DNAJC8 and RPL34

Number of citations of the paper that reports this interaction (PubMedID 34133714)
84

Data Source:
BioGRID (proximity labelling technology, two hybrid)

		DNAJC8	RPL34
Description		DnaJ heat shock protein family (Hsp40) member C8	ribosomal protein L34
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Intercellular Bridge	Nucleolus Cytoplasm Endoplasmic Reticulum Cytosol Ribosome Cytosolic Large Ribosomal Subunit Cytosolic Ribosome Synapse Extracellular Exosome Ribonucleoprotein Complex
	Molecular Function	Protein Binding Hsp70 Protein Binding	RNA Binding Structural Constituent Of Ribosome Protein Binding Cadherin Binding
	Biological Process		Cytoplasmic Translation Translation
Pathways		mRNA Splicing - Major Pathway	L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Drugs
Diseases
GWAS		Aspartate aminotransferase levels ( 33547301) Hematocrit ( 32888494)	Apolipoprotein A1 levels ( 32203549) Blond vs. brown/black hair color ( 30531825) Height ( 25282103)
Interacting Genes		9 interacting genes: AGTR1 APP CEBPA FBXO25 HMGA1 IKBKG RPL34 SRPK1 SRPK2	10 interacting genes: APP CDK4 CDK5 DAPK3 DDX21 DNAJC8 FNDC3B MAX PTEN SRPK2
Entrez ID		22826	6164
HPRD ID		13236	17996
Ensembl ID		ENSG00000126698	ENSG00000109475
Uniprot IDs		O75937	P49207
PDB IDs		7VPX	4UG0 4V6X 5AJ0 5LKS 5T2C 6IP5 6IP6 6IP8 6LQM 6LSR 6LSS 6LU8 6MTD 6MTE 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6W6L 6XA1 6Y0G 6Y2L 6Y57 6Y6X 6Z6L 6Z6M 6Z6N 6ZM7 6ZME 6ZMI 6ZMO 7BHP 7F5S 7OW7 7XNX 7XNY 8A3D 8FKY 8FKZ 8FL2 8FL3 8FL4 8FL6 8FL7 8FL9 8FLA 8FLB 8FLC 8FLD 8FLE 8FLF 8G5Y 8G5Z 8G60 8G61 8G6J 8GLP 8IDT 8IDY 8IE3 8IFD 8IFE 8INE 8INF 8INK 8IPD 8IPX 8IPY 8IR1 8IR3 8JDJ 8JDK 8JDL 8JDM 8K2C 8OHD 8OJ0 8OJ5 8OJ8 8QFD 8QOI 8QYX 8RL2 8UKB 8XSX 8XSY 8XSZ 8Y0W 8Y0X 8YOO 8YOP 9C3H 9G8M 9GMO
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Defense Response Protein-containing Complex Organization Protein Heterodimerization Activity Intracellular Signaling Cassette Positive Regulation Of Inflammatory Response Molecular Function Activator Activity Positive Regulation Of Viral Genome Replication Positive Regulation Of Proteolysis Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Response To Stress Innate Immune Response Spliceosomal Complex Assembly Negative Regulation Of Viral Genome Replication Positive Regulation Of Reactive Oxygen Species Metabolic Process Angiotensin Type I Receptor Activity Amyloid-beta Complex Growth Cone Lamellipodium Defense Response To Symbiont Regulation Of Response To Calcium Ion Defense Response To Other Organism Amylin Binding Positive Regulation Of Toll Signaling Pathway RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Viral Process Chromatin Organization Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of Viral Process Regulation Of Viral Genome Replication Regulation Of Cell Population Proliferation Signal Transduction Regulation Of Inflammatory Response Phospholipase C-activating Angiotensin-activated Signaling Pathway Bradykinin Receptor Binding Positive Regulation Of Defense Response Renin-angiotensin Regulation Of Aldosterone Production Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Proteolysis Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Regulation Of Response To Endoplasmic Reticulum Stress Lipoprotein Particle Notch Signaling Pathway Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development	Acetylcholine Receptor Activator Activity Positive Regulation Of Neuron Apoptotic Process Regulation Of Cell Cycle R-loop Processing Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Regulation Of RNA Metabolic Process Adult Behavior Axonogenesis Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Excitatory Postsynaptic Potential Regulation Of Mitotic Cell Cycle Reproductive Behavior Protein Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Amyloid-beta Complex Regulation Of Cell Junction Assembly Cell Projection Morphogenesis Presynapse Growth Cone Lamellipodium Neuron Projection Organization Regulation Of Neuron Apoptotic Process Visual Behavior Regulation Of Response To Calcium Ion Regulation Of DNA-templated Transcription Learning Or Memory Amylin Binding Neuron Projection Morphogenesis Regulation Of RNA Biosynthetic Process Response To Amyloid-beta Positive Regulation Of Toll Signaling Pathway Visual Learning Cellular Response To Amyloid-beta Modulation Of Excitatory Postsynaptic Potential Synapse Organization Nucleoplasm Regulation Of Cell Cycle Process Kinase Activity Cyclin-dependent Protein Kinase Holoenzyme Complex Negative Regulation Of Axonogenesis Negative Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Positive Regulation Of Presynaptic Cytosolic Calcium Concentration Regulation Of Myosin II Filament Organization Negative Regulation Of Synaptic Vesicle Clustering Cognition Chemical Synaptic Transmission Regulation Of Developmental Growth Glial Cell Development
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