APPL2 and RUVBL2

Number of citations of the paper that reports this interaction (PMID 19433865)
12

Data Source:
BioGRID (pull down)

		APPL2	RUVBL2
Gene Name		adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2	RuvB-like AAA ATPase 2
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Endosome Membrane NuRD Complex Early Endosome Membrane Extracellular Vesicular Exosome	Swr1 Complex Intracellular Nucleus Nucleoplasm Nuclear Euchromatin Cytoplasm Membrane Nuclear Matrix Ribonucleoprotein Complex Ino80 Complex NuA4 Histone Acetyltransferase Complex Extracellular Vesicular Exosome MLL1 Complex
	Molecular Function	Protein Binding	RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding DNA Helicase Activity Damaged DNA Binding ATP-dependent DNA Helicase Activity Protein Binding ATP Binding ATPase Activity Chromatin DNA Binding Identical Protein Binding ATP-dependent 5'-3' DNA Helicase Activity Unfolded Protein Binding
	Biological Process	Cell Cycle Signal Transduction Cell Proliferation	DNA Repair DNA Recombination Chromatin Organization Chromatin Remodeling Transcription, DNA-templated Protein Folding DNA Duplex Unwinding Cellular Response To UV Positive Regulation Of Histone Acetylation Regulation Of Growth Histone H4 Acetylation Histone H2A Acetylation Positive Regulation Of Transcription From RNA Polymerase II Promoter Establishment Of Protein Localization To Chromatin Cellular Response To Estradiol Stimulus Transcriptional Activation By Promoter-enhancer Looping Negative Regulation Of Estrogen Receptor Binding
Pathways			Chromatin modifying enzymes Telomere Maintenance Chromosome Maintenance Chromatin organization Extension of Telomeres Telomere Extension By Telomerase HATs acetylate histones
Drugs
Diseases
GWAS
Protein-Protein Interactions		11 interactors: APPL1 CRADD MTA2 POT1 RAB22A RAB5A RAB5C RBBP7 RUVBL2 SUV39H2 TINF2	27 interactors: APP APPL1 APPL2 ATF2 BCL3 CCDC103 CDKN2A CTNNB1 DPCD EHMT2 EXOSC10 FBL FDFT1 HDAC1 HDAC4 LIG4 LNX1 MDM2 NDRG1 NUFIP1 PIH1D1 RUVBL1 STOM TAF9 TBP TERT YWHAQ
Entrez ID		55198	10856
HPRD ID		06945	16070
Ensembl ID		ENSG00000136044	ENSG00000183207
Uniprot IDs		Q8NEU8	B3KNL2 B3KQ59 Q9Y230
PDB IDs		4H8S	2CQA 2XSZ 3UK6
Enriched GO Terms of Interacting Partners?		Chromatin Remodeling Chromosome Organization Rab Protein Signal Transduction Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Assembly Regulation Of Cellular Component Organization Negative Regulation Of Telomere Maintenance Positive Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Chromatin Assembly Or Disassembly DNA Metabolic Process Protein Localization To Chromosome Telomere Maintenance Via Telomere Lengthening Regulation Of Chromosome Organization Chromatin Modification Ras Protein Signal Transduction Organelle Organization Negative Regulation Of Biosynthetic Process Cellular Protein Localization Negative Regulation Of DNA Replication Chromatin Organization DNA Conformation Change Telomere Maintenance ATP-dependent Chromatin Remodeling Negative Regulation Of Protein ADP-ribosylation Positive Regulation Of DNA Strand Elongation Regulation Of Cellular Process DNA Duplex Unwinding DNA Geometric Change Histone Modification Positive Regulation Of Organelle Organization Negative Regulation Of Chromosome Organization Negative Regulation Of DNA Metabolic Process Regulation Of Protein ADP-ribosylation Regulation Of Vesicle Size Cellular Heat Acclimation Protein Localization Response To Abiotic Stimulus Receptor Internalization Involved In Canonical Wnt Signaling Pathway Regulation Of Endosome Size Telomere Formation Via Telomerase Negative Regulation Of Estrogen Receptor Binding Transcriptional Activation By Promoter-enhancer Looping Negative Regulation Of Cellular Metabolic Process Regulation Of DNA Replication Negative Regulation Of Protein Glycosylation Positive Regulation Of DNA Metabolic Process Histone H3-K9 Dimethylation Small GTPase Mediated Signal Transduction	Chromatin Modification Positive Regulation Of Gene Expression Chromatin Organization Chromosome Organization Negative Regulation Of Cellular Metabolic Process Regulation Of Gene Expression, Epigenetic Histone Modification Regulation Of Transcription From RNA Polymerase II Promoter RNA Metabolic Process Cellular Component Assembly Peptidyl-lysine Modification Apoptotic Process Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Programmed Cell Death Positive Regulation Of Transcription From RNA Polymerase II Promoter Cell Cycle Cell Death Death Regulation Of Protein Sumoylation Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Apoptotic Process Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Death Box C/D SnoRNP Assembly Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Biosynthetic Process Histone H3-K9 Modification Developmental Process Posttranscriptional Regulation Of Gene Expression Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Signal Transduction By P53 Class Mediator Sexual Reproduction Ribonucleoprotein Complex Biogenesis Gene Expression Cellular Response To DNA Damage Stimulus Negative Regulation Of Protein Metabolic Process Negative Regulation Of Apoptotic Process Fungiform Papilla Formation Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Programmed Cell Death Chromatin Remodeling
Tagcloud ?		adaptor alanine appl1 bar conditional diminishes elusive evoked fine glut4 gtpase homolog hyperglycemia likewise muscles myotubes partner potentiates rab serine skeletal stimulates substitution suppresses suppressive tbc1d1 threonine tune uptake	ac accessible architecture attenuates baz1b clarify cytoprotective foci gammah2ax h2ax h3k56 h3k9 hubs integrated ints3 irradiation isoform mark matrix mount prevents proteomic respond runx runx2 scaffolding subnuclear supported
Tagcloud (Difference) ?		adaptor alanine appl1 bar conditional diminishes elusive evoked fine glut4 gtpase homolog hyperglycemia likewise muscles myotubes partner potentiates rab serine skeletal stimulates substitution suppresses suppressive tbc1d1 threonine tune uptake	ac accessible architecture attenuates baz1b clarify cytoprotective foci gammah2ax h2ax h3k56 h3k9 hubs integrated ints3 irradiation isoform mark matrix mount prevents proteomic respond runx runx2 scaffolding subnuclear supported
Tagcloud (Intersection) ?