APPL2 and KMT2C

Number of citations of the paper that reports this interaction (PubMedID 25814554)
62

Data Source:
BioGRID (two hybrid)

		APPL2	KMT2C
Description		adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2	lysine methyltransferase 2C
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GO Annotations	Cellular Component	Ruffle Nucleus Cytoplasm Endosome Plasma Membrane Endosome Membrane Membrane Cytoplasmic Vesicle Membrane Phagocytic Vesicle Membrane Cytoplasmic Vesicle Early Endosome Membrane Vesicle Early Phagosome Ruffle Membrane Early Phagosome Membrane Cell Projection Macropinosome Phagocytic Vesicle Extracellular Exosome Bounding Membrane Of Organelle	Nucleus Nucleoplasm Cytosol Histone Methyltransferase Complex MLL3/4 Complex
	Molecular Function	Phosphatidylserine Binding Protein Binding Phosphatidylinositol Binding Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding	DNA Binding Transcription Coactivator Activity RNA Binding Protein Binding Methyltransferase Activity Zinc Ion Binding Transferase Activity Acyltransferase Activity Histone Methyltransferase Activity Histone H3K4 Methyltransferase Activity Metal Ion Binding Histone H3K4 Monomethyltransferase Activity Histone H3K4 Trimethyltransferase Activity
	Biological Process	Diet Induced Thermogenesis Protein Import Into Nucleus Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Cold Acclimation Regulation Of Fibroblast Migration Signaling Adiponectin-activated Signaling Pathway Regulation Of Toll-like Receptor 4 Signaling Pathway Cellular Response To Hepatocyte Growth Factor Stimulus Homeostatic Process Glucose Homeostasis Regulation Of Innate Immune Response Negative Regulation Of Fatty Acid Oxidation Negative Regulation Of D-glucose Import Negative Regulation Of Neurogenesis Protein Homotetramerization Positive Regulation Of Phagocytosis, Engulfment Positive Regulation Of Cold-induced Thermogenesis Negative Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of Cellular Response To Insulin Stimulus Positive Regulation Of Macropinocytosis Positive Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Neural Precursor Cell Proliferation	Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription Methylation Positive Regulation Of Transcription By RNA Polymerase II
Pathways			PKMTs methylate histone lysines Activation of anterior HOX genes in hindbrain development during early embryogenesis RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Formation of WDR5-containing histone-modifying complexes Epigenetic regulation of gene expression by MLL3 and MLL4 complexes MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Regulation of PD-L1(CD274) transcription
Drugs
Diseases
GWAS		Mosquito bite size ( 28199695)
Interacting Genes		31 interacting genes: APPL1 ATF3 CNMD CRADD CRBN CRLF3 CRYAA DOK3 EPM2AIP1 HUNK KIFC3 KMT2C LDHAL6B LGALS9C LINC02875 LIX1 MLST8 MTA2 PINK1 POT1 PRR35 RAB22A RAB5A RAB5C RAI2 RBBP7 RBP7 RUVBL2 SUV39H2 TINF2 TSC1	14 interacting genes: APPL2 DPY30 H2AC4 H2BC3 H3-4 H3C1 H3C14 H4C1 JUN MAPK14 MTNR1B RNF10 SMARCB1 TSC22D1
Entrez ID		55198	58508
HPRD ID		06945	06016
Ensembl ID		ENSG00000136044	ENSG00000055609
Uniprot IDs		Q8NEU8	Q8NEZ4
PDB IDs		4H8S 5C5B	2YSM 2YUK 3UVL 4ERY 5F59 5F6K 6KIW 6MLC 7W6L
Enriched GO Terms of Interacting Partners?		Telomere Assembly Regulation Of Cellular Component Organization Response To Oxygen Levels Response To Decreased Oxygen Levels Plasma Membrane To Endosome Transport GDP Binding Early Phagosome NuRD Complex Chromosome, Telomeric Region Cellular Response To Decreased Oxygen Levels Cellular Response To Oxygen Levels Positive Regulation Of Telomere Maintenance Regulation Of DNA Strand Elongation Nuclear Telomere Cap Complex Shelterin Complex Telomere Capping Protein Kinase B Binding TORC2 Signaling Protein Binding Regulation Of Vesicle Size Phagocytic Vesicle TOR Signaling Negative Regulation Of Telomere Maintenance Via Telomerase Regulation Of Cell Fate Specification Positive Regulation Of Cellular Component Organization Telomere Maintenance Protein Stabilization Ruffle Negative Regulation Of Autophagy Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Regulation Of Cellular Component Size Telomeric DNA Binding Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Endomembrane System Negative Regulation Of DNA Biosynthetic Process Positive Regulation Of TRAIL-activated Apoptotic Signaling Pathway Memory T Cell Differentiation Protein Folding Chaperone Complex Epigenetic Programming Of Gene Expression Telomere Organization Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Negative Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Generation Of Precursor Metabolites And Energy Histone Methyltransferase Activity Positive Regulation Of Biosynthetic Process Response To Hypoxia Negative Regulation Of Macroautophagy	Structural Constituent Of Chromatin Nucleosome Nucleosome Organization Protein-DNA Complex Assembly Chromatin Remodeling Nucleosome Assembly Chromatin Organization Protein Heterodimerization Activity Protein-containing Complex Assembly Protein-containing Complex Organization DNA Binding Chromosome Negative Regulation Of Cell Population Proliferation Nucleus Regulation Of Cell Development Epigenetic Regulation Of Gene Expression Regulation Of Cell Differentiation Host-mediated Activation Of Viral Transcription CENP-A Containing Nucleosome Protein Localization To CENP-A Containing Chromatin Regulation Of Cell Population Proliferation Response To Muscle Stretch Cellular Component Assembly Host-mediated Perturbation Of Viral Transcription Nuclear Chromosome Regulation Of Hemopoiesis Chromosome, Telomeric Region Host-mediated Activation Of Viral Process Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Protein Localization To Chromosome, Centromeric Region Regulation Of Multicellular Organismal Development Positive Regulation Of Myoblast Differentiation Regulation Of Gene Expression Transcription Initiation-coupled Chromatin Remodeling Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Protein Localization To Chromatin Positive Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Multicellular Organismal Process Positive Regulation Of Gene Expression, Epigenetic Regulation Of Macromolecule Biosynthetic Process Regulation Of D-glucose Import Nucleoplasm Negative Regulation Of Cell Development Regulation Of Developmental Process Leading Edge Cell Differentiation Positive Regulation Of Macropinocytosis Regulation Of D-glucose Transmembrane Transport Regulation Of Myoblast Differentiation Host-mediated Perturbation Of Viral Process Negative Regulation Of Cell Differentiation
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