APPL2 and SUV39H2

Number of citations of the paper that reports this interaction (PMID 23455924)
3

Data Source:
BioGRID (two hybrid, two hybrid)

		APPL2	SUV39H2
Gene Name		adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2	suppressor of variegation 3-9 homolog 2 (Drosophila)
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Endosome Membrane NuRD Complex Early Endosome Membrane Extracellular Vesicular Exosome	Chromosome, Centromeric Region Chromatin Nucleoplasm Nuclear Heterochromatin
	Molecular Function	Protein Binding	Transcription Regulatory Region Sequence-specific DNA Binding Chromatin Binding Protein Binding Zinc Ion Binding Histone Methyltransferase Activity (H3-K9 Specific)
	Biological Process	Cell Cycle Signal Transduction Cell Proliferation	Negative Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Organization Chromatin Assembly Or Disassembly Chromatin Remodeling Transcription, DNA-templated Male Meiosis Cell Differentiation Histone H3-K9 Dimethylation Histone H3-K9 Trimethylation Negative Regulation Of Circadian Rhythm Negative Regulation Of Transcription, DNA-templated Rhythmic Process Cellular Response To Hypoxia
Pathways			Chromatin modifying enzymes Chromatin organization PKMTs methylate histone lysines
Drugs
Diseases
GWAS
Protein-Protein Interactions		11 interactors: APPL1 CRADD MTA2 POT1 RAB22A RAB5A RAB5C RBBP7 RUVBL2 SUV39H2 TINF2	39 interactors: AKAP9 APPL2 BLZF1 C8orf74 CBX5 CBX7 CCDC151 CCDC37 CDCA4 CEP70 CGGBP1 EWSR1 FAM20C GSTCD ID2 KCTD17 KLF3 KLHDC4 LCA5L LNX1 LRIF1 MCM3AP MRFAP1 MTF2 MYL12A NME4 PHF19 PNMA1 POLR3F RAB3IP RASSF1 SHC1 SMAD5 SNF8 UBE2V2 WIZ ZNF212 ZNF557 ZNF57
Entrez ID		55198	79723
HPRD ID		06945	07580
Ensembl ID		ENSG00000136044	ENSG00000152455
Uniprot IDs		Q8NEU8	Q9H5I1
PDB IDs		4H8S	2R3A
Enriched GO Terms of Interacting Partners?		Chromatin Remodeling Chromosome Organization Rab Protein Signal Transduction Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Assembly Regulation Of Cellular Component Organization Negative Regulation Of Telomere Maintenance Positive Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Chromatin Assembly Or Disassembly DNA Metabolic Process Protein Localization To Chromosome Telomere Maintenance Via Telomere Lengthening Regulation Of Chromosome Organization Chromatin Modification Ras Protein Signal Transduction Organelle Organization Negative Regulation Of Biosynthetic Process Cellular Protein Localization Negative Regulation Of DNA Replication Chromatin Organization DNA Conformation Change Telomere Maintenance ATP-dependent Chromatin Remodeling Negative Regulation Of Protein ADP-ribosylation Positive Regulation Of DNA Strand Elongation Regulation Of Cellular Process DNA Duplex Unwinding DNA Geometric Change Histone Modification Positive Regulation Of Organelle Organization Negative Regulation Of Chromosome Organization Negative Regulation Of DNA Metabolic Process Regulation Of Protein ADP-ribosylation Regulation Of Vesicle Size Cellular Heat Acclimation Protein Localization Response To Abiotic Stimulus Receptor Internalization Involved In Canonical Wnt Signaling Pathway Regulation Of Endosome Size Telomere Formation Via Telomerase Negative Regulation Of Estrogen Receptor Binding Transcriptional Activation By Promoter-enhancer Looping Negative Regulation Of Cellular Metabolic Process Regulation Of DNA Replication Negative Regulation Of Protein Glycosylation Positive Regulation Of DNA Metabolic Process Histone H3-K9 Dimethylation Small GTPase Mediated Signal Transduction	Regulation Of Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Cellular Process Positive Regulation Of Histone H3-K27 Methylation Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Histone H3-K27 Methylation Regulation Of RNA Metabolic Process Gene Expression Nucleobase-containing Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Osteoblast Differentiation Biosynthetic Process Regulation Of Epidermal Growth Factor-activated Receptor Activity Golgi To Plasma Membrane Transport Positive Regulation Of Histone Methylation Nitrogen Compound Metabolic Process Positive Regulation Of DNA Metabolic Process Osteoclast Maturation Regulation Of Histone Methylation Regulation Of Ossification Protein Targeting Positive Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription, DNA-templated Regulation Of Protein Tyrosine Kinase Activity Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of RNA Biosynthetic Process Establishment Of Protein Localization To Membrane Positive Regulation Of DNA Replication Positive Regulation Of Histone Modification Protein Targeting To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Positive Regulation Of Osteoblast Differentiation Myeloid Cell Differentiation Negative Regulation Of Gene Expression, Epigenetic Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Establishment Of Protein Localization To Plasma Membrane Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition
Tagcloud ?		adaptor alanine appl1 bar conditional diminishes elusive evoked fine glut4 gtpase homolog hyperglycemia likewise muscles myotubes partner potentiates rab serine skeletal stimulates substitution suppresses suppressive tbc1d1 threonine tune uptake	a7 circular dichroism dim g12 g13 g9a h3k9 h3k9me0 h3k9me1 h3k9me2 h3k9me3 introduce introduces k14 labrador n324k pkmts prefers processive r8 readout recognizes renders retrievers s10 t11 t6
Tagcloud (Difference) ?		adaptor alanine appl1 bar conditional diminishes elusive evoked fine glut4 gtpase homolog hyperglycemia likewise muscles myotubes partner potentiates rab serine skeletal stimulates substitution suppresses suppressive tbc1d1 threonine tune uptake	a7 circular dichroism dim g12 g13 g9a h3k9 h3k9me0 h3k9me1 h3k9me2 h3k9me3 introduce introduces k14 labrador n324k pkmts prefers processive r8 readout recognizes renders retrievers s10 t11 t6
Tagcloud (Intersection) ?