APPL2 and TINF2

Number of citations of the paper that reports this interaction (PMID 21044950)
9

Data Source:
BioGRID (two hybrid)

		APPL2	TINF2
Gene Name		adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2	TERF1 (TRF1)-interacting nuclear factor 2
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Endosome Membrane NuRD Complex Early Endosome Membrane Extracellular Vesicular Exosome	Chromosome, Telomeric Region Nuclear Telomere Cap Complex Nucleus Nucleoplasm Perinucleolar Chromocenter Nuclear Matrix
	Molecular Function	Protein Binding	DNA Binding Protein Binding Telomeric DNA Binding
	Biological Process	Cell Cycle Signal Transduction Cell Proliferation	Telomere Maintenance Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Protein ADP-ribosylation Telomere Assembly Positive Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Via Telomerase Protein Localization To Chromosome Negative Regulation Of Epithelial Cell Proliferation Protein Localization To Chromosome, Telomeric Region
Pathways			Telomere Maintenance Packaging Of Telomere Ends DNA Damage/Telomere Stress Induced Senescence Chromosome Maintenance Cellular Senescence Meiotic synapsis
Drugs
Diseases
GWAS
Protein-Protein Interactions		11 interactors: APPL1 CRADD MTA2 POT1 RAB22A RAB5A RAB5C RBBP7 RUVBL2 SUV39H2 TINF2	88 interactors: ACD ACOT7 ACTB ADA AFAP1L2 AIPL1 AK1 ANKMY2 ANXA4 ANXA5 APOBEC3F APPL2 ARHGDIA ARID3B BAG3 BIN2 CALD1 CCDC43 CCDC9 CKB CLK3 CPNE3 CRYGS CTTN DBN1 DCX DHFRL1 DPP3 EEF1D EIF4B ENO2 FAM131B FERMT3 FKBP6 GAPDH GNMT HNMT HOXA3 HSP90AB1 IPO5 KCTD17 LASP1 LDHA LGALSL LTA4H MAP2K3 NCDN NOL3 NUDC NUDCD2 OR2H1 PAGE2 PAK1IP1 PEX5 PFKP PGM1 PGM2 PHPT1 PKM POT1 PPP1R2 PPP6R3 PRKCB REM2 RGS14 RPSA SARS SCRN2 SIAH2 STUB1 SULT1C2 TAGLN TBL1X TERF1 TERF2 TOMM34 TPP1 TRIM15 TRIM16 TRIP10 TUBB TUBB4B TXNDC17 UCHL1 VIPR1 YWHAG ZFP36L1 ZNF790
Entrez ID		55198	26277
HPRD ID		06945	16056
Ensembl ID		ENSG00000136044	ENSG00000092330
Uniprot IDs		Q8NEU8	B4DFJ1 Q9BSI4
PDB IDs		4H8S	3BQO 3BU8
Enriched GO Terms of Interacting Partners?		Chromatin Remodeling Chromosome Organization Rab Protein Signal Transduction Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Assembly Regulation Of Cellular Component Organization Negative Regulation Of Telomere Maintenance Positive Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Chromatin Assembly Or Disassembly DNA Metabolic Process Protein Localization To Chromosome Telomere Maintenance Via Telomere Lengthening Regulation Of Chromosome Organization Chromatin Modification Ras Protein Signal Transduction Organelle Organization Negative Regulation Of Biosynthetic Process Cellular Protein Localization Negative Regulation Of DNA Replication Chromatin Organization DNA Conformation Change Telomere Maintenance ATP-dependent Chromatin Remodeling Negative Regulation Of Protein ADP-ribosylation Positive Regulation Of DNA Strand Elongation Regulation Of Cellular Process DNA Duplex Unwinding DNA Geometric Change Histone Modification Positive Regulation Of Organelle Organization Negative Regulation Of Chromosome Organization Negative Regulation Of DNA Metabolic Process Regulation Of Protein ADP-ribosylation Regulation Of Vesicle Size Cellular Heat Acclimation Protein Localization Response To Abiotic Stimulus Receptor Internalization Involved In Canonical Wnt Signaling Pathway Regulation Of Endosome Size Telomere Formation Via Telomerase Negative Regulation Of Estrogen Receptor Binding Transcriptional Activation By Promoter-enhancer Looping Negative Regulation Of Cellular Metabolic Process Regulation Of DNA Replication Negative Regulation Of Protein Glycosylation Positive Regulation Of DNA Metabolic Process Histone H3-K9 Dimethylation Small GTPase Mediated Signal Transduction	Negative Regulation Of Telomere Maintenance Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomerase Activity Glycolytic Process Protection From Non-homologous End Joining At Telomere Carbohydrate Catabolic Process Negative Regulation Of DNA Replication Telomere Assembly Catabolic Process Negative Regulation Of DNA Metabolic Process Protein Localization To Chromosome, Telomeric Region Negative Regulation Of Catalytic Activity Positive Regulation Of Telomerase Activity Pyruvate Metabolic Process Telomere Maintenance Telomere Maintenance Via Telomerase Pathogenesis Generation Of Precursor Metabolites And Energy Glucose Metabolic Process Positive Regulation Of Single-stranded Telomeric DNA Binding Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Negative Regulation Of Chromosome Organization Small Molecule Metabolic Process Organic Acid Metabolic Process Regulation Of DNA Biosynthetic Process Regulation Of Catalytic Activity Carboxylic Acid Metabolic Process Age-dependent Telomere Shortening Telomeric Loop Formation Nervous System Development Regulation Of Signaling Positive Regulation Of DNA Biosynthetic Process Glycogen Metabolic Process RNA-dependent DNA Replication Nucleoside Metabolic Process Telomere Maintenance Via Telomere Shortening Regulation Of Signal Transduction Hexose Metabolic Process Cellular Process Regulation Of DNA Replication Monocarboxylic Acid Metabolic Process Cellular Carbohydrate Metabolic Process Response To Stimulus Protein Localization To Chromosome Organelle Organization Telomere Maintenance Via Telomere Lengthening Polysaccharide Metabolic Process
Tagcloud ?		adaptor alanine appl1 bar conditional diminishes elusive evoked fine glut4 gtpase homolog hyperglycemia likewise muscles myotubes partner potentiates rab serine skeletal stimulates substitution suppresses suppressive tbc1d1 threonine tune uptake	acd add broader clustered clustering convincingly correction cosegregated ends families fisher germline inactivating lod logarithm melanoma nonsense pot1 predispose probands q320x r364x shelterin tailed terf1 terf2 terf2ip yates
Tagcloud (Difference) ?		adaptor alanine appl1 bar conditional diminishes elusive evoked fine glut4 gtpase homolog hyperglycemia likewise muscles myotubes partner potentiates rab serine skeletal stimulates substitution suppresses suppressive tbc1d1 threonine tune uptake	acd add broader clustered clustering convincingly correction cosegregated ends families fisher germline inactivating lod logarithm melanoma nonsense pot1 predispose probands q320x r364x shelterin tailed terf1 terf2 terf2ip yates
Tagcloud (Intersection) ?