors: APP FBXO25 HMGA1 IKBKG SRPK1 SRPK2	80 interactors: ADRBK1 ANKRD13A APLF AXL BMX C11orf63 C19orf57 C6orf106 C7orf50 CDK5RAP2 CDK9 CENPB CUL1 CXXC4 DCX DDX42 DEPTOR DNAJB2 DNAJC8 DYRK3 DYRK4 EGFR EID3 EIF4E2 ELK1 EPN1 FKBP3 G3BP1 GTF2B GTF2IRD2 HIP1 HMCES HP1BP3 IL21 ING3 IRS1 KDR KRT8 LMCD1 LUC7L MAT2B NSRP1 NUAK1 ODF2 ORC4 PADI4 PAK4 PCK1 PDGFRA PIP4K2C PPID PPP1R8 PRKCA PRKG2 PRR15 PRRG1 PSMD4 RABEP2 RBM8A RHBDD1 RIOK3 RPAP3 RPS10 RPS6KB2 SAMHD1 SERBP1 SKP1 STAC SYTL2 TCEAL2 TCEANC TCP10L TMA7 TNIP2 TRUB1 TWF1 UBE2D3 UBQLN1 UBQLN2 WDSUB1
Entrez ID		22826	26260
HPRD ID		13236	16439
Ensembl ID		ENSG00000126698	ENSG00000147364
Uniprot IDs		O75937	Q8TCJ0
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Viral Genome Replication Innate Immune Response Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Negative Regulation Of Viral Genome Replication MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome Immune Response Regulation Of Viral Genome Replication Positive Regulation Of Viral Process Defense Response Negative Regulation Of Viral Process Regulation Of MRNA Processing MRNA Metabolic Process Viral Process Positive Regulation Of Gene Expression RNA Metabolic Process Nuclear Speck Organization RNA Processing Regulation Of RNA Splicing Response To Stress Gene Expression Nucleus Organization Oncogene-induced Cell Senescence Synaptic Growth At Neuromuscular Junction Phosphorylation Regulation Of Viral Process Collateral Sprouting In Absence Of Injury Senescence-associated Heterochromatin Focus Assembly DNA Packaging Immune System Process Positive Regulation Of Cellular Senescence Intracellular Receptor Signaling Pathway Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Negative Regulation Of Chromatin Silencing Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Response To Virus Establishment Of Integrated Proviral Latency Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process DNA Conformation Change Positive Regulation Of Cell Aging Positive Regulation Of Cell Cycle Cellular Nitrogen Compound Metabolic Process Regulation Of Neuron Death	Regulation Of Metabolic Process Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Peptidyl-amino Acid Modification Cellular Metabolic Process Cellular Protein Modification Process Enzyme Linked Receptor Protein Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Response To Stress Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Innate Immune Response Neurotrophin Signaling Pathway Viral Process Protein Phosphorylation Cellular Response To Stimulus Cellular Response To Growth Factor Stimulus Fibroblast Growth Factor Receptor Signaling Pathway Cellular Protein Metabolic Process Response To Growth Factor Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Gene Expression Peptidyl-tyrosine Phosphorylation Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Positive Regulation Of Phospholipase C Activity Phosphorylation Intracellular Signal Transduction Regulation Of Cellular Process Rhythmic Process Protein Autophosphorylation Positive Regulation Of Phospholipase Activity Response To Stimulus Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Response To Organic Substance Immune Response Proteasomal Protein Catabolic Process G1/S Transition Of Mitotic Cell Cycle Response To UV-A Peptidyl-serine Autophosphorylation Regulation Of Phospholipase Activity Apoptotic Process Positive Regulation Of Lipase Activity Defense Response Protein Metabolic Process Regulation Of Cell Death Immune System Process Programmed Cell Death Regulation Of Cellular Protein Metabolic Process Cellular Macromolecule Catabolic Process
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