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APPL2 and CRADD
Number of citations of the paper that reports this interaction (PubMedID
25416956
)
56
Data Source:
BioGRID
(two hybrid)
APPL2
CRADD
Description
adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2
CARD and death domain containing adaptor protein
Image
GO Annotations
Cellular Component
Ruffle
Nucleus
Cytoplasm
Endosome
Plasma Membrane
Endosome Membrane
Membrane
Cytoplasmic Vesicle Membrane
Phagocytic Vesicle Membrane
Cytoplasmic Vesicle
Early Endosome Membrane
Vesicle
Early Phagosome
Ruffle Membrane
Early Phagosome Membrane
Cell Projection
Macropinosome
Phagocytic Vesicle
Extracellular Exosome
Bounding Membrane Of Organelle
Nucleus
Nucleolus
Cytoplasm
Cytosol
Endopeptidase Complex
Molecular Function
Phosphatidylserine Binding
Protein Binding
Phosphatidylinositol Binding
Identical Protein Binding
Protein Homodimerization Activity
Protein-containing Complex Binding
Protease Binding
Protein Binding
Protein-macromolecule Adaptor Activity
Death Domain Binding
Biological Process
Diet Induced Thermogenesis
Protein Import Into Nucleus
Signal Transduction
Transforming Growth Factor Beta Receptor Signaling Pathway
Cold Acclimation
Regulation Of Fibroblast Migration
Signaling
Adiponectin-activated Signaling Pathway
Regulation Of Toll-like Receptor 4 Signaling Pathway
Cellular Response To Hepatocyte Growth Factor Stimulus
Homeostatic Process
Glucose Homeostasis
Regulation Of Innate Immune Response
Negative Regulation Of Fatty Acid Oxidation
Negative Regulation Of D-glucose Import
Negative Regulation Of Neurogenesis
Protein Homotetramerization
Positive Regulation Of Phagocytosis, Engulfment
Positive Regulation Of Cold-induced Thermogenesis
Negative Regulation Of Cytokine Production Involved In Inflammatory Response
Negative Regulation Of Cellular Response To Insulin Stimulus
Positive Regulation Of Macropinocytosis
Positive Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of Neural Precursor Cell Proliferation
Apoptotic Process
DNA Damage Response
Signal Transduction
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
DNA Damage Response, Signal Transduction By P53 Class Mediator
Regulation Of Apoptotic Process
Positive Regulation Of Apoptotic Process
Cellular Response To Mechanical Stimulus
Apoptotic Signaling Pathway
Positive Regulation Of Apoptotic Signaling Pathway
Pathways
TP53 Regulates Transcription of Caspase Activators and Caspases
Drugs
Diseases
GWAS
Mosquito bite size (
28199695
)
Alzheimer's disease (cognitive decline) (
23535033
)
Appendicular lean mass (
33097823
)
Asthma (
31959851
)
Gut microbiota (bacterial taxa, hurdle binary method) (
32572223
)
Heel bone mineral density (
28869591
30598549
)
Height (
31562340
33713608
18391951
31217584
28552196
25282103
)
High light scatter reticulocyte count (
32888494
)
High light scatter reticulocyte percentage of red cells (
32888494
)
Hip circumference adjusted for BMI (
25673412
34021172
)
Lung function (FVC) (
30804560
30061609
)
Pulse pressure (
27841878
)
Response to cognitive-behavioural therapy in anxiety disorder (
31123309
)
Reticulocyte count (
32888494
)
Waist circumference adjusted for body mass index (
34021172
)
Waist-hip index (
34021172
)
Waist-to-hip ratio adjusted for BMI (
34021172
)
Interacting Genes
31 interacting genes:
APPL1
ATF3
CNMD
CRADD
CRBN
CRLF3
CRYAA
DOK3
EPM2AIP1
HUNK
KIFC3
KMT2C
LDHAL6B
LGALS9C
LINC02875
LIX1
MLST8
MTA2
PINK1
POT1
PRR35
RAB22A
RAB5A
RAB5C
RAI2
RBBP7
RBP7
RUVBL2
SUV39H2
TINF2
TSC1
22 interacting genes:
ACTN2
APP
APPL2
BBS5
CASP2
CASP8
CCSER2
DCXR
EEF1A1
ERG28
IL9R
KCTD9
KPNA1
LRIF1
PIDD1
PTGER4
RIPK1
SLC35A3
TRIM54
TSHR
VTN
WIF1
Entrez ID
55198
8738
HPRD ID
06945
04584
Ensembl ID
ENSG00000136044
