APPL2 and PRR35

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		APPL2	PRR35
Description		adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2	proline rich 35
Image			No pdb structure
GO Annotations	Cellular Component	Ruffle Nucleus Cytoplasm Endosome Plasma Membrane Endosome Membrane Membrane Cytoplasmic Vesicle Membrane Phagocytic Vesicle Membrane Cytoplasmic Vesicle Early Endosome Membrane Vesicle Early Phagosome Ruffle Membrane Early Phagosome Membrane Cell Projection Macropinosome Phagocytic Vesicle Extracellular Exosome Bounding Membrane Of Organelle
	Molecular Function	Phosphatidylserine Binding Protein Binding Phosphatidylinositol Binding Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding	Protein Binding
	Biological Process	Diet Induced Thermogenesis Protein Import Into Nucleus Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Cold Acclimation Regulation Of Fibroblast Migration Signaling Adiponectin-activated Signaling Pathway Regulation Of Toll-like Receptor 4 Signaling Pathway Cellular Response To Hepatocyte Growth Factor Stimulus Homeostatic Process Glucose Homeostasis Regulation Of Innate Immune Response Negative Regulation Of Fatty Acid Oxidation Negative Regulation Of D-glucose Import Negative Regulation Of Neurogenesis Protein Homotetramerization Positive Regulation Of Phagocytosis, Engulfment Positive Regulation Of Cold-induced Thermogenesis Negative Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of Cellular Response To Insulin Stimulus Positive Regulation Of Macropinocytosis Positive Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Neural Precursor Cell Proliferation
Pathways
Drugs
Diseases
GWAS		Mosquito bite size ( 28199695)	L1-L4 bone mineral density x serum urate levels interaction ( 34046847)
Interacting Genes		31 interacting genes: APPL1 ATF3 CNMD CRADD CRBN CRLF3 CRYAA DOK3 EPM2AIP1 HUNK KIFC3 KMT2C LDHAL6B LGALS9C LINC02875 LIX1 MLST8 MTA2 PINK1 POT1 PRR35 RAB22A RAB5A RAB5C RAI2 RBBP7 RBP7 RUVBL2 SUV39H2 TINF2 TSC1	80 interacting genes: ABHD11 ACTMAP ACY1 APPL2 ARMC5 ASB15 BEGAIN BIRC7 BPIFA1 CARD10 CCDC136 CFAP68 CNOT2 CRX CYSRT1 EXOC8 FAM168B FHL3 FRYL GIGYF1 GRAP2 HOMER3 HOOK2 HPCA HSPB2 HSPB2-C11orf52 INSC INTS11 JUP KLHL26 KRT31 KRT34 KRT35 KRTAP10-7 KRTAP12-1 KRTAP26-1 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP8-1 LASP1 LONRF1 LZTS2 MAGED1 MCCD1 MKRN3 MSS51 MTUS2 N4BP3 NBPF19 NOTCH2NLA OIP5 OXER1 PFDN5 PLAGL2 PPIL1 PPP1R13B PRR20A PRR20B PRR20C PRR20D PRR20E PSTPIP1 RBPMS RNF144B RUSC1 SMUG1 SPAG8 TBX19 TLE5 TRIM27 TRIM54 TRIM73 TTC19 TTLL12 UBASH3B UBXN11 USP54 ZMYND12 ZNF655
Entrez ID		55198	146325
HPRD ID		06945	10046
Ensembl ID		ENSG00000136044	ENSG00000161992
Uniprot IDs		Q8NEU8	P0CG20
PDB IDs		4H8S 5C5B
Enriched GO Terms of Interacting Partners?		Telomere Assembly Regulation Of Cellular Component Organization Response To Oxygen Levels Response To Decreased Oxygen Levels Plasma Membrane To Endosome Transport GDP Binding Early Phagosome NuRD Complex Chromosome, Telomeric Region Cellular Response To Decreased Oxygen Levels Cellular Response To Oxygen Levels Positive Regulation Of Telomere Maintenance Regulation Of DNA Strand Elongation Nuclear Telomere Cap Complex Shelterin Complex Telomere Capping Protein Kinase B Binding TORC2 Signaling Protein Binding Regulation Of Vesicle Size Phagocytic Vesicle TOR Signaling Negative Regulation Of Telomere Maintenance Via Telomerase Regulation Of Cell Fate Specification Positive Regulation Of Cellular Component Organization Telomere Maintenance Protein Stabilization Ruffle Negative Regulation Of Autophagy Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Regulation Of Cellular Component Size Telomeric DNA Binding Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Endomembrane System Negative Regulation Of DNA Biosynthetic Process Positive Regulation Of TRAIL-activated Apoptotic Signaling Pathway Memory T Cell Differentiation Protein Folding Chaperone Complex Epigenetic Programming Of Gene Expression Telomere Organization Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Negative Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Generation Of Precursor Metabolites And Energy Histone Methyltransferase Activity Positive Regulation Of Biosynthetic Process Response To Hypoxia Negative Regulation Of Macroautophagy	Intermediate Filament Keratin Filament
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