ENSG00000169372
Uniprot IDs
Q8NEU8
B4DJT6
F5H7C2
F8VV49
F8VVY5
P78560
Q53XL1
Q8IY43
PDB IDs
4H8S
5C5B
2O71
2OF5
3CRD
Enriched GO Terms of Interacting Partners
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Telomere Assembly
Regulation Of Cellular Component Organization
Response To Oxygen Levels
Response To Decreased Oxygen Levels
Plasma Membrane To Endosome Transport
GDP Binding
Early Phagosome
NuRD Complex
Chromosome, Telomeric Region
Cellular Response To Decreased Oxygen Levels
Cellular Response To Oxygen Levels
Positive Regulation Of Telomere Maintenance
Regulation Of DNA Strand Elongation
Nuclear Telomere Cap Complex
Shelterin Complex
Telomere Capping
Protein Kinase B Binding
TORC2 Signaling
Protein Binding
Regulation Of Vesicle Size
Phagocytic Vesicle
TOR Signaling
Negative Regulation Of Telomere Maintenance Via Telomerase
Regulation Of Cell Fate Specification
Positive Regulation Of Cellular Component Organization
Telomere Maintenance
Protein Stabilization
Ruffle
Negative Regulation Of Autophagy
Positive Regulation Of Chromosome Organization
Regulation Of Telomere Maintenance
Regulation Of Cellular Component Size
Telomeric DNA Binding
Negative Regulation Of Telomere Maintenance Via Telomere Lengthening
Endomembrane System
Negative Regulation Of DNA Biosynthetic Process
Positive Regulation Of TRAIL-activated Apoptotic Signaling Pathway
Memory T Cell Differentiation
Protein Folding Chaperone Complex
Epigenetic Programming Of Gene Expression
Telomere Organization
Positive Regulation Of DNA Strand Elongation
Positive Regulation Of Telomeric D-loop Disassembly
G-rich Single-stranded DNA Binding
Negative Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Regulation Of Generation Of Precursor Metabolites And Energy
Histone Methyltransferase Activity
Positive Regulation Of Biosynthetic Process
Response To Hypoxia
Negative Regulation Of Macroautophagy
Positive Regulation Of Neuron Apoptotic Process
Death Receptor Binding
Endopeptidase Complex
Extrinsic Apoptotic Signaling Pathway
Signal Transduction
Identical Protein Binding
Ripoptosome
Death-inducing Signaling Complex
Positive Regulation Of Inflammatory Response
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Response To Mechanical Stimulus
Cellular Response To Mechanical Stimulus
Positive Regulation Of Macrophage Differentiation
Negative Regulation Of Necroptotic Process
Regulation Of Neuron Apoptotic Process
Positive Regulation Of Execution Phase Of Apoptosis
Negative Regulation Of Programmed Necrotic Cell Death
Cellular Response To Growth Factor Stimulus
Execution Phase Of Apoptosis
Regulation Of Macrophage Differentiation
Positive Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Response To Growth Factor
Regulation Of Reactive Oxygen Species Metabolic Process
Amyloid Fibril Formation
Apoptotic Signaling Pathway
Regulation Of Necroptotic Process
Integrin Binding
Actin Filament Uncapping
Amyloid-beta Complex
Growth Cone Lamellipodium
Regulation Of Response To Calcium Ion
Amylin Binding
Positive Regulation Of Toll Signaling Pathway
Positive Regulation Of Apoptotic Signaling Pathway
Positive Regulation Of Endocytosis
Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway
Protein-containing Complex Binding
Regulation Of Programmed Necrotic Cell Death
Interleukin-9 Binding
Interleukin-9 Receptor Activity
Negative Regulation Of Eosinophil Extravasation
Cellular Response To Thyrotropin-releasing Hormone
Symbiont-containing Vacuole
L-xylulose Reductase (NADPH) Activity
Positive Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Regulation Of Supramolecular Fiber Organization
Regulation Of Apoptotic Process
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
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